![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: CLCN6 |
Gene summary for CLCN6 |
![]() |
Gene information | Species | Human | Gene symbol | CLCN6 | Gene ID | 1185 |
Gene name | chloride voltage-gated channel 6 | |
Gene Alias | CLC-6 | |
Cytomap | 1p36.22 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | P51797 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1185 | CLCN6 | LZE20T | Human | Esophagus | ESCC | 4.98e-02 | 9.16e-02 | 0.0662 |
1185 | CLCN6 | LZE24T | Human | Esophagus | ESCC | 5.13e-03 | 1.12e-01 | 0.0596 |
1185 | CLCN6 | P2T-E | Human | Esophagus | ESCC | 1.13e-04 | 1.29e-01 | 0.1177 |
1185 | CLCN6 | P4T-E | Human | Esophagus | ESCC | 2.20e-02 | 9.24e-02 | 0.1323 |
1185 | CLCN6 | P5T-E | Human | Esophagus | ESCC | 1.56e-09 | 7.07e-02 | 0.1327 |
1185 | CLCN6 | P8T-E | Human | Esophagus | ESCC | 5.69e-19 | 1.30e-01 | 0.0889 |
1185 | CLCN6 | P10T-E | Human | Esophagus | ESCC | 2.90e-10 | 2.28e-01 | 0.116 |
1185 | CLCN6 | P12T-E | Human | Esophagus | ESCC | 2.96e-10 | 1.55e-01 | 0.1122 |
1185 | CLCN6 | P15T-E | Human | Esophagus | ESCC | 5.83e-12 | 2.36e-01 | 0.1149 |
1185 | CLCN6 | P16T-E | Human | Esophagus | ESCC | 5.97e-07 | 8.33e-02 | 0.1153 |
1185 | CLCN6 | P19T-E | Human | Esophagus | ESCC | 6.53e-04 | 2.66e-01 | 0.1662 |
1185 | CLCN6 | P20T-E | Human | Esophagus | ESCC | 8.24e-04 | 9.82e-02 | 0.1124 |
1185 | CLCN6 | P21T-E | Human | Esophagus | ESCC | 5.69e-07 | 1.98e-01 | 0.1617 |
1185 | CLCN6 | P22T-E | Human | Esophagus | ESCC | 5.02e-09 | 8.18e-02 | 0.1236 |
1185 | CLCN6 | P23T-E | Human | Esophagus | ESCC | 1.83e-07 | 1.76e-01 | 0.108 |
1185 | CLCN6 | P26T-E | Human | Esophagus | ESCC | 4.73e-06 | 9.76e-02 | 0.1276 |
1185 | CLCN6 | P27T-E | Human | Esophagus | ESCC | 1.36e-16 | 1.32e-01 | 0.1055 |
1185 | CLCN6 | P28T-E | Human | Esophagus | ESCC | 4.73e-03 | 1.08e-01 | 0.1149 |
1185 | CLCN6 | P30T-E | Human | Esophagus | ESCC | 7.79e-07 | 2.00e-01 | 0.137 |
1185 | CLCN6 | P31T-E | Human | Esophagus | ESCC | 1.36e-08 | 1.67e-01 | 0.1251 |
Page: 1 2 3 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003253520 | Esophagus | ESCC | regulation of cellular component size | 227/8552 | 383/18723 | 4.77e-08 | 8.60e-07 | 227 |
GO:00083619 | Esophagus | ESCC | regulation of cell size | 107/8552 | 181/18723 | 1.81e-04 | 1.16e-03 | 107 |
GO:000961216 | Esophagus | ESCC | response to mechanical stimulus | 124/8552 | 216/18723 | 3.30e-04 | 1.94e-03 | 124 |
GO:003253522 | Liver | HCC | regulation of cellular component size | 217/7958 | 383/18723 | 1.28e-08 | 3.14e-07 | 217 |
GO:00096124 | Liver | HCC | response to mechanical stimulus | 113/7958 | 216/18723 | 2.20e-03 | 1.10e-02 | 113 |
GO:00083614 | Liver | HCC | regulation of cell size | 95/7958 | 181/18723 | 4.15e-03 | 1.81e-02 | 95 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CLCN6 | SNV | Missense_Mutation | rs763754640 | c.2486N>T | p.Thr829Met | p.T829M | P51797 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CLCN6 | SNV | Missense_Mutation | rs556741884 | c.1604G>A | p.Arg535His | p.R535H | P51797 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CLCN6 | SNV | Missense_Mutation | novel | c.2162N>G | p.Tyr721Cys | p.Y721C | P51797 | protein_coding | tolerated(0.11) | benign(0.338) | TCGA-DD-AACI-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CLCN6 | SNV | Missense_Mutation | novel | c.698G>T | p.Arg233Leu | p.R233L | P51797 | protein_coding | deleterious(0) | possibly_damaging(0.803) | TCGA-DD-AAVQ-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
CLCN6 | SNV | Missense_Mutation | c.1973A>T | p.Lys658Met | p.K658M | P51797 | protein_coding | tolerated(0.17) | benign(0.015) | TCGA-G3-A3CK-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CLCN6 | SNV | Missense_Mutation | c.112N>A | p.Glu38Lys | p.E38K | P51797 | protein_coding | tolerated(0.14) | benign(0.135) | TCGA-05-5428-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR | |
CLCN6 | SNV | Missense_Mutation | c.502N>T | p.Gly168Cys | p.G168C | P51797 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-50-6590-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | paclitaxel | CR | |
CLCN6 | SNV | Missense_Mutation | rs149322151 | c.2335G>A | p.Glu779Lys | p.E779K | P51797 | protein_coding | tolerated(0.09) | benign(0.118) | TCGA-55-A4DG-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CLCN6 | SNV | Missense_Mutation | rs769924243 | c.2393G>T | p.Arg798Leu | p.R798L | P51797 | protein_coding | tolerated(0.07) | possibly_damaging(0.605) | TCGA-MN-A4N4-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CLCN6 | SNV | Missense_Mutation | novel | c.2255N>A | p.Thr752Asn | p.T752N | P51797 | protein_coding | tolerated(0.36) | benign(0) | TCGA-NJ-A4YQ-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1185 | CLCN6 | ION CHANNEL, DRUGGABLE GENOME | blocker | 178100996 | ||
1185 | CLCN6 | ION CHANNEL, DRUGGABLE GENOME | antipsychotics | 17976958 |
Page: 1 |