Tissue | Expression Dynamics | Abbreviation |
Breast | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Breast/CDK12_pca_on_diff_genes.png) | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/CDK12_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/CDK12_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/CDK12_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/CDK12_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/CDK12_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/CDK12_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000838014 | Breast | IDC | RNA splicing | 73/1434 | 434/18723 | 1.27e-10 | 1.57e-08 | 73 |
GO:004348414 | Breast | IDC | regulation of RNA splicing | 36/1434 | 148/18723 | 3.32e-10 | 3.77e-08 | 36 |
GO:000838024 | Breast | DCIS | RNA splicing | 73/1390 | 434/18723 | 3.05e-11 | 5.08e-09 | 73 |
GO:004348424 | Breast | DCIS | regulation of RNA splicing | 36/1390 | 148/18723 | 1.40e-10 | 1.69e-08 | 36 |
GO:000838026 | Esophagus | HGIN | RNA splicing | 160/2587 | 434/18723 | 3.74e-34 | 1.12e-30 | 160 |
GO:004348427 | Esophagus | HGIN | regulation of RNA splicing | 59/2587 | 148/18723 | 3.61e-15 | 7.22e-13 | 59 |
GO:00063687 | Esophagus | HGIN | transcription elongation from RNA polymerase II promoter | 24/2587 | 69/18723 | 8.93e-06 | 2.64e-04 | 24 |
GO:20007375 | Esophagus | HGIN | negative regulation of stem cell differentiation | 12/2587 | 23/18723 | 1.45e-05 | 4.02e-04 | 12 |
GO:20007365 | Esophagus | HGIN | regulation of stem cell differentiation | 20/2587 | 58/18723 | 5.65e-05 | 1.33e-03 | 20 |
GO:00063548 | Esophagus | HGIN | DNA-templated transcription, elongation | 27/2587 | 91/18723 | 6.62e-05 | 1.52e-03 | 27 |
GO:00342435 | Esophagus | HGIN | regulation of transcription elongation from RNA polymerase II promoter | 13/2587 | 32/18723 | 1.72e-04 | 3.32e-03 | 13 |
GO:00327866 | Esophagus | HGIN | positive regulation of DNA-templated transcription, elongation | 11/2587 | 27/18723 | 5.28e-04 | 7.56e-03 | 11 |
GO:00329685 | Esophagus | HGIN | positive regulation of transcription elongation from RNA polymerase II promoter | 7/2587 | 13/18723 | 7.61e-04 | 1.00e-02 | 7 |
GO:00327844 | Esophagus | HGIN | regulation of DNA-templated transcription, elongation | 16/2587 | 53/18723 | 1.58e-03 | 1.79e-02 | 16 |
GO:00708162 | Esophagus | HGIN | phosphorylation of RNA polymerase II C-terminal domain | 6/2587 | 12/18723 | 3.03e-03 | 2.88e-02 | 6 |
GO:0008380111 | Esophagus | ESCC | RNA splicing | 336/8552 | 434/18723 | 1.74e-42 | 3.67e-39 | 336 |
GO:0043484111 | Esophagus | ESCC | regulation of RNA splicing | 116/8552 | 148/18723 | 3.18e-16 | 2.38e-14 | 116 |
GO:000635414 | Esophagus | ESCC | DNA-templated transcription, elongation | 76/8552 | 91/18723 | 8.35e-14 | 4.11e-12 | 76 |
GO:007190016 | Esophagus | ESCC | regulation of protein serine/threonine kinase activity | 227/8552 | 359/18723 | 1.12e-11 | 4.10e-10 | 227 |
GO:000636814 | Esophagus | ESCC | transcription elongation from RNA polymerase II promoter | 56/8552 | 69/18723 | 1.40e-09 | 3.30e-08 | 56 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CDK12 | deletion | Frame_Shift_Del | | c.3805delN | p.Gly1271AspfsTer23 | p.G1271Dfs*23 | Q9NYV4 | protein_coding | | | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CDK12 | SNV | Missense_Mutation | novel | c.2165N>A | p.Arg722His | p.R722H | Q9NYV4 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CDK12 | SNV | Missense_Mutation | novel | c.2612N>A | p.Gly871Glu | p.G871E | Q9NYV4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CDK12 | SNV | Missense_Mutation | novel | c.2763N>A | p.Ser921Arg | p.S921R | Q9NYV4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CDK12 | SNV | Missense_Mutation | rs267604832 | c.2782N>A | p.Glu928Lys | p.E928K | Q9NYV4 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CDK12 | SNV | Missense_Mutation | novel | c.3310N>A | p.Leu1104Ile | p.L1104I | Q9NYV4 | protein_coding | tolerated(0.09) | possibly_damaging(0.836) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CDK12 | SNV | Missense_Mutation | novel | c.3750N>T | p.Glu1250Asp | p.E1250D | Q9NYV4 | protein_coding | tolerated_low_confidence(0.12) | benign(0.003) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CDK12 | SNV | Missense_Mutation | novel | c.1671N>G | p.Ile557Met | p.I557M | Q9NYV4 | protein_coding | tolerated_low_confidence(0.1) | benign(0.009) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CDK12 | SNV | Missense_Mutation | novel | c.2165N>A | p.Arg722His | p.R722H | Q9NYV4 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CDK12 | SNV | Missense_Mutation | | c.623N>C | p.Lys208Thr | p.K208T | Q9NYV4 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.968) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
51755 | CDK12 | KINASE, CLINICALLY ACTIONABLE, DRUGGABLE GENOME, ENZYME, TUMOR SUPPRESSOR, SERINE THREONINE KINASE | inhibitor | 375973251 | | |
51755 | CDK12 | KINASE, CLINICALLY ACTIONABLE, DRUGGABLE GENOME, ENZYME, TUMOR SUPPRESSOR, SERINE THREONINE KINASE | | Cemiplimab | CEMIPLIMAB | |
51755 | CDK12 | KINASE, CLINICALLY ACTIONABLE, DRUGGABLE GENOME, ENZYME, TUMOR SUPPRESSOR, SERINE THREONINE KINASE | inhibitor | CHEMBL445813 | AT-7519 | |
51755 | CDK12 | KINASE, CLINICALLY ACTIONABLE, DRUGGABLE GENOME, ENZYME, TUMOR SUPPRESSOR, SERINE THREONINE KINASE | | Nivolumab | NIVOLUMAB | |
51755 | CDK12 | KINASE, CLINICALLY ACTIONABLE, DRUGGABLE GENOME, ENZYME, TUMOR SUPPRESSOR, SERINE THREONINE KINASE | | OLAPARIB | OLAPARIB | 24240700 |
51755 | CDK12 | KINASE, CLINICALLY ACTIONABLE, DRUGGABLE GENOME, ENZYME, TUMOR SUPPRESSOR, SERINE THREONINE KINASE | | Pembrolizumab | PEMBROLIZUMAB | |
51755 | CDK12 | KINASE, CLINICALLY ACTIONABLE, DRUGGABLE GENOME, ENZYME, TUMOR SUPPRESSOR, SERINE THREONINE KINASE | inhibitor | CHEMBL3544942 | RONICICLIB | |
51755 | CDK12 | KINASE, CLINICALLY ACTIONABLE, DRUGGABLE GENOME, ENZYME, TUMOR SUPPRESSOR, SERINE THREONINE KINASE | inhibitor | CHEMBL488436 | AZD-5438 | |
51755 | CDK12 | KINASE, CLINICALLY ACTIONABLE, DRUGGABLE GENOME, ENZYME, TUMOR SUPPRESSOR, SERINE THREONINE KINASE | inhibitor | CHEMBL1230607 | PHA-793887 | |