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Gene: CDH18 |
Gene summary for CDH18 |
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Gene information | Species | Human | Gene symbol | CDH18 | Gene ID | 1016 |
Gene name | cadherin 18 | |
Gene Alias | CDH14 | |
Cytomap | 5p14.3 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q13634 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1016 | CDH18 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.07e-06 | 1.87e-01 | -0.1464 |
1016 | CDH18 | HTA11_866_2000001011 | Human | Colorectum | AD | 5.45e-03 | 1.04e-01 | -0.1001 |
1016 | CDH18 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.77e-03 | 1.93e-01 | -0.059 |
1016 | CDH18 | HTA11_9408_2000001011 | Human | Colorectum | AD | 9.43e-18 | 1.03e+00 | 0.0451 |
1016 | CDH18 | HTA11_6801_2000001011 | Human | Colorectum | SER | 3.73e-10 | 6.54e-01 | 0.0171 |
1016 | CDH18 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 7.46e-19 | 5.25e-01 | 0.3859 |
1016 | CDH18 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 5.90e-18 | 9.18e-01 | 0.2585 |
1016 | CDH18 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.74e-94 | 1.97e+00 | 0.3005 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0045216 | Colorectum | AD | cell-cell junction organization | 80/3918 | 200/18723 | 5.57e-10 | 4.58e-08 | 80 |
GO:0034329 | Colorectum | AD | cell junction assembly | 136/3918 | 420/18723 | 2.02e-08 | 1.15e-06 | 136 |
GO:0007043 | Colorectum | AD | cell-cell junction assembly | 57/3918 | 146/18723 | 4.18e-07 | 1.61e-05 | 57 |
GO:0034332 | Colorectum | AD | adherens junction organization | 20/3918 | 49/18723 | 1.23e-03 | 1.09e-02 | 20 |
GO:00452161 | Colorectum | SER | cell-cell junction organization | 63/2897 | 200/18723 | 9.15e-09 | 7.80e-07 | 63 |
GO:00070431 | Colorectum | SER | cell-cell junction assembly | 45/2897 | 146/18723 | 2.23e-06 | 9.31e-05 | 45 |
GO:00343291 | Colorectum | SER | cell junction assembly | 100/2897 | 420/18723 | 4.23e-06 | 1.61e-04 | 100 |
GO:00452162 | Colorectum | MSS | cell-cell junction organization | 69/3467 | 200/18723 | 5.07e-08 | 2.70e-06 | 69 |
GO:00343292 | Colorectum | MSS | cell junction assembly | 120/3467 | 420/18723 | 2.51e-07 | 1.07e-05 | 120 |
GO:00070432 | Colorectum | MSS | cell-cell junction assembly | 50/3467 | 146/18723 | 4.24e-06 | 1.21e-04 | 50 |
GO:00343321 | Colorectum | MSS | adherens junction organization | 18/3467 | 49/18723 | 2.03e-03 | 1.74e-02 | 18 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CDH18 | SNV | Missense_Mutation | rs764611303 | c.1589N>C | p.Arg530Pro | p.R530P | Q13634 | protein_coding | deleterious(0.02) | benign(0.003) | TCGA-AX-A0IS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
CDH18 | SNV | Missense_Mutation | novel | c.1587N>C | p.Glu529Asp | p.E529D | Q13634 | protein_coding | deleterious(0.02) | benign(0.005) | TCGA-AX-A0IS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
CDH18 | SNV | Missense_Mutation | c.2140N>A | p.Glu714Lys | p.E714K | Q13634 | protein_coding | tolerated(0.11) | benign(0.403) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CDH18 | SNV | Missense_Mutation | rs565236156 | c.1913N>A | p.Arg638His | p.R638H | Q13634 | protein_coding | deleterious(0.01) | probably_damaging(0.969) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CDH18 | SNV | Missense_Mutation | rs372726350 | c.1750C>A | p.Leu584Ile | p.L584I | Q13634 | protein_coding | deleterious(0.01) | probably_damaging(0.986) | TCGA-AX-A1C5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | SD |
CDH18 | SNV | Missense_Mutation | rs565236156 | c.1913N>A | p.Arg638His | p.R638H | Q13634 | protein_coding | deleterious(0.01) | probably_damaging(0.969) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
CDH18 | SNV | Missense_Mutation | c.581N>T | p.Ser194Ile | p.S194I | Q13634 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD | |
CDH18 | SNV | Missense_Mutation | novel | c.1924G>A | p.Glu642Lys | p.E642K | Q13634 | protein_coding | tolerated(0.12) | benign(0.135) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
CDH18 | SNV | Missense_Mutation | rs765244838 | c.1912C>T | p.Arg638Cys | p.R638C | Q13634 | protein_coding | deleterious(0.01) | probably_damaging(0.969) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CDH18 | SNV | Missense_Mutation | novel | c.1325C>A | p.Thr442Asn | p.T442N | Q13634 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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