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Gene: CCDC170 |
Gene summary for CCDC170 |
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Gene information | Species | Human | Gene symbol | CCDC170 | Gene ID | 80129 |
Gene name | coiled-coil domain containing 170 | |
Gene Alias | C6orf97 | |
Cytomap | 6q25.1 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q8IYT3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80129 | CCDC170 | HCC2_Meng | Human | Liver | HCC | 2.39e-03 | 3.67e-02 | 0.0107 |
80129 | CCDC170 | HCC1 | Human | Liver | HCC | 6.31e-22 | 4.37e+00 | 0.5336 |
80129 | CCDC170 | HCC2 | Human | Liver | HCC | 3.91e-14 | 1.41e+00 | 0.5341 |
80129 | CCDC170 | HCC5 | Human | Liver | HCC | 3.79e-21 | 2.82e+00 | 0.4932 |
80129 | CCDC170 | S014 | Human | Liver | HCC | 2.09e-06 | 2.30e-01 | 0.2254 |
80129 | CCDC170 | S015 | Human | Liver | HCC | 2.71e-07 | 2.59e-01 | 0.2375 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CCDC170 | insertion | Frame_Shift_Ins | novel | c.2145_2146insAGCAGGAGAAGAGGTATGGCTTTTGAGGCAGGGCCAA | p.Ter716SerfsTer39 | p.*716Sfs*39 | Q8IYT3 | protein_coding | TCGA-D1-A102-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
CCDC170 | SNV | Missense_Mutation | novel | c.1874N>C | p.Met625Thr | p.M625T | Q8IYT3 | protein_coding | tolerated(0.06) | benign(0.003) | TCGA-XR-A8TF-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CCDC170 | SNV | Missense_Mutation | c.1085G>C | p.Arg362Thr | p.R362T | Q8IYT3 | protein_coding | deleterious(0.03) | benign(0.158) | TCGA-44-7667-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CCDC170 | SNV | Missense_Mutation | c.2119N>A | p.Pro707Thr | p.P707T | Q8IYT3 | protein_coding | tolerated(0.81) | benign(0.001) | TCGA-44-A4SS-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CCDC170 | SNV | Missense_Mutation | c.1969N>T | p.Val657Leu | p.V657L | Q8IYT3 | protein_coding | deleterious(0.01) | benign(0.025) | TCGA-53-7624-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | PD | |
CCDC170 | SNV | Missense_Mutation | c.888N>A | p.Ser296Arg | p.S296R | Q8IYT3 | protein_coding | tolerated(0.33) | benign(0.019) | TCGA-55-1592-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
CCDC170 | SNV | Missense_Mutation | c.1804N>C | p.Met602Leu | p.M602L | Q8IYT3 | protein_coding | tolerated(0.54) | benign(0.001) | TCGA-55-A491-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CCDC170 | SNV | Missense_Mutation | novel | c.1219N>G | p.Gln407Glu | p.Q407E | Q8IYT3 | protein_coding | deleterious(0.05) | benign(0.01) | TCGA-78-7539-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
CCDC170 | SNV | Missense_Mutation | novel | c.1399C>A | p.Gln467Lys | p.Q467K | Q8IYT3 | protein_coding | tolerated(0.06) | probably_damaging(0.999) | TCGA-78-8662-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
CCDC170 | SNV | Missense_Mutation | novel | c.1806G>T | p.Met602Ile | p.M602I | Q8IYT3 | protein_coding | tolerated(0.37) | benign(0.003) | TCGA-86-7711-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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