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Gene: CATSPERB |
Gene summary for CATSPERB |
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Gene information | Species | Human | Gene symbol | CATSPERB | Gene ID | 79820 |
Gene name | cation channel sperm associated auxiliary subunit beta | |
Gene Alias | C14orf161 | |
Cytomap | 14q32.12 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | B3KWW9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79820 | CATSPERB | RNA-P17T-P17T-2 | Human | Lung | IAC | 4.96e-05 | 6.66e-01 | 0.3371 |
79820 | CATSPERB | RNA-P17T-P17T-4 | Human | Lung | IAC | 1.83e-05 | 6.06e-01 | 0.343 |
79820 | CATSPERB | RNA-P17T-P17T-6 | Human | Lung | IAC | 1.04e-03 | 6.25e-01 | 0.3385 |
79820 | CATSPERB | RNA-P17T-P17T-8 | Human | Lung | IAC | 1.71e-04 | 6.46e-01 | 0.3329 |
79820 | CATSPERB | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 2.14e-02 | 3.64e-01 | -0.2119 |
79820 | CATSPERB | RNA-P7T1-P7T1-1 | Human | Lung | AIS | 4.09e-03 | 5.38e-01 | -0.0961 |
79820 | CATSPERB | RNA-P7T1-P7T1-2 | Human | Lung | AIS | 1.30e-02 | 4.68e-01 | -0.0876 |
79820 | CATSPERB | RNA-P7T1-P7T1-3 | Human | Lung | AIS | 2.29e-05 | 6.87e-01 | -0.0822 |
79820 | CATSPERB | RNA-P7T1-P7T1-4 | Human | Lung | AIS | 1.32e-05 | 5.98e-01 | -0.0809 |
79820 | CATSPERB | HTA12-16-5 | Human | Pancreas | PDAC | 2.59e-04 | 5.90e-01 | 0.047 |
79820 | CATSPERB | HTA12-18-3 | Human | Pancreas | PDAC | 4.30e-02 | 5.11e-01 | 0.0716 |
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Tissue | Expression Dynamics | Abbreviation |
Lung | ![]() | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ | ||
IAC: Invasive lung adenocarcinoma | ||
MIA: Minimally invasive adenocarcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CATSPERB | SNV | Missense_Mutation | c.2606N>G | p.Tyr869Cys | p.Y869C | Q9H7T0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CATSPERB | SNV | Missense_Mutation | novel | c.1085N>C | p.Val362Ala | p.V362A | Q9H7T0 | protein_coding | deleterious(0) | possibly_damaging(0.655) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CATSPERB | SNV | Missense_Mutation | c.902N>T | p.Arg301Ile | p.R301I | Q9H7T0 | protein_coding | tolerated(0.11) | possibly_damaging(0.665) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CATSPERB | SNV | Missense_Mutation | rs773719104 | c.470C>T | p.Pro157Leu | p.P157L | Q9H7T0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CATSPERB | SNV | Missense_Mutation | novel | c.1831C>T | p.Pro611Ser | p.P611S | Q9H7T0 | protein_coding | deleterious(0.01) | possibly_damaging(0.785) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CATSPERB | SNV | Missense_Mutation | novel | c.560N>A | p.Cys187Tyr | p.C187Y | Q9H7T0 | protein_coding | deleterious(0) | probably_damaging(0.924) | TCGA-BG-A2L7-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR |
CATSPERB | SNV | Missense_Mutation | rs768019574 | c.1256N>A | p.Arg419Gln | p.R419Q | Q9H7T0 | protein_coding | tolerated(0.12) | probably_damaging(0.998) | TCGA-BK-A6W3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CATSPERB | SNV | Missense_Mutation | c.2652N>G | p.Asn884Lys | p.N884K | Q9H7T0 | protein_coding | deleterious(0.02) | possibly_damaging(0.801) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
CATSPERB | SNV | Missense_Mutation | novel | c.2591N>T | p.Thr864Ile | p.T864I | Q9H7T0 | protein_coding | deleterious(0.04) | benign(0.313) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CATSPERB | SNV | Missense_Mutation | novel | c.2802N>A | p.Phe934Leu | p.F934L | Q9H7T0 | protein_coding | tolerated(0.07) | probably_damaging(0.996) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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