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Gene: CAPN5 |
Gene summary for CAPN5 |
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Gene information | Species | Human | Gene symbol | CAPN5 | Gene ID | 726 |
Gene name | calpain 5 | |
Gene Alias | ADNIV | |
Cytomap | 11q13.5 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | A0A140VKH4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
726 | CAPN5 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.16e-05 | 5.63e-01 | -0.1808 |
726 | CAPN5 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.48e-02 | 2.60e-01 | -0.0811 |
726 | CAPN5 | HTA11_347_2000001011 | Human | Colorectum | AD | 6.80e-32 | 8.31e-01 | -0.1954 |
726 | CAPN5 | HTA11_411_2000001011 | Human | Colorectum | SER | 6.71e-12 | 1.35e+00 | -0.2602 |
726 | CAPN5 | HTA11_2112_2000001011 | Human | Colorectum | SER | 3.31e-04 | 8.14e-01 | -0.2196 |
726 | CAPN5 | HTA11_83_2000001011 | Human | Colorectum | SER | 3.57e-04 | 4.61e-01 | -0.1526 |
726 | CAPN5 | HTA11_696_2000001011 | Human | Colorectum | AD | 6.84e-11 | 5.93e-01 | -0.1464 |
726 | CAPN5 | HTA11_866_2000001011 | Human | Colorectum | AD | 5.13e-04 | 4.27e-01 | -0.1001 |
726 | CAPN5 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.13e-08 | 5.20e-01 | -0.059 |
726 | CAPN5 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.23e-03 | -2.40e-01 | 0.294 |
726 | CAPN5 | A002-C-010 | Human | Colorectum | FAP | 2.47e-04 | -1.78e-01 | 0.242 |
726 | CAPN5 | A015-C-203 | Human | Colorectum | FAP | 2.45e-12 | -2.12e-01 | -0.1294 |
726 | CAPN5 | A002-C-201 | Human | Colorectum | FAP | 2.31e-02 | -1.78e-01 | 0.0324 |
726 | CAPN5 | A001-C-108 | Human | Colorectum | FAP | 2.95e-06 | -2.45e-01 | -0.0272 |
726 | CAPN5 | A002-C-205 | Human | Colorectum | FAP | 4.11e-07 | -3.00e-01 | -0.1236 |
726 | CAPN5 | A001-C-104 | Human | Colorectum | FAP | 4.17e-02 | -1.53e-01 | 0.0184 |
726 | CAPN5 | A015-C-006 | Human | Colorectum | FAP | 2.49e-04 | -2.51e-01 | -0.0994 |
726 | CAPN5 | A015-C-106 | Human | Colorectum | FAP | 3.15e-07 | -1.82e-01 | -0.0511 |
726 | CAPN5 | A002-C-114 | Human | Colorectum | FAP | 2.42e-04 | -2.33e-01 | -0.1561 |
726 | CAPN5 | A015-C-104 | Human | Colorectum | FAP | 7.70e-13 | -2.68e-01 | -0.1899 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CAPN5 | SNV | Missense_Mutation | c.1113G>C | p.Gln371His | p.Q371H | O15484 | protein_coding | tolerated(0.57) | possibly_damaging(0.454) | TCGA-67-3774-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CAPN5 | SNV | Missense_Mutation | c.1704C>G | p.Phe568Leu | p.F568L | O15484 | protein_coding | deleterious(0.03) | probably_damaging(0.998) | TCGA-78-7154-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
CAPN5 | SNV | Missense_Mutation | rs141138795 | c.1709G>A | p.Arg570His | p.R570H | O15484 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-22-5479-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | SD |
CAPN5 | SNV | Missense_Mutation | novel | c.1651N>C | p.Ser551Pro | p.S551P | O15484 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-56-7730-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | unknown | PD |
CAPN5 | SNV | Missense_Mutation | novel | c.350N>T | p.Tyr117Phe | p.Y117F | O15484 | protein_coding | deleterious(0) | possibly_damaging(0.704) | TCGA-56-8307-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CAPN5 | SNV | Missense_Mutation | novel | c.431N>G | p.Asn144Ser | p.N144S | O15484 | protein_coding | deleterious(0.04) | benign(0.441) | TCGA-60-2696-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CAPN5 | SNV | Missense_Mutation | novel | c.1468G>A | p.Asp490Asn | p.D490N | O15484 | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-CV-A468-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CAPN5 | SNV | Missense_Mutation | rs781940282 | c.128N>A | p.Gly43Asp | p.G43D | O15484 | protein_coding | tolerated(0.58) | benign(0.119) | TCGA-CV-A6JD-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CAPN5 | SNV | Missense_Mutation | novel | c.257C>G | p.Ala86Gly | p.A86G | O15484 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CH-5752-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 8 | Hormone Therapy | leuprorelin | SD |
CAPN5 | SNV | Missense_Mutation | rs782178755 | c.353N>T | p.Ala118Val | p.A118V | O15484 | protein_coding | deleterious(0.05) | benign(0.044) | TCGA-KK-A8I4-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Hormone Therapy | lupron | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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