![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: BTBD3 |
Gene summary for BTBD3 |
![]() |
Gene information | Species | Human | Gene symbol | BTBD3 | Gene ID | 22903 |
Gene name | BTB domain containing 3 | |
Gene Alias | dJ742J24.1 | |
Cytomap | 20p12.2 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | B4DRI6 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
22903 | BTBD3 | LZE4T | Human | Esophagus | ESCC | 1.93e-02 | 4.19e-02 | 0.0811 |
22903 | BTBD3 | LZE5T | Human | Esophagus | ESCC | 3.66e-02 | 2.51e-01 | 0.0514 |
22903 | BTBD3 | LZE24T | Human | Esophagus | ESCC | 2.14e-02 | 7.05e-02 | 0.0596 |
22903 | BTBD3 | P1T-E | Human | Esophagus | ESCC | 3.48e-02 | 1.27e-01 | 0.0875 |
22903 | BTBD3 | P2T-E | Human | Esophagus | ESCC | 1.22e-15 | 2.42e-01 | 0.1177 |
22903 | BTBD3 | P4T-E | Human | Esophagus | ESCC | 1.66e-06 | 1.65e-01 | 0.1323 |
22903 | BTBD3 | P5T-E | Human | Esophagus | ESCC | 1.18e-13 | 1.83e-01 | 0.1327 |
22903 | BTBD3 | P8T-E | Human | Esophagus | ESCC | 1.99e-06 | 1.30e-01 | 0.0889 |
22903 | BTBD3 | P9T-E | Human | Esophagus | ESCC | 4.72e-12 | 1.51e-01 | 0.1131 |
22903 | BTBD3 | P10T-E | Human | Esophagus | ESCC | 1.16e-20 | 3.64e-01 | 0.116 |
22903 | BTBD3 | P11T-E | Human | Esophagus | ESCC | 6.52e-08 | 3.57e-01 | 0.1426 |
22903 | BTBD3 | P12T-E | Human | Esophagus | ESCC | 6.51e-11 | 2.39e-01 | 0.1122 |
22903 | BTBD3 | P15T-E | Human | Esophagus | ESCC | 4.69e-07 | 1.17e-01 | 0.1149 |
22903 | BTBD3 | P16T-E | Human | Esophagus | ESCC | 1.22e-26 | 4.93e-01 | 0.1153 |
22903 | BTBD3 | P19T-E | Human | Esophagus | ESCC | 4.66e-05 | 2.25e-01 | 0.1662 |
22903 | BTBD3 | P20T-E | Human | Esophagus | ESCC | 4.48e-10 | 1.87e-01 | 0.1124 |
22903 | BTBD3 | P21T-E | Human | Esophagus | ESCC | 6.01e-07 | 1.71e-01 | 0.1617 |
22903 | BTBD3 | P22T-E | Human | Esophagus | ESCC | 8.16e-11 | 1.28e-01 | 0.1236 |
22903 | BTBD3 | P23T-E | Human | Esophagus | ESCC | 5.49e-15 | 4.74e-01 | 0.108 |
22903 | BTBD3 | P24T-E | Human | Esophagus | ESCC | 5.72e-09 | 9.84e-02 | 0.1287 |
Page: 1 2 3 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00215436 | Esophagus | ESCC | pallium development | 94/8552 | 169/18723 | 5.79e-03 | 2.14e-02 | 94 |
GO:001635816 | Esophagus | ESCC | dendrite development | 130/8552 | 243/18723 | 8.33e-03 | 2.95e-02 | 130 |
GO:00163586 | Lung | IAC | dendrite development | 55/2061 | 243/18723 | 1.35e-07 | 1.18e-05 | 55 |
GO:00488134 | Lung | IAC | dendrite morphogenesis | 34/2061 | 146/18723 | 1.68e-05 | 4.79e-04 | 34 |
GO:00219872 | Lung | IAC | cerebral cortex development | 27/2061 | 114/18723 | 8.78e-05 | 1.77e-03 | 27 |
GO:00215432 | Lung | IAC | pallium development | 33/2061 | 169/18723 | 7.51e-04 | 9.82e-03 | 33 |
GO:00309002 | Lung | IAC | forebrain development | 61/2061 | 379/18723 | 1.52e-03 | 1.61e-02 | 61 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BTBD3 | SNV | Missense_Mutation | novel | c.773C>A | p.Ser258Tyr | p.S258Y | Q9Y2F9 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-CN-5359-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
BTBD3 | SNV | Missense_Mutation | novel | c.938T>A | p.Leu313Gln | p.L313Q | Q9Y2F9 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-CV-7418-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
BTBD3 | SNV | Missense_Mutation | c.183N>T | p.Lys61Asn | p.K61N | Q9Y2F9 | protein_coding | deleterious_low_confidence(0.01) | benign(0.203) | TCGA-D6-A4Z9-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
BTBD3 | SNV | Missense_Mutation | rs530038210 | c.821G>A | p.Arg274His | p.R274H | Q9Y2F9 | protein_coding | deleterious(0.05) | benign(0.009) | TCGA-QK-A8Z8-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | PD |
BTBD3 | SNV | Missense_Mutation | novel | c.1391N>G | p.Asp464Gly | p.D464G | Q9Y2F9 | protein_coding | tolerated(0.19) | benign(0.261) | TCGA-ZG-A9L1-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | SD |
BTBD3 | SNV | Missense_Mutation | rs776639503 | c.62N>T | p.Thr21Met | p.T21M | Q9Y2F9 | protein_coding | deleterious_low_confidence(0.01) | benign(0.412) | TCGA-BR-4280-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
BTBD3 | SNV | Missense_Mutation | c.331N>T | p.Ala111Ser | p.A111S | Q9Y2F9 | protein_coding | tolerated(0.3) | benign(0.054) | TCGA-CG-4477-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
BTBD3 | SNV | Missense_Mutation | novel | c.758N>G | p.Glu253Gly | p.E253G | Q9Y2F9 | protein_coding | tolerated(0.17) | probably_damaging(0.967) | TCGA-FP-A4BE-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
BTBD3 | SNV | Missense_Mutation | c.203N>T | p.Pro68Leu | p.P68L | Q9Y2F9 | protein_coding | deleterious_low_confidence(0) | benign(0.001) | TCGA-IN-A6RI-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
BTBD3 | insertion | Frame_Shift_Ins | novel | c.171_172insA | p.Lys60GlufsTer6 | p.K60Efs*6 | Q9Y2F9 | protein_coding | TCGA-F1-6874-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |