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Gene: BIVM |
Gene summary for BIVM |
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Gene information | Species | Human | Gene symbol | BIVM | Gene ID | 54841 |
Gene name | basic, immunoglobulin-like variable motif containing | |
Gene Alias | BIVM | |
Cytomap | 13q33.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q86UB2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54841 | BIVM | HTA11_3410_2000001011 | Human | Colorectum | AD | 7.98e-03 | 1.08e-01 | 0.0155 |
54841 | BIVM | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.87e-02 | 1.26e-01 | -0.1808 |
54841 | BIVM | HTA11_1938_2000001011 | Human | Colorectum | AD | 8.58e-13 | 3.82e-01 | -0.0811 |
54841 | BIVM | HTA11_78_2000001011 | Human | Colorectum | AD | 6.85e-15 | 3.72e-01 | -0.1088 |
54841 | BIVM | HTA11_347_2000001011 | Human | Colorectum | AD | 1.27e-24 | 4.42e-01 | -0.1954 |
54841 | BIVM | HTA11_3361_2000001011 | Human | Colorectum | AD | 5.46e-03 | 1.57e-01 | -0.1207 |
54841 | BIVM | HTA11_83_2000001011 | Human | Colorectum | SER | 8.73e-04 | 2.04e-01 | -0.1526 |
54841 | BIVM | HTA11_696_2000001011 | Human | Colorectum | AD | 3.83e-12 | 2.54e-01 | -0.1464 |
54841 | BIVM | HTA11_866_2000001011 | Human | Colorectum | AD | 9.63e-08 | 1.81e-01 | -0.1001 |
54841 | BIVM | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.72e-12 | 2.91e-01 | -0.059 |
54841 | BIVM | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.09e-02 | 2.63e-01 | -0.1706 |
54841 | BIVM | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.28e-02 | 1.93e-01 | -0.2061 |
54841 | BIVM | HTA11_546_2000001011 | Human | Colorectum | AD | 4.83e-05 | 3.33e-01 | -0.0842 |
54841 | BIVM | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.12e-06 | 2.70e-01 | -0.0179 |
54841 | BIVM | HTA11_866_3004761011 | Human | Colorectum | AD | 9.76e-05 | 1.54e-01 | 0.096 |
54841 | BIVM | HTA11_4255_2000001011 | Human | Colorectum | SER | 3.22e-05 | 3.08e-01 | 0.0446 |
54841 | BIVM | HTA11_10623_2000001011 | Human | Colorectum | AD | 6.46e-07 | 3.17e-01 | -0.0177 |
54841 | BIVM | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.62e-06 | 2.12e-01 | 0.0338 |
54841 | BIVM | HTA11_7696_3000711011 | Human | Colorectum | AD | 8.94e-11 | 2.48e-01 | 0.0674 |
54841 | BIVM | HTA11_6818_2000001021 | Human | Colorectum | AD | 6.03e-04 | 1.82e-01 | 0.0588 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BIVM | SNV | Missense_Mutation | c.1500N>A | p.Asp500Glu | p.D500E | Q86UB2 | protein_coding | tolerated_low_confidence(0.29) | benign(0.001) | TCGA-66-2787-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
BIVM | SNV | Missense_Mutation | c.1501N>T | p.Gly501Trp | p.G501W | Q86UB2 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.958) | TCGA-66-2787-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
BIVM | SNV | Missense_Mutation | novel | c.627G>T | p.Gln209His | p.Q209H | Q86UB2 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-85-6561-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | SD |
BIVM | SNV | Missense_Mutation | novel | c.61G>A | p.Glu21Lys | p.E21K | Q86UB2 | protein_coding | tolerated_low_confidence(0.65) | benign(0.011) | TCGA-NK-A5CR-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
BIVM | SNV | Missense_Mutation | novel | c.688N>G | p.Met230Val | p.M230V | Q86UB2 | protein_coding | deleterious(0.05) | benign(0.036) | TCGA-CV-A45Z-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
BIVM | SNV | Missense_Mutation | novel | c.532N>G | p.Tyr178Asp | p.Y178D | Q86UB2 | protein_coding | tolerated(0.2) | benign(0.006) | TCGA-KK-A8IM-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
BIVM | SNV | Missense_Mutation | c.897N>C | p.Glu299Asp | p.E299D | Q86UB2 | protein_coding | tolerated(0.06) | probably_damaging(0.987) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
BIVM | SNV | Missense_Mutation | c.139N>T | p.Pro47Ser | p.P47S | Q86UB2 | protein_coding | tolerated_low_confidence(0.93) | benign(0.001) | TCGA-BR-8382-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
BIVM | SNV | Missense_Mutation | c.198N>G | p.Ile66Met | p.I66M | Q86UB2 | protein_coding | deleterious_low_confidence(0.02) | benign(0.255) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
BIVM | SNV | Missense_Mutation | c.560N>G | p.Pro187Arg | p.P187R | Q86UB2 | protein_coding | deleterious(0.02) | benign(0.063) | TCGA-CG-4449-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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