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Gene: ARSE |
Gene summary for ARSE |
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Gene information | Species | Human | Gene symbol | ARSE | Gene ID | 415 |
Gene name | arylsulfatase L | |
Gene Alias | ARSE | |
Cytomap | Xp22.33 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | P51690 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
415 | ARSE | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.26e-04 | -2.00e-01 | 0.0155 |
415 | ARSE | HTA11_78_2000001011 | Human | Colorectum | AD | 4.20e-02 | -2.00e-01 | -0.1088 |
415 | ARSE | HTA11_347_2000001011 | Human | Colorectum | AD | 9.99e-05 | -2.00e-01 | -0.1954 |
415 | ARSE | HTA11_696_2000001011 | Human | Colorectum | AD | 4.40e-09 | -2.00e-01 | -0.1464 |
415 | ARSE | HTA11_866_2000001011 | Human | Colorectum | AD | 9.55e-09 | -2.00e-01 | -0.1001 |
415 | ARSE | HTA11_1391_2000001011 | Human | Colorectum | AD | 6.84e-03 | -2.00e-01 | -0.059 |
415 | ARSE | HTA11_866_3004761011 | Human | Colorectum | AD | 2.14e-03 | -2.00e-01 | 0.096 |
415 | ARSE | HTA11_7696_3000711011 | Human | Colorectum | AD | 9.55e-09 | -2.00e-01 | 0.0674 |
415 | ARSE | HTA11_99999965104_69814 | Human | Colorectum | MSS | 4.21e-15 | 7.01e-01 | 0.281 |
415 | ARSE | HTA11_99999973899_84307 | Human | Colorectum | MSS | 9.37e-12 | 7.25e-01 | 0.2585 |
415 | ARSE | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.67e-14 | 6.08e-01 | 0.3005 |
415 | ARSE | A015-C-104 | Human | Colorectum | FAP | 1.70e-02 | 8.83e-02 | -0.1899 |
415 | ARSE | A002-C-116 | Human | Colorectum | FAP | 7.57e-04 | -3.45e-02 | -0.0452 |
415 | ARSE | CRC-3-11773 | Human | Colorectum | CRC | 1.08e-04 | -1.49e-01 | 0.2564 |
415 | ARSE | S43 | Human | Liver | Cirrhotic | 2.45e-05 | 1.19e-02 | -0.0187 |
415 | ARSE | HCC1_Meng | Human | Liver | HCC | 1.47e-77 | 1.78e-01 | 0.0246 |
415 | ARSE | HCC2_Meng | Human | Liver | HCC | 2.08e-19 | -1.32e-02 | 0.0107 |
415 | ARSE | cirrhotic1 | Human | Liver | Cirrhotic | 9.98e-12 | 3.13e-01 | 0.0202 |
415 | ARSE | cirrhotic2 | Human | Liver | Cirrhotic | 4.27e-08 | 1.82e-01 | 0.0201 |
415 | ARSE | HCC1 | Human | Liver | HCC | 6.73e-03 | 3.92e+00 | 0.5336 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARSE | SNV | Missense_Mutation | novel | c.1246N>T | p.Gly416Trp | p.G416W | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-E8-A2EA-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ARSE | insertion | Frame_Shift_Ins | novel | c.643_644insAGAATAAGGG | p.Arg215GlnfsTer101 | p.R215Qfs*101 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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