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Gene: ARMC3 |
Gene summary for ARMC3 |
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Gene information | Species | Human | Gene symbol | ARMC3 | Gene ID | 219681 |
Gene name | armadillo repeat containing 3 | |
Gene Alias | CT81 | |
Cytomap | 10p12.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q5W041 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
219681 | ARMC3 | RNA-P6T1-P6T1-1 | Human | Lung | MIAC | 3.00e-03 | 7.47e-01 | -0.0238 |
219681 | ARMC3 | RNA-P6T1-P6T1-2 | Human | Lung | MIAC | 4.12e-03 | 6.53e-01 | -0.0186 |
219681 | ARMC3 | RNA-P6T1-P6T1-3 | Human | Lung | MIAC | 3.47e-02 | 7.14e-01 | -0.0296 |
219681 | ARMC3 | RNA-P6T1-P6T1-4 | Human | Lung | MIAC | 2.24e-04 | 7.21e-01 | -0.0263 |
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Tissue | Expression Dynamics | Abbreviation |
Lung | ![]() | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ | ||
IAC: Invasive lung adenocarcinoma | ||
MIA: Minimally invasive adenocarcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARMC3 | SNV | Missense_Mutation | c.1852G>T | p.Asp618Tyr | p.D618Y | Q5W041 | protein_coding | deleterious(0.01) | possibly_damaging(0.781) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
ARMC3 | SNV | Missense_Mutation | c.380A>G | p.Glu127Gly | p.E127G | Q5W041 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-D1-A0ZO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ARMC3 | SNV | Missense_Mutation | rs770918945 | c.1741G>A | p.Gly581Ser | p.G581S | Q5W041 | protein_coding | deleterious(0.03) | benign(0.026) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARMC3 | SNV | Missense_Mutation | rs150029689 | c.2023G>A | p.Ala675Thr | p.A675T | Q5W041 | protein_coding | tolerated(0.49) | benign(0) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARMC3 | SNV | Missense_Mutation | c.2169C>A | p.Phe723Leu | p.F723L | Q5W041 | protein_coding | tolerated(1) | benign(0.007) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ARMC3 | SNV | Missense_Mutation | c.429N>C | p.Lys143Asn | p.K143N | Q5W041 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-D1-A16X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ARMC3 | SNV | Missense_Mutation | novel | c.2017N>G | p.Lys673Glu | p.K673E | Q5W041 | protein_coding | tolerated(0.38) | benign(0.197) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
ARMC3 | SNV | Missense_Mutation | novel | c.2297A>G | p.Asp766Gly | p.D766G | Q5W041 | protein_coding | tolerated(0.09) | benign(0.033) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
ARMC3 | SNV | Missense_Mutation | novel | c.2242G>A | p.Ala748Thr | p.A748T | Q5W041 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
ARMC3 | SNV | Missense_Mutation | c.1880N>A | p.Ser627Asn | p.S627N | Q5W041 | protein_coding | tolerated(0.27) | benign(0.169) | TCGA-E6-A1M0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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