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Gene: ARHGAP27 |
Gene summary for ARHGAP27 |
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Gene information | Species | Human | Gene symbol | ARHGAP27 | Gene ID | 201176 |
Gene name | Rho GTPase activating protein 27 | |
Gene Alias | CAMGAP1 | |
Cytomap | 17q21.31 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q6ZUM4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
201176 | ARHGAP27 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.37e-02 | -2.46e-01 | 0.0155 |
201176 | ARHGAP27 | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.84e-05 | 5.07e-01 | -0.1808 |
201176 | ARHGAP27 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.64e-04 | 3.37e-01 | -0.1954 |
201176 | ARHGAP27 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.19e-02 | 4.41e-01 | -0.059 |
201176 | ARHGAP27 | A002-C-010 | Human | Colorectum | FAP | 2.34e-03 | -1.85e-01 | 0.242 |
201176 | ARHGAP27 | A015-C-203 | Human | Colorectum | FAP | 1.24e-14 | -1.27e-01 | -0.1294 |
201176 | ARHGAP27 | A002-C-201 | Human | Colorectum | FAP | 2.78e-03 | -1.25e-01 | 0.0324 |
201176 | ARHGAP27 | A001-C-119 | Human | Colorectum | FAP | 2.43e-05 | -3.53e-01 | -0.1557 |
201176 | ARHGAP27 | A001-C-108 | Human | Colorectum | FAP | 4.72e-08 | -1.63e-01 | -0.0272 |
201176 | ARHGAP27 | A002-C-205 | Human | Colorectum | FAP | 3.58e-09 | -2.10e-01 | -0.1236 |
201176 | ARHGAP27 | A015-C-006 | Human | Colorectum | FAP | 6.13e-06 | -2.81e-01 | -0.0994 |
201176 | ARHGAP27 | A015-C-106 | Human | Colorectum | FAP | 1.30e-04 | -1.24e-01 | -0.0511 |
201176 | ARHGAP27 | A002-C-114 | Human | Colorectum | FAP | 6.41e-07 | -8.13e-02 | -0.1561 |
201176 | ARHGAP27 | A015-C-104 | Human | Colorectum | FAP | 3.54e-16 | -2.66e-01 | -0.1899 |
201176 | ARHGAP27 | A001-C-014 | Human | Colorectum | FAP | 3.99e-04 | -1.25e-01 | 0.0135 |
201176 | ARHGAP27 | A002-C-016 | Human | Colorectum | FAP | 1.70e-15 | -2.94e-01 | 0.0521 |
201176 | ARHGAP27 | A015-C-002 | Human | Colorectum | FAP | 1.16e-02 | -5.99e-02 | -0.0763 |
201176 | ARHGAP27 | A001-C-203 | Human | Colorectum | FAP | 4.24e-05 | -5.81e-02 | -0.0481 |
201176 | ARHGAP27 | A002-C-116 | Human | Colorectum | FAP | 2.54e-19 | -2.66e-01 | -0.0452 |
201176 | ARHGAP27 | A014-C-008 | Human | Colorectum | FAP | 1.11e-05 | -2.59e-01 | -0.191 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0043087 | Colorectum | AD | regulation of GTPase activity | 110/3918 | 348/18723 | 1.64e-06 | 5.03e-05 | 110 |
GO:0051056 | Colorectum | AD | regulation of small GTPase mediated signal transduction | 94/3918 | 302/18723 | 1.81e-05 | 3.76e-04 | 94 |
GO:0006898 | Colorectum | AD | receptor-mediated endocytosis | 76/3918 | 244/18723 | 1.07e-04 | 1.59e-03 | 76 |
GO:0043547 | Colorectum | AD | positive regulation of GTPase activity | 75/3918 | 255/18723 | 7.95e-04 | 7.91e-03 | 75 |
GO:00430871 | Colorectum | SER | regulation of GTPase activity | 77/2897 | 348/18723 | 5.90e-04 | 8.07e-03 | 77 |
GO:00510562 | Colorectum | FAP | regulation of small GTPase mediated signal transduction | 78/2622 | 302/18723 | 3.25e-08 | 2.85e-06 | 78 |
GO:00430873 | Colorectum | FAP | regulation of GTPase activity | 85/2622 | 348/18723 | 1.20e-07 | 7.68e-06 | 85 |
GO:00068982 | Colorectum | FAP | receptor-mediated endocytosis | 62/2622 | 244/18723 | 1.47e-06 | 6.39e-05 | 62 |
GO:00435472 | Colorectum | FAP | positive regulation of GTPase activity | 61/2622 | 255/18723 | 1.39e-05 | 3.73e-04 | 61 |
GO:000689810 | Oral cavity | OSCC | receptor-mediated endocytosis | 125/7305 | 244/18723 | 6.56e-05 | 5.32e-04 | 125 |
GO:004308710 | Oral cavity | OSCC | regulation of GTPase activity | 165/7305 | 348/18723 | 7.94e-04 | 4.27e-03 | 165 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARHGAP27 | SNV | Missense_Mutation | novel | c.1543N>A | p.Leu515Ile | p.L515I | Q6ZUM4 | protein_coding | deleterious(0.01) | possibly_damaging(0.468) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
ARHGAP27 | deletion | Frame_Shift_Del | novel | c.1346delN | p.Pro449LeufsTer44 | p.P449Lfs*44 | Q6ZUM4 | protein_coding | TCGA-CG-5724-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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