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Gene: ANO7 |
Gene summary for ANO7 |
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Gene information | Species | Human | Gene symbol | ANO7 | Gene ID | 50636 |
Gene name | anoctamin 7 | |
Gene Alias | D-TMPP | |
Cytomap | 2q37.3 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q6IWH7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
50636 | ANO7 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.79e-02 | 2.17e-01 | -0.1088 |
50636 | ANO7 | HTA11_2112_2000001011 | Human | Colorectum | SER | 7.02e-03 | 4.42e-01 | -0.2196 |
50636 | ANO7 | HTA11_3361_2000001011 | Human | Colorectum | AD | 9.33e-05 | 3.59e-01 | -0.1207 |
50636 | ANO7 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.92e-11 | 4.11e-01 | -0.1464 |
50636 | ANO7 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.31e-07 | 2.60e-01 | -0.1001 |
50636 | ANO7 | P15T-E | Human | Esophagus | ESCC | 1.14e-06 | 1.32e-01 | 0.1149 |
50636 | ANO7 | P16T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.14e-01 | 0.1153 |
50636 | ANO7 | P21T-E | Human | Esophagus | ESCC | 3.89e-12 | 2.12e-01 | 0.1617 |
50636 | ANO7 | P28T-E | Human | Esophagus | ESCC | 8.84e-05 | 1.26e-01 | 0.1149 |
50636 | ANO7 | P49T-E | Human | Esophagus | ESCC | 1.65e-02 | 2.14e-01 | 0.1768 |
50636 | ANO7 | P62T-E | Human | Esophagus | ESCC | 1.36e-04 | 6.56e-02 | 0.1302 |
50636 | ANO7 | P74T-E | Human | Esophagus | ESCC | 4.38e-05 | 1.27e-01 | 0.1479 |
50636 | ANO7 | P76T-E | Human | Esophagus | ESCC | 4.17e-05 | 1.35e-01 | 0.1207 |
50636 | ANO7 | P79T-E | Human | Esophagus | ESCC | 3.75e-03 | 7.32e-02 | 0.1154 |
50636 | ANO7 | P82T-E | Human | Esophagus | ESCC | 4.27e-06 | 2.23e-01 | 0.1072 |
50636 | ANO7 | P83T-E | Human | Esophagus | ESCC | 7.64e-05 | 1.74e-01 | 0.1738 |
50636 | ANO7 | P89T-E | Human | Esophagus | ESCC | 2.04e-03 | 2.45e-01 | 0.1752 |
50636 | ANO7 | P94T-E | Human | Esophagus | ESCC | 1.43e-02 | 5.38e-01 | 0.0879 |
50636 | ANO7 | P104T-E | Human | Esophagus | ESCC | 4.22e-12 | 5.60e-01 | 0.0931 |
50636 | ANO7 | P107T-E | Human | Esophagus | ESCC | 3.88e-05 | 8.81e-02 | 0.171 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010876 | Colorectum | AD | lipid localization | 120/3918 | 448/18723 | 1.59e-03 | 1.33e-02 | 120 |
GO:0006869 | Colorectum | AD | lipid transport | 108/3918 | 398/18723 | 1.67e-03 | 1.39e-02 | 108 |
GO:0015698 | Colorectum | AD | inorganic anion transport | 52/3918 | 180/18723 | 6.83e-03 | 4.22e-02 | 52 |
GO:0015748 | Colorectum | AD | organophosphate ester transport | 42/3918 | 140/18723 | 7.04e-03 | 4.31e-02 | 42 |
GO:0007009 | Colorectum | SER | plasma membrane organization | 36/2897 | 142/18723 | 1.50e-03 | 1.62e-02 | 36 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ANO7 | insertion | Frame_Shift_Ins | novel | c.343_344insT | p.Trp116LeufsTer32 | p.W116Lfs*32 | Q6IWH7 | protein_coding | TCGA-AP-A05O-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD | ||
ANO7 | SNV | Missense_Mutation | rs199644599 | c.377A>G | p.Gln126Arg | p.Q126R | Q6IWH7 | protein_coding | tolerated(0.39) | benign(0) | TCGA-2V-A95S-01 | Liver | liver hepatocellular carcinoma | Male | Unknown | I/II | Unknown | Unknown | SD |
ANO7 | SNV | Missense_Mutation | c.1271N>C | p.Val424Ala | p.V424A | Q6IWH7 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-MI-A75I-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
ANO7 | SNV | Missense_Mutation | c.964C>A | p.Arg322Ser | p.R322S | Q6IWH7 | protein_coding | tolerated(0.07) | benign(0.243) | TCGA-05-4432-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR | |
ANO7 | SNV | Missense_Mutation | c.827T>C | p.Leu276Pro | p.L276P | Q6IWH7 | protein_coding | deleterious(0.01) | benign(0.445) | TCGA-35-3615-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ANO7 | SNV | Missense_Mutation | novel | c.1592N>A | p.Arg531Lys | p.R531K | Q6IWH7 | protein_coding | tolerated(0.71) | benign(0.015) | TCGA-44-7667-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ANO7 | SNV | Missense_Mutation | c.1593G>T | p.Arg531Ser | p.R531S | Q6IWH7 | protein_coding | tolerated(0.45) | benign(0.253) | TCGA-44-8117-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ANO7 | SNV | Missense_Mutation | c.1394N>T | p.Arg465Leu | p.R465L | Q6IWH7 | protein_coding | deleterious(0.04) | possibly_damaging(0.864) | TCGA-49-AARQ-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ANO7 | SNV | Missense_Mutation | c.1232N>A | p.Leu411Gln | p.L411Q | Q6IWH7 | protein_coding | tolerated(0.1) | benign(0.183) | TCGA-50-5946-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
ANO7 | SNV | Missense_Mutation | c.1123N>T | p.Val375Leu | p.V375L | Q6IWH7 | protein_coding | tolerated(0.3) | benign(0.022) | TCGA-55-8507-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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