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Gene: ANO4 |
Gene summary for ANO4 |
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Gene information | Species | Human | Gene symbol | ANO4 | Gene ID | 121601 |
Gene name | anoctamin 4 | |
Gene Alias | TMEM16D | |
Cytomap | 12q23.1 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | B7Z9Z0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
121601 | ANO4 | ATC13 | Human | Thyroid | ATC | 3.04e-38 | 6.37e-01 | 0.34 |
121601 | ANO4 | ATC5 | Human | Thyroid | ATC | 2.12e-37 | 6.83e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ANO4 | SNV | Missense_Mutation | rs771044930 | c.1021N>T | p.Arg341Trp | p.R341W | Q32M45 | protein_coding | deleterious(0) | probably_damaging(0.959) | TCGA-AP-A05O-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
ANO4 | SNV | Missense_Mutation | c.1378N>T | p.Asp460Tyr | p.D460Y | Q32M45 | protein_coding | deleterious(0) | possibly_damaging(0.774) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
ANO4 | SNV | Missense_Mutation | novel | c.2297N>G | p.Asp766Gly | p.D766G | Q32M45 | protein_coding | deleterious(0.04) | possibly_damaging(0.844) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
ANO4 | SNV | Missense_Mutation | rs765241694 | c.2393G>A | p.Arg798His | p.R798H | Q32M45 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ANO4 | SNV | Missense_Mutation | novel | c.332A>G | p.Tyr111Cys | p.Y111C | Q32M45 | protein_coding | deleterious(0.03) | benign(0.001) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
ANO4 | SNV | Missense_Mutation | c.2320N>A | p.Leu774Ile | p.L774I | Q32M45 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
ANO4 | SNV | Missense_Mutation | c.2708N>T | p.Ser903Leu | p.S903L | Q32M45 | protein_coding | deleterious(0) | benign(0.257) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
ANO4 | SNV | Missense_Mutation | c.2152N>A | p.Leu718Ile | p.L718I | Q32M45 | protein_coding | tolerated(1) | benign(0.429) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ANO4 | SNV | Missense_Mutation | rs767411991 | c.1748G>A | p.Arg583His | p.R583H | Q32M45 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AX-A1C9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ANO4 | SNV | Missense_Mutation | novel | c.1472N>A | p.Pro491His | p.P491H | Q32M45 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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