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Gene: ANKS1A |
Gene summary for ANKS1A |
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Gene information | Species | Human | Gene symbol | ANKS1A | Gene ID | 23294 |
Gene name | ankyrin repeat and sterile alpha motif domain containing 1A | |
Gene Alias | ANKS1 | |
Cytomap | 6p21.31 | |
Gene Type | protein-coding | GO ID | GO:0006928 | UniProtAcc | Q05CP0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23294 | ANKS1A | CCI_1 | Human | Cervix | CC | 2.89e-06 | 8.34e-01 | 0.528 |
23294 | ANKS1A | CCI_2 | Human | Cervix | CC | 7.99e-15 | 1.26e+00 | 0.5249 |
23294 | ANKS1A | CCI_3 | Human | Cervix | CC | 1.89e-18 | 1.03e+00 | 0.516 |
23294 | ANKS1A | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.43e-14 | -5.34e-01 | 0.0155 |
23294 | ANKS1A | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.51e-02 | -3.38e-01 | -0.1808 |
23294 | ANKS1A | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.59e-02 | -6.84e-01 | 0.0216 |
23294 | ANKS1A | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.71e-03 | -3.34e-01 | -0.0811 |
23294 | ANKS1A | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.50e-03 | -3.77e-01 | -0.1207 |
23294 | ANKS1A | HTA11_866_3004761011 | Human | Colorectum | AD | 1.53e-02 | -3.70e-01 | 0.096 |
23294 | ANKS1A | HTA11_8622_2000001021 | Human | Colorectum | SER | 2.92e-02 | -5.99e-01 | 0.0528 |
23294 | ANKS1A | HTA11_10711_2000001011 | Human | Colorectum | AD | 7.36e-03 | -3.76e-01 | 0.0338 |
23294 | ANKS1A | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.44e-06 | -4.31e-01 | 0.294 |
23294 | ANKS1A | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.68e-12 | -5.24e-01 | 0.3005 |
23294 | ANKS1A | A002-C-010 | Human | Colorectum | FAP | 3.20e-04 | -2.22e-01 | 0.242 |
23294 | ANKS1A | A001-C-207 | Human | Colorectum | FAP | 2.28e-03 | -2.56e-01 | 0.1278 |
23294 | ANKS1A | A015-C-203 | Human | Colorectum | FAP | 5.06e-39 | -6.15e-01 | -0.1294 |
23294 | ANKS1A | A015-C-204 | Human | Colorectum | FAP | 6.75e-15 | -5.21e-01 | -0.0228 |
23294 | ANKS1A | A014-C-040 | Human | Colorectum | FAP | 8.70e-10 | -7.13e-01 | -0.1184 |
23294 | ANKS1A | A002-C-201 | Human | Colorectum | FAP | 6.57e-19 | -5.07e-01 | 0.0324 |
23294 | ANKS1A | A002-C-203 | Human | Colorectum | FAP | 3.35e-06 | -2.67e-01 | 0.2786 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00069292 | Cervix | CC | substrate-dependent cell migration | 9/2311 | 23/18723 | 1.05e-03 | 8.76e-03 | 9 |
GO:00480131 | Cervix | CC | ephrin receptor signaling pathway | 14/2311 | 51/18723 | 2.78e-03 | 1.87e-02 | 14 |
GO:0048013 | Colorectum | MSS | ephrin receptor signaling pathway | 17/3467 | 51/18723 | 8.28e-03 | 4.99e-02 | 17 |
GO:0021700 | Colorectum | FAP | developmental maturation | 57/2622 | 280/18723 | 2.08e-03 | 1.72e-02 | 57 |
GO:00217001 | Colorectum | CRC | developmental maturation | 47/2078 | 280/18723 | 2.52e-03 | 2.38e-02 | 47 |
GO:0006929 | Lung | IAC | substrate-dependent cell migration | 8/2061 | 23/18723 | 2.28e-03 | 2.22e-02 | 8 |
GO:00069291 | Lung | AIS | substrate-dependent cell migration | 9/1849 | 23/18723 | 1.98e-04 | 4.07e-03 | 9 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ANKS1A | SNV | Missense_Mutation | novel | c.1497N>A | p.Phe499Leu | p.F499L | Q92625 | protein_coding | deleterious(0) | probably_damaging(0.952) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ANKS1A | SNV | Missense_Mutation | rs778083867 | c.2479N>A | p.Ala827Thr | p.A827T | Q92625 | protein_coding | deleterious(0.02) | probably_damaging(0.996) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ANKS1A | SNV | Missense_Mutation | novel | c.2170N>A | p.Asp724Asn | p.D724N | Q92625 | protein_coding | tolerated(0.45) | probably_damaging(0.993) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
ANKS1A | SNV | Missense_Mutation | novel | c.684A>C | p.Lys228Asn | p.K228N | Q92625 | protein_coding | deleterious(0.03) | benign(0.227) | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ANKS1A | SNV | Missense_Mutation | novel | c.862C>T | p.Arg288Trp | p.R288W | Q92625 | protein_coding | deleterious(0) | benign(0.402) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ANKS1A | SNV | Missense_Mutation | rs751706109 | c.3158C>T | p.Thr1053Met | p.T1053M | Q92625 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ANKS1A | SNV | Missense_Mutation | novel | c.2480N>T | p.Ala827Val | p.A827V | Q92625 | protein_coding | deleterious(0.01) | probably_damaging(0.993) | TCGA-FI-A2F4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ANKS1A | insertion | Nonsense_Mutation | novel | c.2958_2959insATCAAGTAGT | p.Tyr987IlefsTer3 | p.Y987Ifs*3 | Q92625 | protein_coding | TCGA-A5-A0R9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ANKS1A | insertion | Nonsense_Mutation | novel | c.1397_1398insAGGCCAAGGCGACAGAGCACTCTAGTTACA | p.Val466_Val467insGlyGlnGlyAspArgAlaLeuTerLeuGln | p.V466_V467insGQGDRAL*LQ | Q92625 | protein_coding | TCGA-D1-A102-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ANKS1A | deletion | Frame_Shift_Del | c.953delN | p.Pro320HisfsTer25 | p.P320Hfs*25 | Q92625 | protein_coding | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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