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Gene: ALDH1A2 |
Gene summary for ALDH1A2 |
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Gene information | Species | Human | Gene symbol | ALDH1A2 | Gene ID | 8854 |
Gene name | aldehyde dehydrogenase 1 family member A2 | |
Gene Alias | RALDH(II) | |
Cytomap | 15q21.3 | |
Gene Type | protein-coding | GO ID | GO:0001523 | UniProtAcc | O94788 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8854 | ALDH1A2 | AEH-subject1 | Human | Endometrium | AEH | 1.10e-13 | -4.57e-01 | -0.3059 |
8854 | ALDH1A2 | AEH-subject2 | Human | Endometrium | AEH | 1.53e-22 | -5.66e-01 | -0.2525 |
8854 | ALDH1A2 | AEH-subject3 | Human | Endometrium | AEH | 5.48e-24 | -5.70e-01 | -0.2576 |
8854 | ALDH1A2 | AEH-subject4 | Human | Endometrium | AEH | 7.86e-04 | -2.26e-01 | -0.2657 |
8854 | ALDH1A2 | AEH-subject5 | Human | Endometrium | AEH | 6.64e-29 | -5.96e-01 | -0.2953 |
8854 | ALDH1A2 | EEC-subject1 | Human | Endometrium | EEC | 3.67e-09 | -4.19e-01 | -0.2682 |
8854 | ALDH1A2 | EEC-subject2 | Human | Endometrium | EEC | 9.07e-29 | -5.89e-01 | -0.2607 |
8854 | ALDH1A2 | EEC-subject3 | Human | Endometrium | EEC | 9.67e-36 | -5.96e-01 | -0.2525 |
8854 | ALDH1A2 | EEC-subject4 | Human | Endometrium | EEC | 1.06e-29 | -5.87e-01 | -0.2571 |
8854 | ALDH1A2 | EEC-subject5 | Human | Endometrium | EEC | 4.08e-29 | -6.10e-01 | -0.249 |
8854 | ALDH1A2 | GSM5276934 | Human | Endometrium | EEC | 9.50e-27 | -5.40e-01 | -0.0913 |
8854 | ALDH1A2 | GSM5276935 | Human | Endometrium | EEC | 1.02e-37 | -6.42e-01 | -0.123 |
8854 | ALDH1A2 | GSM5276937 | Human | Endometrium | EEC | 1.36e-07 | -4.19e-01 | -0.0897 |
8854 | ALDH1A2 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 5.26e-30 | -6.49e-01 | -0.1869 |
8854 | ALDH1A2 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 7.98e-27 | -6.49e-01 | -0.1875 |
8854 | ALDH1A2 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 1.97e-28 | -6.34e-01 | -0.1883 |
8854 | ALDH1A2 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 1.09e-32 | -5.78e-01 | -0.1934 |
8854 | ALDH1A2 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 1.98e-39 | -6.44e-01 | -0.1917 |
8854 | ALDH1A2 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 9.37e-40 | -6.49e-01 | -0.1916 |
8854 | ALDH1A2 | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 7.60e-18 | -5.23e-01 | -0.1269 |
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Tissue | Expression Dynamics | Abbreviation |
Endometrium | ![]() | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00605376 | Endometrium | AEH | muscle tissue development | 83/2100 | 403/18723 | 2.57e-08 | 1.50e-06 | 83 |
GO:003052210 | Endometrium | AEH | intracellular receptor signaling pathway | 60/2100 | 265/18723 | 7.16e-08 | 3.77e-06 | 60 |
GO:00506738 | Endometrium | AEH | epithelial cell proliferation | 84/2100 | 437/18723 | 4.88e-07 | 1.94e-05 | 84 |
GO:004873216 | Endometrium | AEH | gland development | 83/2100 | 436/18723 | 8.62e-07 | 3.11e-05 | 83 |
GO:00147065 | Endometrium | AEH | striated muscle tissue development | 75/2100 | 384/18723 | 1.06e-06 | 3.62e-05 | 75 |
GO:00016556 | Endometrium | AEH | urogenital system development | 67/2100 | 338/18723 | 2.30e-06 | 6.76e-05 | 67 |
GO:00506788 | Endometrium | AEH | regulation of epithelial cell proliferation | 73/2100 | 381/18723 | 3.04e-06 | 8.44e-05 | 73 |
GO:00720015 | Endometrium | AEH | renal system development | 61/2100 | 302/18723 | 3.43e-06 | 9.24e-05 | 61 |
GO:00323557 | Endometrium | AEH | response to estradiol | 34/2100 | 141/18723 | 1.13e-05 | 2.53e-04 | 34 |
GO:00018224 | Endometrium | AEH | kidney development | 57/2100 | 293/18723 | 2.25e-05 | 4.35e-04 | 57 |
GO:00487625 | Endometrium | AEH | mesenchymal cell differentiation | 46/2100 | 236/18723 | 1.27e-04 | 1.74e-03 | 46 |
GO:00604853 | Endometrium | AEH | mesenchyme development | 54/2100 | 291/18723 | 1.34e-04 | 1.83e-03 | 54 |
GO:003166716 | Endometrium | AEH | response to nutrient levels | 78/2100 | 474/18723 | 3.26e-04 | 3.64e-03 | 78 |
GO:00488635 | Endometrium | AEH | stem cell differentiation | 40/2100 | 206/18723 | 3.67e-04 | 3.99e-03 | 40 |
GO:006100810 | Endometrium | AEH | hepaticobiliary system development | 31/2100 | 150/18723 | 5.41e-04 | 5.45e-03 | 31 |
GO:00351073 | Endometrium | AEH | appendage morphogenesis | 29/2100 | 138/18723 | 6.06e-04 | 5.94e-03 | 29 |
GO:00351083 | Endometrium | AEH | limb morphogenesis | 29/2100 | 138/18723 | 6.06e-04 | 5.94e-03 | 29 |
GO:00030072 | Endometrium | AEH | heart morphogenesis | 45/2100 | 246/18723 | 6.41e-04 | 6.23e-03 | 45 |
GO:0048738 | Endometrium | AEH | cardiac muscle tissue development | 43/2100 | 236/18723 | 9.06e-04 | 8.30e-03 | 43 |
GO:00487366 | Endometrium | AEH | appendage development | 33/2100 | 172/18723 | 1.41e-03 | 1.18e-02 | 33 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ALDH1A2 | SNV | Missense_Mutation | rs763114869 | c.208C>G | p.Gln70Glu | p.Q70E | O94788 | protein_coding | tolerated(0.94) | benign(0.001) | TCGA-NK-A5CT-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ALDH1A2 | SNV | Missense_Mutation | novel | c.424N>A | p.Gly142Ser | p.G142S | O94788 | protein_coding | tolerated(0.41) | benign(0.046) | TCGA-CN-5356-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
ALDH1A2 | SNV | Missense_Mutation | rs779670359 | c.1028G>A | p.Arg343Gln | p.R343Q | O94788 | protein_coding | tolerated(0.05) | possibly_damaging(0.858) | TCGA-CN-6018-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ALDH1A2 | SNV | Missense_Mutation | novel | c.1438N>A | p.Gln480Lys | p.Q480K | O94788 | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-CQ-A4CG-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
ALDH1A2 | SNV | Missense_Mutation | c.71N>G | p.His24Arg | p.H24R | O94788 | protein_coding | tolerated_low_confidence(0.39) | benign(0.01) | TCGA-CV-5434-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD | |
ALDH1A2 | SNV | Missense_Mutation | novel | c.772N>C | p.Lys258Gln | p.K258Q | O94788 | protein_coding | deleterious(0) | possibly_damaging(0.907) | TCGA-CV-A461-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ALDH1A2 | SNV | Missense_Mutation | novel | c.1035N>C | p.Lys345Asn | p.K345N | O94788 | protein_coding | deleterious(0.03) | benign(0.168) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ALDH1A2 | SNV | Missense_Mutation | novel | c.545N>G | p.Gln182Arg | p.Q182R | O94788 | protein_coding | deleterious(0.01) | probably_damaging(0.922) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
ALDH1A2 | SNV | Missense_Mutation | rs778997757 | c.1039N>T | p.Arg347Cys | p.R347C | O94788 | protein_coding | deleterious(0) | benign(0.112) | TCGA-BR-4363-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ALDH1A2 | SNV | Missense_Mutation | rs781766424 | c.734N>T | p.Thr245Met | p.T245M | O94788 | protein_coding | deleterious(0.01) | probably_damaging(0.973) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
8854 | ALDH1A2 | DRUGGABLE GENOME, ENZYME | RETINOL | RETINOL | 9666306 | |
8854 | ALDH1A2 | DRUGGABLE GENOME, ENZYME | hydrochlorothiazide | HYDROCHLOROTHIAZIDE | 29097388 | |
8854 | ALDH1A2 | DRUGGABLE GENOME, ENZYME | atenolol | ATENOLOL | 29097388 | |
8854 | ALDH1A2 | DRUGGABLE GENOME, ENZYME | VITAMIN A | 9666306,11133156 | ||
8854 | ALDH1A2 | DRUGGABLE GENOME, ENZYME | RETINOIDS | 11751205 | ||
8854 | ALDH1A2 | DRUGGABLE GENOME, ENZYME | Bisphosphonates | |||
8854 | ALDH1A2 | DRUGGABLE GENOME, ENZYME | RETINOIC ACID | 11306068,15652703,14623241 |
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