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Gene: AGTR1 |
Gene summary for AGTR1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | AGTR1 | Gene ID | 185 |
Gene name | angiotensin II receptor type 1 | |
Gene Alias | AG2S | |
Cytomap | 3q24 | |
Gene Type | protein-coding | GO ID | GO:0001525 | UniProtAcc | P30556 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
185 | AGTR1 | NAFLD1 | Human | Liver | NAFLD | 1.17e-07 | 7.31e-01 | -0.04 |
185 | AGTR1 | S43 | Human | Liver | Cirrhotic | 4.38e-02 | -1.45e-01 | -0.0187 |
185 | AGTR1 | HCC1_Meng | Human | Liver | HCC | 5.76e-70 | 1.30e-01 | 0.0246 |
185 | AGTR1 | HCC2_Meng | Human | Liver | HCC | 2.33e-07 | -2.25e-01 | 0.0107 |
185 | AGTR1 | cirrhotic1 | Human | Liver | Cirrhotic | 1.54e-02 | -1.90e-01 | 0.0202 |
185 | AGTR1 | Pt13.b | Human | Liver | HCC | 1.38e-02 | -8.70e-03 | 0.0251 |
185 | AGTR1 | S027 | Human | Liver | HCC | 7.00e-06 | 7.61e-01 | 0.2446 |
185 | AGTR1 | S028 | Human | Liver | HCC | 7.30e-10 | 6.29e-01 | 0.2503 |
185 | AGTR1 | S029 | Human | Liver | HCC | 1.83e-03 | 5.48e-01 | 0.2581 |
185 | AGTR1 | HTA12-25-1 | Human | Pancreas | PDAC | 3.64e-05 | 4.65e-01 | 0.313 |
185 | AGTR1 | HTA12-26-1 | Human | Pancreas | PDAC | 1.03e-14 | 6.63e-01 | 0.3728 |
185 | AGTR1 | HTA12-29-1 | Human | Pancreas | PDAC | 6.39e-34 | 7.97e-01 | 0.3722 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Liver | HCC: Hepatocellular carcinoma | |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00713755 | Liver | NAFLD | cellular response to peptide hormone stimulus | 65/1882 | 290/18723 | 3.95e-10 | 9.62e-08 | 65 |
GO:00082023 | Liver | NAFLD | steroid metabolic process | 69/1882 | 319/18723 | 5.90e-10 | 1.28e-07 | 69 |
GO:00160327 | Liver | NAFLD | viral process | 80/1882 | 415/18723 | 7.71e-09 | 1.07e-06 | 80 |
GO:19016536 | Liver | NAFLD | cellular response to peptide | 71/1882 | 359/18723 | 1.82e-08 | 2.09e-06 | 71 |
GO:00302585 | Liver | NAFLD | lipid modification | 49/1882 | 212/18723 | 1.97e-08 | 2.17e-06 | 49 |
GO:00072654 | Liver | NAFLD | Ras protein signal transduction | 66/1882 | 337/18723 | 8.43e-08 | 7.09e-06 | 66 |
GO:00434346 | Liver | NAFLD | response to peptide hormone | 76/1882 | 414/18723 | 1.51e-07 | 1.09e-05 | 76 |
GO:00160495 | Liver | NAFLD | cell growth | 85/1882 | 482/18723 | 1.75e-07 | 1.25e-05 | 85 |
GO:00108765 | Liver | NAFLD | lipid localization | 79/1882 | 448/18723 | 4.75e-07 | 2.92e-05 | 79 |
GO:00068694 | Liver | NAFLD | lipid transport | 71/1882 | 398/18723 | 1.16e-06 | 5.59e-05 | 71 |
GO:00192163 | Liver | NAFLD | regulation of lipid metabolic process | 61/1882 | 331/18723 | 2.18e-06 | 9.24e-05 | 61 |
GO:00718252 | Liver | NAFLD | protein-lipid complex subunit organization | 17/1882 | 50/18723 | 3.92e-06 | 1.54e-04 | 17 |
GO:00718272 | Liver | NAFLD | plasma lipoprotein particle organization | 16/1882 | 46/18723 | 5.37e-06 | 1.95e-04 | 16 |
GO:00190587 | Liver | NAFLD | viral life cycle | 57/1882 | 317/18723 | 1.00e-05 | 3.18e-04 | 57 |
GO:00072664 | Liver | NAFLD | Rho protein signal transduction | 31/1882 | 137/18723 | 1.19e-05 | 3.67e-04 | 31 |
GO:00343682 | Liver | NAFLD | protein-lipid complex remodeling | 12/1882 | 30/18723 | 1.58e-05 | 4.56e-04 | 12 |
GO:00343692 | Liver | NAFLD | plasma lipoprotein particle remodeling | 12/1882 | 30/18723 | 1.58e-05 | 4.56e-04 | 12 |
GO:00343672 | Liver | NAFLD | protein-containing complex remodeling | 12/1882 | 32/18723 | 3.40e-05 | 8.80e-04 | 12 |
GO:0015850 | Liver | NAFLD | organic hydroxy compound transport | 50/1882 | 284/18723 | 6.01e-05 | 1.32e-03 | 50 |
GO:00444037 | Liver | NAFLD | biological process involved in symbiotic interaction | 50/1882 | 290/18723 | 1.03e-04 | 2.04e-03 | 50 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0517114 | Liver | NAFLD | Coronavirus disease - COVID-19 | 111/1043 | 232/8465 | 1.01e-41 | 3.32e-39 | 2.67e-39 | 111 |
hsa0517115 | Liver | NAFLD | Coronavirus disease - COVID-19 | 111/1043 | 232/8465 | 1.01e-41 | 3.32e-39 | 2.67e-39 | 111 |
hsa0517122 | Liver | Cirrhotic | Coronavirus disease - COVID-19 | 136/2530 | 232/8465 | 3.28e-20 | 1.82e-18 | 1.12e-18 | 136 |
hsa0541514 | Liver | Cirrhotic | Diabetic cardiomyopathy | 108/2530 | 203/8465 | 1.99e-12 | 4.41e-11 | 2.72e-11 | 108 |
hsa0517132 | Liver | Cirrhotic | Coronavirus disease - COVID-19 | 136/2530 | 232/8465 | 3.28e-20 | 1.82e-18 | 1.12e-18 | 136 |
hsa0541515 | Liver | Cirrhotic | Diabetic cardiomyopathy | 108/2530 | 203/8465 | 1.99e-12 | 4.41e-11 | 2.72e-11 | 108 |
hsa0541522 | Liver | HCC | Diabetic cardiomyopathy | 151/4020 | 203/8465 | 2.72e-15 | 1.01e-13 | 5.63e-14 | 151 |
hsa0517142 | Liver | HCC | Coronavirus disease - COVID-19 | 167/4020 | 232/8465 | 1.50e-14 | 4.19e-13 | 2.33e-13 | 167 |
hsa049334 | Liver | HCC | AGE-RAGE signaling pathway in diabetic complications | 62/4020 | 100/8465 | 2.35e-03 | 7.95e-03 | 4.42e-03 | 62 |
hsa0541532 | Liver | HCC | Diabetic cardiomyopathy | 151/4020 | 203/8465 | 2.72e-15 | 1.01e-13 | 5.63e-14 | 151 |
hsa0517152 | Liver | HCC | Coronavirus disease - COVID-19 | 167/4020 | 232/8465 | 1.50e-14 | 4.19e-13 | 2.33e-13 | 167 |
hsa0493311 | Liver | HCC | AGE-RAGE signaling pathway in diabetic complications | 62/4020 | 100/8465 | 2.35e-03 | 7.95e-03 | 4.42e-03 | 62 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
AGT | AGTR1 | AGT_AGTR1B | AGT | Esophagus | ESCC |
AGT | AGTR1 | AGT_AGTR1B | AGT | HNSCC | ADJ |
AGT | AGTR1 | AGT_AGTR1B | AGT | Liver | Healthy |
AGT | AGTR1 | AGT_AGTR1B | AGT | Liver | Precancer |
AGT | AGTR1 | AGT_AGTR1B | AGT | THCA | Precancer |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AGTR1 | SNV | Missense_Mutation | novel | c.724N>G | p.Pro242Ala | p.P242A | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-94-A5I4-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
AGTR1 | SNV | Missense_Mutation | novel | c.173N>A | p.Arg58Lys | p.R58K | protein_coding | tolerated(0.69) | benign(0.22) | TCGA-LA-A446-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
AGTR1 | SNV | Missense_Mutation | c.855C>G | p.Phe285Leu | p.F285L | protein_coding | tolerated(0.58) | benign(0.401) | TCGA-NC-A5HG-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | CR | ||
AGTR1 | SNV | Missense_Mutation | novel | c.226N>A | p.Val76Met | p.V76M | protein_coding | deleterious(0.02) | benign(0.049) | TCGA-NC-A5HH-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
AGTR1 | deletion | Frame_Shift_Del | c.941delN | p.Ile314MetfsTer12 | p.I314Mfs*12 | protein_coding | TCGA-91-6848-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | CR | ||||
AGTR1 | deletion | Frame_Shift_Del | novel | c.1185delA | p.Ter395CysfsTer8 | p.*395Cfs*8 | protein_coding | TCGA-68-7756-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | SD | |||
AGTR1 | SNV | Missense_Mutation | novel | c.965N>A | p.Thr322Asn | p.T322N | protein_coding | tolerated(0.1) | probably_damaging(0.995) | TCGA-BA-A6DA-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
AGTR1 | SNV | Missense_Mutation | novel | c.834G>A | p.Met278Ile | p.M278I | protein_coding | tolerated(0.73) | benign(0.003) | TCGA-CV-5432-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
AGTR1 | SNV | Missense_Mutation | novel | c.622N>A | p.Glu208Lys | p.E208K | protein_coding | tolerated(0.62) | benign(0.085) | TCGA-CV-6936-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
AGTR1 | SNV | Missense_Mutation | rs778954862 | c.1107G>A | p.Met369Ile | p.M369I | protein_coding | tolerated(0.16) | benign(0.007) | TCGA-CV-7089-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
185 | AGTR1 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | TASOSARTAN | TASOSARTAN | ||
185 | AGTR1 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | antagonist | 178103498 | ||
185 | AGTR1 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | atorvastatin | ATORVASTATIN | ||
185 | AGTR1 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | CSA | CYCLOSPORINE | 17477024 | |
185 | AGTR1 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | Losartan | LOSARTAN | ||
185 | AGTR1 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | DEXAMETHASONE | DEXAMETHASONE | 16482568 | |
185 | AGTR1 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | antagonist | CHEMBL2103795 | AZILSARTAN KAMEDOXOMIL | |
185 | AGTR1 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | antagonist | 178103487 | ||
185 | AGTR1 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | antagonist | 178103483 | AZILSARTAN | |
185 | AGTR1 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | ANTISENSE C-FOS | 12215476 |
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