![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: AGGF1 |
Gene summary for AGGF1 |
![]() |
Gene information | Species | Human | Gene symbol | AGGF1 | Gene ID | 55109 |
Gene name | angiogenic factor with G-patch and FHA domains 1 | |
Gene Alias | GPATC7 | |
Cytomap | 5q13.3 | |
Gene Type | protein-coding | GO ID | GO:0001525 | UniProtAcc | Q8N302 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55109 | AGGF1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.31e-04 | 2.09e-01 | -0.1808 |
55109 | AGGF1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 5.94e-03 | 2.03e-01 | -0.0811 |
55109 | AGGF1 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.92e-14 | 4.30e-01 | -0.1088 |
55109 | AGGF1 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.49e-21 | 4.17e-01 | -0.1954 |
55109 | AGGF1 | HTA11_411_2000001011 | Human | Colorectum | SER | 5.67e-08 | 5.32e-01 | -0.2602 |
55109 | AGGF1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 7.92e-03 | 1.97e-01 | -0.1207 |
55109 | AGGF1 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.39e-02 | 2.12e-01 | -0.1526 |
55109 | AGGF1 | HTA11_696_2000001011 | Human | Colorectum | AD | 8.10e-07 | 2.30e-01 | -0.1464 |
55109 | AGGF1 | HTA11_866_2000001011 | Human | Colorectum | AD | 5.57e-05 | 1.95e-01 | -0.1001 |
55109 | AGGF1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.16e-10 | 2.80e-01 | -0.059 |
55109 | AGGF1 | HTA11_546_2000001011 | Human | Colorectum | AD | 3.37e-05 | 2.98e-01 | -0.0842 |
55109 | AGGF1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.02e-02 | 1.37e-01 | 0.096 |
55109 | AGGF1 | HTA11_4255_2000001011 | Human | Colorectum | SER | 1.95e-02 | 3.30e-01 | 0.0446 |
55109 | AGGF1 | HTA11_7663_2000001011 | Human | Colorectum | SER | 7.98e-05 | 3.29e-01 | 0.0131 |
55109 | AGGF1 | HTA11_10623_2000001011 | Human | Colorectum | AD | 4.64e-04 | 2.57e-01 | -0.0177 |
55109 | AGGF1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 4.19e-02 | 1.49e-01 | 0.0338 |
55109 | AGGF1 | HTA11_6818_2000001011 | Human | Colorectum | AD | 1.95e-02 | 2.68e-01 | 0.0112 |
55109 | AGGF1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 4.50e-05 | 2.25e-01 | 0.0588 |
55109 | AGGF1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 5.65e-15 | 3.75e-01 | 0.294 |
55109 | AGGF1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 8.23e-09 | 3.03e-01 | 0.281 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0050673 | Colorectum | AD | epithelial cell proliferation | 119/3918 | 437/18723 | 8.75e-04 | 8.51e-03 | 119 |
GO:00506731 | Colorectum | MSS | epithelial cell proliferation | 108/3467 | 437/18723 | 6.76e-04 | 7.30e-03 | 108 |
GO:0050678 | Colorectum | MSS | regulation of epithelial cell proliferation | 90/3467 | 381/18723 | 6.92e-03 | 4.45e-02 | 90 |
GO:005067318 | Esophagus | ESCC | epithelial cell proliferation | 238/8552 | 437/18723 | 1.19e-04 | 8.20e-04 | 238 |
GO:005067817 | Esophagus | ESCC | regulation of epithelial cell proliferation | 206/8552 | 381/18723 | 5.51e-04 | 3.02e-03 | 206 |
GO:005067310 | Oral cavity | OSCC | epithelial cell proliferation | 212/7305 | 437/18723 | 2.82e-05 | 2.61e-04 | 212 |
GO:005067810 | Oral cavity | OSCC | regulation of epithelial cell proliferation | 180/7305 | 381/18723 | 5.88e-04 | 3.35e-03 | 180 |
GO:005067324 | Skin | cSCC | epithelial cell proliferation | 144/4864 | 437/18723 | 6.07e-04 | 4.38e-03 | 144 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AGGF1 | SNV | Missense_Mutation | c.1819N>C | p.Asp607His | p.D607H | Q8N302 | protein_coding | deleterious(0) | probably_damaging(0.963) | TCGA-55-A490-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | SD | |
AGGF1 | SNV | Missense_Mutation | novel | c.107N>C | p.Leu36Pro | p.L36P | Q8N302 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-95-7567-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
AGGF1 | SNV | Missense_Mutation | novel | c.416N>G | p.Ser139Cys | p.S139C | Q8N302 | protein_coding | deleterious(0.05) | benign(0.003) | TCGA-22-5479-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | SD |
AGGF1 | SNV | Missense_Mutation | novel | c.152A>G | p.His51Arg | p.H51R | Q8N302 | protein_coding | tolerated(0.49) | benign(0.015) | TCGA-56-8309-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
AGGF1 | SNV | Missense_Mutation | rs144241087 | c.1862A>G | p.Asn621Ser | p.N621S | Q8N302 | protein_coding | deleterious(0) | possibly_damaging(0.766) | TCGA-58-A46N-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
AGGF1 | SNV | Missense_Mutation | novel | c.1180N>A | p.Ala394Thr | p.A394T | Q8N302 | protein_coding | tolerated(0.12) | benign(0.026) | TCGA-68-7755-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unspecific | SD | |
AGGF1 | SNV | Missense_Mutation | rs372581169 | c.50N>T | p.Ser17Phe | p.S17F | Q8N302 | protein_coding | tolerated_low_confidence(0.22) | probably_damaging(0.979) | TCGA-85-A50M-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
AGGF1 | SNV | Missense_Mutation | rs762216752 | c.238C>T | p.Arg80Cys | p.R80C | Q8N302 | protein_coding | tolerated(0.06) | benign(0) | TCGA-NC-A5HQ-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | CR |
AGGF1 | SNV | Missense_Mutation | novel | c.29G>T | p.Arg10Leu | p.R10L | Q8N302 | protein_coding | tolerated_low_confidence(0.21) | benign(0) | TCGA-O2-A52S-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
AGGF1 | SNV | Missense_Mutation | novel | c.1114G>C | p.Glu372Gln | p.E372Q | Q8N302 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-CQ-7063-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
Page: 1 2 3 4 5 6 7 8 9 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |