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Gene: ADGRL2 |
Gene summary for ADGRL2 |
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Gene information | Species | Human | Gene symbol | ADGRL2 | Gene ID | 23266 |
Gene name | adhesion G protein-coupled receptor L2 | |
Gene Alias | CIRL2 | |
Cytomap | 1p31.1 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | O95490 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23266 | ADGRL2 | CCI_1 | Human | Cervix | CC | 9.96e-10 | 1.76e+00 | 0.528 |
23266 | ADGRL2 | CCI_2 | Human | Cervix | CC | 4.34e-02 | 6.38e-01 | 0.5249 |
23266 | ADGRL2 | CCI_3 | Human | Cervix | CC | 1.43e-09 | 7.74e-01 | 0.516 |
23266 | ADGRL2 | AEH-subject1 | Human | Endometrium | AEH | 3.79e-23 | 5.75e-01 | -0.3059 |
23266 | ADGRL2 | AEH-subject2 | Human | Endometrium | AEH | 4.46e-10 | 4.29e-01 | -0.2525 |
23266 | ADGRL2 | AEH-subject3 | Human | Endometrium | AEH | 2.43e-15 | 4.70e-01 | -0.2576 |
23266 | ADGRL2 | AEH-subject4 | Human | Endometrium | AEH | 1.74e-15 | 5.51e-01 | -0.2657 |
23266 | ADGRL2 | AEH-subject5 | Human | Endometrium | AEH | 2.97e-11 | 3.91e-01 | -0.2953 |
23266 | ADGRL2 | EEC-subject1 | Human | Endometrium | EEC | 5.17e-06 | 2.78e-01 | -0.2682 |
23266 | ADGRL2 | EEC-subject2 | Human | Endometrium | EEC | 3.17e-07 | 3.10e-01 | -0.2607 |
23266 | ADGRL2 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 3.55e-03 | 1.98e-01 | -0.1883 |
23266 | ADGRL2 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 1.27e-02 | -6.06e-02 | -0.1934 |
23266 | ADGRL2 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 4.26e-03 | 4.94e-02 | -0.1917 |
23266 | ADGRL2 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 6.75e-03 | 9.11e-02 | -0.1916 |
23266 | ADGRL2 | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 7.50e-10 | 3.75e-01 | -0.1269 |
23266 | ADGRL2 | P2T-E | Human | Esophagus | ESCC | 3.86e-20 | 2.90e-01 | 0.1177 |
23266 | ADGRL2 | P5T-E | Human | Esophagus | ESCC | 1.10e-02 | 5.29e-02 | 0.1327 |
23266 | ADGRL2 | P8T-E | Human | Esophagus | ESCC | 3.52e-05 | 6.33e-02 | 0.0889 |
23266 | ADGRL2 | P10T-E | Human | Esophagus | ESCC | 4.01e-09 | 1.77e-01 | 0.116 |
23266 | ADGRL2 | P22T-E | Human | Esophagus | ESCC | 3.72e-02 | -8.69e-03 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00343298 | Cervix | CC | cell junction assembly | 88/2311 | 420/18723 | 3.42e-07 | 1.38e-05 | 88 |
GO:19018886 | Cervix | CC | regulation of cell junction assembly | 42/2311 | 204/18723 | 5.50e-04 | 5.29e-03 | 42 |
GO:00519603 | Cervix | CC | regulation of nervous system development | 77/2311 | 443/18723 | 1.13e-03 | 9.30e-03 | 77 |
GO:00519622 | Cervix | CC | positive regulation of nervous system development | 48/2311 | 272/18723 | 6.60e-03 | 3.65e-02 | 48 |
GO:00343299 | Endometrium | AEH | cell junction assembly | 78/2100 | 420/18723 | 4.80e-06 | 1.24e-04 | 78 |
GO:19018887 | Endometrium | AEH | regulation of cell junction assembly | 39/2100 | 204/18723 | 5.94e-04 | 5.86e-03 | 39 |
GO:00508086 | Endometrium | AEH | synapse organization | 67/2100 | 426/18723 | 2.67e-03 | 1.94e-02 | 67 |
GO:003432914 | Endometrium | EEC | cell junction assembly | 79/2168 | 420/18723 | 8.37e-06 | 1.85e-04 | 79 |
GO:190188812 | Endometrium | EEC | regulation of cell junction assembly | 37/2168 | 204/18723 | 3.70e-03 | 2.48e-02 | 37 |
GO:005080812 | Endometrium | EEC | synapse organization | 68/2168 | 426/18723 | 3.73e-03 | 2.49e-02 | 68 |
GO:003432918 | Esophagus | ESCC | cell junction assembly | 227/8552 | 420/18723 | 3.06e-04 | 1.83e-03 | 227 |
GO:00519606 | Esophagus | ESCC | regulation of nervous system development | 237/8552 | 443/18723 | 5.02e-04 | 2.78e-03 | 237 |
GO:00519625 | Esophagus | ESCC | positive regulation of nervous system development | 149/8552 | 272/18723 | 1.50e-03 | 7.06e-03 | 149 |
GO:190188810 | Esophagus | ESCC | regulation of cell junction assembly | 109/8552 | 204/18723 | 1.53e-02 | 4.96e-02 | 109 |
GO:00343296 | Liver | NAFLD | cell junction assembly | 66/1882 | 420/18723 | 1.64e-04 | 3.00e-03 | 66 |
GO:19018884 | Liver | NAFLD | regulation of cell junction assembly | 36/1882 | 204/18723 | 5.82e-04 | 7.77e-03 | 36 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ADGRL2 | SNV | Missense_Mutation | novel | c.314T>C | p.Val105Ala | p.V105A | O95490 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ADGRL2 | insertion | Frame_Shift_Ins | novel | c.3807_3808insA | p.Asn1270LysfsTer37 | p.N1270Kfs*37 | O95490 | protein_coding | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
ADGRL2 | deletion | Frame_Shift_Del | novel | c.1787delN | p.Lys597AsnfsTer21 | p.K597Nfs*21 | O95490 | protein_coding | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
ADGRL2 | insertion | Frame_Shift_Ins | novel | c.2320_2321insC | p.Leu775ProfsTer5 | p.L775Pfs*5 | O95490 | protein_coding | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ADGRL2 | insertion | Frame_Shift_Ins | novel | c.725_726insCTATTTT | p.Glu242AspfsTer7 | p.E242Dfs*7 | O95490 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ADGRL2 | insertion | Frame_Shift_Ins | novel | c.2615dupT | p.Arg873ProfsTer6 | p.R873Pfs*6 | O95490 | protein_coding | TCGA-QG-A5YW-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | capecitabine | CR | ||
ADGRL2 | SNV | Missense_Mutation | novel | c.2656N>T | p.Leu886Phe | p.L886F | O95490 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ADGRL2 | SNV | Missense_Mutation | rs780914901 | c.184N>A | p.Ala62Thr | p.A62T | O95490 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ADGRL2 | SNV | Missense_Mutation | novel | c.742N>A | p.Ala248Thr | p.A248T | O95490 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ADGRL2 | SNV | Missense_Mutation | novel | c.1364N>G | p.Ile455Ser | p.I455S | O95490 | protein_coding | tolerated(0.8) | probably_damaging(0.987) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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