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Gene: ADCY9 |
Gene summary for ADCY9 |
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Gene information | Species | Human | Gene symbol | ADCY9 | Gene ID | 115 |
Gene name | adenylate cyclase 9 | |
Gene Alias | AC9 | |
Cytomap | 16p13.3 | |
Gene Type | protein-coding | GO ID | GO:0001701 | UniProtAcc | O60503 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
115 | ADCY9 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.33e-09 | -4.38e-01 | 0.0155 |
115 | ADCY9 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.73e-04 | -3.54e-01 | 0.096 |
115 | ADCY9 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.92e-06 | -3.58e-01 | 0.0674 |
115 | ADCY9 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 6.31e-15 | -3.94e-01 | 0.294 |
115 | ADCY9 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.15e-16 | -5.07e-01 | 0.3005 |
115 | ADCY9 | F007 | Human | Colorectum | FAP | 2.51e-08 | -4.68e-01 | 0.1176 |
115 | ADCY9 | A002-C-010 | Human | Colorectum | FAP | 3.10e-10 | -4.01e-01 | 0.242 |
115 | ADCY9 | A001-C-207 | Human | Colorectum | FAP | 3.07e-10 | -5.19e-01 | 0.1278 |
115 | ADCY9 | A015-C-203 | Human | Colorectum | FAP | 1.49e-27 | -5.04e-01 | -0.1294 |
115 | ADCY9 | A015-C-204 | Human | Colorectum | FAP | 4.11e-11 | -4.39e-01 | -0.0228 |
115 | ADCY9 | A014-C-040 | Human | Colorectum | FAP | 3.33e-04 | -4.93e-01 | -0.1184 |
115 | ADCY9 | A002-C-201 | Human | Colorectum | FAP | 2.89e-21 | -5.59e-01 | 0.0324 |
115 | ADCY9 | A002-C-203 | Human | Colorectum | FAP | 4.39e-15 | -4.83e-01 | 0.2786 |
115 | ADCY9 | A001-C-119 | Human | Colorectum | FAP | 1.19e-05 | -2.78e-01 | -0.1557 |
115 | ADCY9 | A001-C-108 | Human | Colorectum | FAP | 1.13e-23 | -4.45e-01 | -0.0272 |
115 | ADCY9 | A002-C-205 | Human | Colorectum | FAP | 2.38e-19 | -4.52e-01 | -0.1236 |
115 | ADCY9 | A001-C-104 | Human | Colorectum | FAP | 7.21e-09 | -4.06e-01 | 0.0184 |
115 | ADCY9 | A015-C-005 | Human | Colorectum | FAP | 1.71e-04 | -2.59e-01 | -0.0336 |
115 | ADCY9 | A015-C-006 | Human | Colorectum | FAP | 1.15e-10 | -3.91e-01 | -0.0994 |
115 | ADCY9 | A015-C-106 | Human | Colorectum | FAP | 7.48e-15 | -3.99e-01 | -0.0511 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0009150 | Colorectum | AD | purine ribonucleotide metabolic process | 142/3918 | 368/18723 | 4.29e-15 | 1.17e-12 | 142 |
GO:0006163 | Colorectum | AD | purine nucleotide metabolic process | 149/3918 | 396/18723 | 1.08e-14 | 2.80e-12 | 149 |
GO:0072521 | Colorectum | AD | purine-containing compound metabolic process | 153/3918 | 416/18723 | 4.34e-14 | 1.01e-11 | 153 |
GO:0009259 | Colorectum | AD | ribonucleotide metabolic process | 144/3918 | 385/18723 | 5.25e-14 | 1.13e-11 | 144 |
GO:0019693 | Colorectum | AD | ribose phosphate metabolic process | 145/3918 | 396/18723 | 3.01e-13 | 5.71e-11 | 145 |
GO:0009117 | Colorectum | AD | nucleotide metabolic process | 168/3918 | 489/18723 | 2.20e-12 | 3.36e-10 | 168 |
GO:0006753 | Colorectum | AD | nucleoside phosphate metabolic process | 169/3918 | 497/18723 | 4.99e-12 | 6.98e-10 | 169 |
GO:0009152 | Colorectum | AD | purine ribonucleotide biosynthetic process | 64/3918 | 169/18723 | 3.09e-07 | 1.22e-05 | 64 |
GO:0009260 | Colorectum | AD | ribonucleotide biosynthetic process | 66/3918 | 182/18723 | 1.25e-06 | 4.02e-05 | 66 |
GO:0046390 | Colorectum | AD | ribose phosphate biosynthetic process | 67/3918 | 190/18723 | 3.21e-06 | 9.05e-05 | 67 |
GO:0006164 | Colorectum | AD | purine nucleotide biosynthetic process | 66/3918 | 191/18723 | 8.22e-06 | 1.97e-04 | 66 |
GO:0072522 | Colorectum | AD | purine-containing compound biosynthetic process | 68/3918 | 200/18723 | 1.12e-05 | 2.55e-04 | 68 |
GO:0001701 | Colorectum | AD | in utero embryonic development | 110/3918 | 367/18723 | 2.36e-05 | 4.62e-04 | 110 |
GO:1901293 | Colorectum | AD | nucleoside phosphate biosynthetic process | 80/3918 | 256/18723 | 6.31e-05 | 1.05e-03 | 80 |
GO:0009165 | Colorectum | AD | nucleotide biosynthetic process | 79/3918 | 254/18723 | 8.33e-05 | 1.30e-03 | 79 |
GO:00061632 | Colorectum | MSS | purine nucleotide metabolic process | 128/3467 | 396/18723 | 2.04e-11 | 3.02e-09 | 128 |
GO:00091502 | Colorectum | MSS | purine ribonucleotide metabolic process | 121/3467 | 368/18723 | 2.08e-11 | 3.02e-09 | 121 |
GO:00725212 | Colorectum | MSS | purine-containing compound metabolic process | 132/3467 | 416/18723 | 4.13e-11 | 4.86e-09 | 132 |
GO:00092592 | Colorectum | MSS | ribonucleotide metabolic process | 123/3467 | 385/18723 | 1.17e-10 | 1.20e-08 | 123 |
GO:00196932 | Colorectum | MSS | ribose phosphate metabolic process | 124/3467 | 396/18723 | 4.11e-10 | 3.49e-08 | 124 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04714 | Colorectum | AD | Thermogenesis | 120/2092 | 232/8465 | 2.76e-19 | 1.16e-17 | 7.37e-18 | 120 |
hsa05110 | Colorectum | AD | Vibrio cholerae infection | 29/2092 | 50/8465 | 5.10e-07 | 7.12e-06 | 4.54e-06 | 29 |
hsa04723 | Colorectum | AD | Retrograde endocannabinoid signaling | 59/2092 | 148/8465 | 2.94e-05 | 2.73e-04 | 1.74e-04 | 59 |
hsa04213 | Colorectum | AD | Longevity regulating pathway - multiple species | 27/2092 | 62/8465 | 8.72e-04 | 5.96e-03 | 3.80e-03 | 27 |
hsa04015 | Colorectum | AD | Rap1 signaling pathway | 71/2092 | 210/8465 | 1.72e-03 | 9.68e-03 | 6.18e-03 | 71 |
hsa05163 | Colorectum | AD | Human cytomegalovirus infection | 75/2092 | 225/8465 | 2.00e-03 | 1.10e-02 | 7.01e-03 | 75 |
hsa04912 | Colorectum | AD | GnRH signaling pathway | 35/2092 | 93/8465 | 3.69e-03 | 1.90e-02 | 1.21e-02 | 35 |
hsa05166 | Colorectum | AD | Human T-cell leukemia virus 1 infection | 72/2092 | 222/8465 | 5.24e-03 | 2.44e-02 | 1.55e-02 | 72 |
hsa04962 | Colorectum | AD | Vasopressin-regulated water reabsorption | 19/2092 | 44/8465 | 5.48e-03 | 2.48e-02 | 1.58e-02 | 19 |
hsa04211 | Colorectum | AD | Longevity regulating pathway | 33/2092 | 89/8465 | 6.15e-03 | 2.68e-02 | 1.71e-02 | 33 |
hsa04971 | Colorectum | AD | Gastric acid secretion | 29/2092 | 76/8465 | 6.25e-03 | 2.68e-02 | 1.71e-02 | 29 |
hsa04928 | Colorectum | AD | Parathyroid hormone synthesis, secretion and action | 38/2092 | 106/8465 | 6.60e-03 | 2.77e-02 | 1.76e-02 | 38 |
hsa04972 | Colorectum | AD | Pancreatic secretion | 36/2092 | 102/8465 | 1.06e-02 | 3.98e-02 | 2.54e-02 | 36 |
hsa047141 | Colorectum | AD | Thermogenesis | 120/2092 | 232/8465 | 2.76e-19 | 1.16e-17 | 7.37e-18 | 120 |
hsa051101 | Colorectum | AD | Vibrio cholerae infection | 29/2092 | 50/8465 | 5.10e-07 | 7.12e-06 | 4.54e-06 | 29 |
hsa047231 | Colorectum | AD | Retrograde endocannabinoid signaling | 59/2092 | 148/8465 | 2.94e-05 | 2.73e-04 | 1.74e-04 | 59 |
hsa042131 | Colorectum | AD | Longevity regulating pathway - multiple species | 27/2092 | 62/8465 | 8.72e-04 | 5.96e-03 | 3.80e-03 | 27 |
hsa040151 | Colorectum | AD | Rap1 signaling pathway | 71/2092 | 210/8465 | 1.72e-03 | 9.68e-03 | 6.18e-03 | 71 |
hsa051631 | Colorectum | AD | Human cytomegalovirus infection | 75/2092 | 225/8465 | 2.00e-03 | 1.10e-02 | 7.01e-03 | 75 |
hsa049121 | Colorectum | AD | GnRH signaling pathway | 35/2092 | 93/8465 | 3.69e-03 | 1.90e-02 | 1.21e-02 | 35 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ADCY9 | SNV | Missense_Mutation | c.1988N>T | p.Lys663Met | p.K663M | O60503 | protein_coding | deleterious(0.01) | benign(0.339) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD | |
ADCY9 | SNV | Missense_Mutation | rs375674603 | c.2542N>A | p.Val848Ile | p.V848I | O60503 | protein_coding | deleterious(0.03) | benign(0.04) | TCGA-QG-A5YW-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | capecitabine | CR |
ADCY9 | SNV | Missense_Mutation | novel | c.952N>T | p.Met318Leu | p.M318L | O60503 | protein_coding | tolerated(0.29) | benign(0.125) | TCGA-AG-3881-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ADCY9 | SNV | Missense_Mutation | c.685N>A | p.Glu229Lys | p.E229K | O60503 | protein_coding | deleterious(0.01) | benign(0.144) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ADCY9 | SNV | Missense_Mutation | c.3462N>A | p.Asn1154Lys | p.N1154K | O60503 | protein_coding | tolerated(1) | benign(0.007) | TCGA-DY-A1DD-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
ADCY9 | SNV | Missense_Mutation | c.4027N>A | p.Glu1343Lys | p.E1343K | O60503 | protein_coding | deleterious_low_confidence(0) | benign(0.408) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD | |
ADCY9 | SNV | Missense_Mutation | rs374081146 | c.4003N>A | p.Glu1335Lys | p.E1335K | O60503 | protein_coding | tolerated_low_confidence(0.33) | benign(0.048) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ADCY9 | deletion | Frame_Shift_Del | c.444delN | p.Ala149ArgfsTer38 | p.A149Rfs*38 | O60503 | protein_coding | TCGA-QG-A5Z2-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |||
ADCY9 | SNV | Missense_Mutation | rs770270080 | c.2594N>A | p.Arg865His | p.R865H | O60503 | protein_coding | deleterious(0.04) | probably_damaging(0.997) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ADCY9 | SNV | Missense_Mutation | rs545959256 | c.2905N>T | p.Arg969Cys | p.R969C | O60503 | protein_coding | tolerated(0.06) | benign(0.083) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
115 | ADCY9 | KINASE, ENZYME, DRUGGABLE GENOME | NSC-270718 | CHEMBL401844 | 18630896 | |
115 | ADCY9 | KINASE, ENZYME, DRUGGABLE GENOME | dalcetrapib | DALCETRAPIB | 25583994 |
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