![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ACTG2 |
Gene summary for ACTG2 |
![]() |
Gene information | Species | Human | Gene symbol | ACTG2 | Gene ID | 72 |
Gene name | actin gamma 2, smooth muscle | |
Gene Alias | ACT | |
Cytomap | 2p13.1 | |
Gene Type | protein-coding | GO ID | GO:0007275 | UniProtAcc | P63267 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
72 | ACTG2 | P2T-E | Human | Esophagus | ESCC | 3.38e-10 | 4.24e-01 | 0.1177 |
72 | ACTG2 | P4T-E | Human | Esophagus | ESCC | 1.53e-04 | 5.70e-01 | 0.1323 |
72 | ACTG2 | P16T-E | Human | Esophagus | ESCC | 1.77e-104 | 3.33e+00 | 0.1153 |
72 | ACTG2 | P19T-E | Human | Esophagus | ESCC | 4.25e-02 | 2.23e+00 | 0.1662 |
72 | ACTG2 | P24T-E | Human | Esophagus | ESCC | 3.75e-03 | 6.74e-01 | 0.1287 |
72 | ACTG2 | P32T-E | Human | Esophagus | ESCC | 7.90e-03 | 5.29e-01 | 0.1666 |
72 | ACTG2 | P44T-E | Human | Esophagus | ESCC | 1.94e-02 | 1.30e+00 | 0.1096 |
72 | ACTG2 | P56T-E | Human | Esophagus | ESCC | 4.16e-09 | 1.90e+00 | 0.1613 |
72 | ACTG2 | P76T-E | Human | Esophagus | ESCC | 5.17e-27 | 1.59e+00 | 0.1207 |
72 | ACTG2 | P79T-E | Human | Esophagus | ESCC | 8.40e-04 | 2.13e-01 | 0.1154 |
72 | ACTG2 | P130T-E | Human | Esophagus | ESCC | 1.92e-37 | 2.05e+00 | 0.1676 |
72 | ACTG2 | ATC11 | Human | Thyroid | ATC | 3.71e-05 | 2.40e+00 | 0.3386 |
72 | ACTG2 | ATC13 | Human | Thyroid | ATC | 5.88e-09 | 4.69e-01 | 0.34 |
72 | ACTG2 | ATC3 | Human | Thyroid | ATC | 3.69e-12 | 2.27e+00 | 0.338 |
72 | ACTG2 | ATC5 | Human | Thyroid | ATC | 1.28e-08 | 5.44e-01 | 0.34 |
Page: 1 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00604856 | Esophagus | ESCC | mesenchyme development | 156/8552 | 291/18723 | 3.76e-03 | 1.53e-02 | 156 |
GO:009013020 | Esophagus | ESCC | tissue migration | 190/8552 | 365/18723 | 7.91e-03 | 2.82e-02 | 190 |
GO:009013031 | Thyroid | ATC | tissue migration | 171/6293 | 365/18723 | 8.55e-08 | 1.47e-06 | 171 |
GO:006048521 | Thyroid | ATC | mesenchyme development | 136/6293 | 291/18723 | 2.04e-06 | 2.43e-05 | 136 |
GO:0072132 | Thyroid | ATC | mesenchyme morphogenesis | 30/6293 | 52/18723 | 3.08e-04 | 1.94e-03 | 30 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ACTG2 | SNV | Missense_Mutation | novel | c.724N>C | p.Glu242Gln | p.E242Q | P63267 | protein_coding | deleterious_low_confidence(0.02) | possibly_damaging(0.749) | TCGA-QK-A6II-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
ACTG2 | SNV | Missense_Mutation | c.613G>T | p.Ala205Ser | p.A205S | P63267 | protein_coding | deleterious_low_confidence(0.04) | possibly_damaging(0.517) | TCGA-BR-4362-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ACTG2 | SNV | Missense_Mutation | c.907G>A | p.Gly303Ser | p.G303S | P63267 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.863) | TCGA-BR-6455-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | etoposide phosphate | PD | |
ACTG2 | SNV | Missense_Mutation | c.183C>A | p.Ser61Arg | p.S61R | P63267 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.875) | TCGA-BR-8690-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR | |
ACTG2 | SNV | Missense_Mutation | c.887N>G | p.Ala296Gly | p.A296G | P63267 | protein_coding | tolerated_low_confidence(0.55) | benign(0) | TCGA-CG-4306-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
ACTG2 | SNV | Missense_Mutation | c.681N>C | p.Glu227Asp | p.E227D | P63267 | protein_coding | deleterious_low_confidence(0.03) | benign(0.178) | TCGA-CG-4437-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ACTG2 | SNV | Missense_Mutation | rs199696794 | c.817N>A | p.Ala273Thr | p.A273T | P63267 | protein_coding | tolerated_low_confidence(0.28) | benign(0.07) | TCGA-HU-A4G8-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD |
ACTG2 | SNV | Missense_Mutation | novel | c.22G>A | p.Ala8Thr | p.A8T | P63267 | protein_coding | tolerated_low_confidence(0.06) | possibly_damaging(0.887) | TCGA-R5-A7O7-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
ACTG2 | SNV | Missense_Mutation | novel | c.545N>T | p.Ala182Val | p.A182V | P63267 | protein_coding | deleterious_low_confidence(0) | probably_damaging(1) | TCGA-VQ-A91D-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
ACTG2 | insertion | Frame_Shift_Ins | novel | c.584_585insAG | p.Gly198GlufsTer6 | p.G198Efs*6 | P63267 | protein_coding | TCGA-MX-A5UJ-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |