![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ABCG1 |
Gene summary for ABCG1 |
![]() |
Gene information | Species | Human | Gene symbol | ABCG1 | Gene ID | 9619 |
Gene name | ATP binding cassette subfamily G member 1 | |
Gene Alias | ABC8 | |
Cytomap | 21q22.3 | |
Gene Type | protein-coding | GO ID | GO:0001678 | UniProtAcc | P45844 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9619 | ABCG1 | LZE20T | Human | Esophagus | ESCC | 1.08e-04 | 1.90e-01 | 0.0662 |
9619 | ABCG1 | LZE24T | Human | Esophagus | ESCC | 3.43e-14 | 3.80e-01 | 0.0596 |
9619 | ABCG1 | LZE21T | Human | Esophagus | ESCC | 3.96e-05 | 2.71e-01 | 0.0655 |
9619 | ABCG1 | P1T-E | Human | Esophagus | ESCC | 1.01e-08 | 5.12e-01 | 0.0875 |
9619 | ABCG1 | P2T-E | Human | Esophagus | ESCC | 7.88e-07 | 1.63e-01 | 0.1177 |
9619 | ABCG1 | P5T-E | Human | Esophagus | ESCC | 4.86e-19 | 2.82e-01 | 0.1327 |
9619 | ABCG1 | P8T-E | Human | Esophagus | ESCC | 8.58e-14 | 2.56e-01 | 0.0889 |
9619 | ABCG1 | P9T-E | Human | Esophagus | ESCC | 1.05e-08 | 1.67e-01 | 0.1131 |
9619 | ABCG1 | P10T-E | Human | Esophagus | ESCC | 4.03e-15 | 3.61e-01 | 0.116 |
9619 | ABCG1 | P11T-E | Human | Esophagus | ESCC | 2.17e-06 | 3.60e-01 | 0.1426 |
9619 | ABCG1 | P12T-E | Human | Esophagus | ESCC | 9.15e-23 | 5.08e-01 | 0.1122 |
9619 | ABCG1 | P15T-E | Human | Esophagus | ESCC | 1.19e-20 | 4.57e-01 | 0.1149 |
9619 | ABCG1 | P16T-E | Human | Esophagus | ESCC | 2.13e-09 | 2.81e-01 | 0.1153 |
9619 | ABCG1 | P21T-E | Human | Esophagus | ESCC | 4.52e-21 | 3.86e-01 | 0.1617 |
9619 | ABCG1 | P23T-E | Human | Esophagus | ESCC | 2.09e-22 | 4.74e-01 | 0.108 |
9619 | ABCG1 | P24T-E | Human | Esophagus | ESCC | 3.71e-02 | 5.64e-02 | 0.1287 |
9619 | ABCG1 | P26T-E | Human | Esophagus | ESCC | 4.11e-45 | 9.04e-01 | 0.1276 |
9619 | ABCG1 | P27T-E | Human | Esophagus | ESCC | 7.83e-15 | 2.14e-01 | 0.1055 |
9619 | ABCG1 | P28T-E | Human | Esophagus | ESCC | 1.96e-18 | 4.39e-01 | 0.1149 |
9619 | ABCG1 | P30T-E | Human | Esophagus | ESCC | 7.38e-13 | 6.12e-01 | 0.137 |
Page: 1 2 3 4 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001605014 | Esophagus | ESCC | vesicle organization | 211/8552 | 300/18723 | 2.85e-18 | 2.87e-16 | 211 |
GO:1904951111 | Esophagus | ESCC | positive regulation of establishment of protein localization | 216/8552 | 319/18723 | 1.01e-15 | 6.86e-14 | 216 |
GO:0034250111 | Esophagus | ESCC | positive regulation of cellular amide metabolic process | 123/8552 | 162/18723 | 3.32e-15 | 1.93e-13 | 123 |
GO:0051222111 | Esophagus | ESCC | positive regulation of protein transport | 204/8552 | 303/18723 | 1.56e-14 | 8.38e-13 | 204 |
GO:0051235110 | Esophagus | ESCC | maintenance of location | 200/8552 | 327/18723 | 1.01e-08 | 2.02e-07 | 200 |
GO:00060668 | Esophagus | ESCC | alcohol metabolic process | 202/8552 | 353/18723 | 7.32e-06 | 7.26e-05 | 202 |
GO:00161263 | Esophagus | ESCC | sterol biosynthetic process | 46/8552 | 64/18723 | 1.91e-05 | 1.67e-04 | 46 |
GO:00066953 | Esophagus | ESCC | cholesterol biosynthetic process | 41/8552 | 57/18723 | 5.25e-05 | 4.06e-04 | 41 |
GO:19026533 | Esophagus | ESCC | secondary alcohol biosynthetic process | 41/8552 | 57/18723 | 5.25e-05 | 4.06e-04 | 41 |
GO:00199155 | Esophagus | ESCC | lipid storage | 58/8552 | 87/18723 | 6.15e-05 | 4.72e-04 | 58 |
GO:00620129 | Esophagus | ESCC | regulation of small molecule metabolic process | 184/8552 | 334/18723 | 3.11e-04 | 1.85e-03 | 184 |
GO:19026524 | Esophagus | ESCC | secondary alcohol metabolic process | 87/8552 | 147/18723 | 6.58e-04 | 3.50e-03 | 87 |
GO:00461653 | Esophagus | ESCC | alcohol biosynthetic process | 83/8552 | 140/18723 | 8.04e-04 | 4.16e-03 | 83 |
GO:00108884 | Esophagus | ESCC | negative regulation of lipid storage | 18/8552 | 23/18723 | 1.50e-03 | 7.06e-03 | 18 |
GO:19019987 | Esophagus | ESCC | toxin transport | 28/8552 | 40/18723 | 1.61e-03 | 7.50e-03 | 28 |
GO:00066946 | Esophagus | ESCC | steroid biosynthetic process | 98/8552 | 173/18723 | 2.34e-03 | 1.03e-02 | 98 |
GO:00082034 | Esophagus | ESCC | cholesterol metabolic process | 79/8552 | 137/18723 | 3.11e-03 | 1.29e-02 | 79 |
GO:000930617 | Esophagus | ESCC | protein secretion | 190/8552 | 359/18723 | 3.22e-03 | 1.34e-02 | 190 |
GO:003559217 | Esophagus | ESCC | establishment of protein localization to extracellular region | 190/8552 | 360/18723 | 3.77e-03 | 1.53e-02 | 190 |
GO:00161254 | Esophagus | ESCC | sterol metabolic process | 86/8552 | 152/18723 | 4.37e-03 | 1.73e-02 | 86 |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05417211 | Esophagus | ESCC | Lipid and atherosclerosis | 143/4205 | 215/8465 | 3.30e-07 | 2.45e-06 | 1.26e-06 | 143 |
hsa05417310 | Esophagus | ESCC | Lipid and atherosclerosis | 143/4205 | 215/8465 | 3.30e-07 | 2.45e-06 | 1.26e-06 | 143 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ABCG1 | SNV | Missense_Mutation | c.1747N>G | p.Phe583Val | p.F583V | P45844 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-BR-8366-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ABCG1 | SNV | Missense_Mutation | rs756353022 | c.1046N>A | p.Cys349Tyr | p.C349Y | P45844 | protein_coding | tolerated(0.05) | possibly_damaging(0.832) | TCGA-BR-8368-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ABCG1 | SNV | Missense_Mutation | novel | c.970N>G | p.Phe324Val | p.F324V | P45844 | protein_coding | deleterious(0) | possibly_damaging(0.87) | TCGA-BR-8589-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
ABCG1 | SNV | Missense_Mutation | c.719N>C | p.Phe240Ser | p.F240S | P45844 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
ABCG1 | SNV | Missense_Mutation | c.712N>G | p.Met238Val | p.M238V | P45844 | protein_coding | deleterious(0.02) | possibly_damaging(0.506) | TCGA-BR-A4QL-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | CR | |
ABCG1 | SNV | Missense_Mutation | rs748557431 | c.1594N>A | p.Val532Met | p.V532M | P45844 | protein_coding | tolerated(0.24) | benign(0.042) | TCGA-D7-A4YY-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | SD |
ABCG1 | SNV | Missense_Mutation | novel | c.541N>C | p.Ser181Pro | p.S181P | P45844 | protein_coding | deleterious(0) | benign(0.261) | TCGA-D7-A6EY-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
ABCG1 | SNV | Missense_Mutation | novel | c.1285N>G | p.Ser429Ala | p.S429A | P45844 | protein_coding | tolerated(0.27) | probably_damaging(0.99) | TCGA-D7-A6EY-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
ABCG1 | SNV | Missense_Mutation | c.671G>A | p.Arg224His | p.R224H | P45844 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-HU-8602-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | xeloda | CR | |
ABCG1 | SNV | Missense_Mutation | c.344N>T | p.Ala115Val | p.A115V | P45844 | protein_coding | deleterious(0.01) | possibly_damaging(0.809) | TCGA-HU-A4H3-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Chemotherapy | ts-1 | PD |
Page: 1 2 3 4 5 6 7 8 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
9619 | ABCG1 | TRANSPORTER, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | leucovorin | LEUCOVORIN | 26352872 | |
9619 | ABCG1 | TRANSPORTER, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | irinotecan | IRINOTECAN | 26352872 | |
9619 | ABCG1 | TRANSPORTER, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | fluorouracil | FLUOROURACIL | 26352872 |
Page: 1 |