Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/ABCF1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/ABCF1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/ABCF1_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/ABCF1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/ABCF1_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/ABCF1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/ABCF1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ABCF1 | SNV | Missense_Mutation | novel | c.818C>T | p.Ser273Leu | p.S273L | Q8NE71 | protein_coding | tolerated(0.1) | benign(0.268) | TCGA-BB-A5HY-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
ABCF1 | SNV | Missense_Mutation | | c.856N>A | p.Val286Met | p.V286M | Q8NE71 | protein_coding | tolerated(0.06) | possibly_damaging(0.658) | TCGA-C9-A47Z-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ABCF1 | SNV | Missense_Mutation | rs534029778 | c.2183N>T | p.Arg728Leu | p.R728L | Q8NE71 | protein_coding | deleterious(0.01) | probably_damaging(0.924) | TCGA-CN-6992-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
ABCF1 | SNV | Missense_Mutation | | c.419N>C | p.Ser140Thr | p.S140T | Q8NE71 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.59) | TCGA-CV-6956-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
ABCF1 | SNV | Missense_Mutation | novel | c.1850N>T | p.Pro617Leu | p.P617L | Q8NE71 | protein_coding | deleterious(0.01) | possibly_damaging(0.573) | TCGA-D6-6516-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ABCF1 | insertion | Frame_Shift_Ins | novel | c.1130_1131insC | p.Gln378ProfsTer7 | p.Q378Pfs*7 | Q8NE71 | protein_coding | | | TCGA-CV-7097-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
ABCF1 | insertion | Frame_Shift_Ins | novel | c.344-1_344insGTATC | p.Val115GlyfsTer23 | p.V115Gfs*23 | Q8NE71 | protein_coding | | | TCGA-HD-8635-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ABCF1 | insertion | Frame_Shift_Ins | novel | c.915_915+1insCTGGAGAA | p.Lys308AsnfsTer23 | p.K308Nfs*23 | Q8NE71 | protein_coding | | | TCGA-IQ-A61E-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
ABCF1 | insertion | Frame_Shift_Ins | novel | c.1475_1475+1insCTACCTCCAGGGCTGGCGGAAGACCTTGCTGATC | p.Val504LeufsTer15 | p.V504Lfs*15 | Q8NE71 | protein_coding | | | TCGA-IQ-A61E-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
ABCF1 | SNV | Missense_Mutation | novel | c.1060N>A | p.Leu354Met | p.L354M | Q8NE71 | protein_coding | deleterious(0.01) | probably_damaging(0.989) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |