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Gene: XIRP2 |
Gene summary for XIRP2 |
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Gene information | Species | Human | Gene symbol | XIRP2 | Gene ID | 129446 |
Gene name | xin actin binding repeat containing 2 | |
Gene Alias | CMYA3 | |
Cytomap | 2q24.3 | |
Gene Type | protein-coding | GO ID | GO:0003007 | UniProtAcc | A4UGR9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
129446 | XIRP2 | HTA11_7469_2000001011 | Human | Colorectum | AD | 1.62e-18 | 1.66e+00 | -0.0124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0007015 | Colorectum | AD | actin filament organization | 167/3918 | 442/18723 | 1.65e-16 | 7.94e-14 | 167 |
GO:0045216 | Colorectum | AD | cell-cell junction organization | 80/3918 | 200/18723 | 5.57e-10 | 4.58e-08 | 80 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
XIRP2 | deletion | Frame_Shift_Del | novel | c.10079delN | p.Thr3360LysfsTer19 | p.T3360Kfs*19 | A4UGR9 | protein_coding | TCGA-33-AASB-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
XIRP2 | insertion | In_Frame_Ins | novel | c.6255_6256insGTTCTTTCTTCT | p.Ser2085_Thr2086insValLeuSerSer | p.S2085_T2086insVLSS | A4UGR9 | protein_coding | TCGA-56-8629-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR | ||
XIRP2 | SNV | Missense_Mutation | novel | c.3061N>G | p.Phe1021Val | p.F1021V | A4UGR9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BA-4075-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | carboplatin | PD |
XIRP2 | SNV | Missense_Mutation | c.8221N>A | p.Gln2741Lys | p.Q2741K | A4UGR9 | protein_coding | deleterious(0.03) | possibly_damaging(0.677) | TCGA-BA-4075-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | carboplatin | PD | |
XIRP2 | SNV | Missense_Mutation | c.1698N>T | p.Trp566Cys | p.W566C | A4UGR9 | protein_coding | deleterious(0) | benign(0.366) | TCGA-BA-6869-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
XIRP2 | SNV | Missense_Mutation | novel | c.10467A>T | p.Arg3489Ser | p.R3489S | A4UGR9 | protein_coding | tolerated(0.22) | benign(0.011) | TCGA-BA-A6DI-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
XIRP2 | SNV | Missense_Mutation | c.1203N>G | p.Phe401Leu | p.F401L | A4UGR9 | protein_coding | tolerated(1) | benign(0) | TCGA-BB-A5HU-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR | |
XIRP2 | SNV | Missense_Mutation | novel | c.712N>A | p.Phe238Ile | p.F238I | A4UGR9 | protein_coding | tolerated(0.36) | probably_damaging(0.974) | TCGA-CN-4731-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | erbitux | PD |
XIRP2 | SNV | Missense_Mutation | c.5781G>T | p.Arg1927Ser | p.R1927S | A4UGR9 | protein_coding | deleterious(0) | possibly_damaging(0.564) | TCGA-CN-4739-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD | |
XIRP2 | SNV | Missense_Mutation | novel | c.3079G>A | p.Asp1027Asn | p.D1027N | A4UGR9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CN-5369-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
129446 | XIRP2 | NA | atenolol | ATENOLOL |
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