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Gene: HERC2 |
Gene summary for HERC2 |
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Gene information | Species | Human | Gene symbol | HERC2 | Gene ID | 8924 |
Gene name | HECT and RLD domain containing E3 ubiquitin protein ligase 2 | |
Gene Alias | D15F37S1 | |
Cytomap | 15q13.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A8KAQ8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8924 | HERC2 | CA_HPV_1 | Human | Cervix | CC | 7.51e-03 | -1.56e-02 | 0.0264 |
8924 | HERC2 | CCI_2 | Human | Cervix | CC | 2.15e-06 | 1.05e+00 | 0.5249 |
8924 | HERC2 | CCI_3 | Human | Cervix | CC | 4.88e-04 | 6.48e-01 | 0.516 |
8924 | HERC2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.60e-22 | -6.75e-01 | 0.0155 |
8924 | HERC2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.34e-07 | -5.43e-01 | -0.1808 |
8924 | HERC2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.54e-06 | -5.44e-01 | -0.1207 |
8924 | HERC2 | HTA11_5212_2000001011 | Human | Colorectum | AD | 3.33e-02 | -5.94e-01 | -0.2061 |
8924 | HERC2 | HTA11_5216_2000001011 | Human | Colorectum | SER | 4.57e-02 | -6.25e-01 | -0.1462 |
8924 | HERC2 | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.67e-04 | -6.39e-01 | -0.0179 |
8924 | HERC2 | HTA11_4255_2000001011 | Human | Colorectum | SER | 4.57e-02 | -5.76e-01 | 0.0446 |
8924 | HERC2 | HTA11_9408_2000001011 | Human | Colorectum | AD | 2.17e-02 | -4.50e-01 | 0.0451 |
8924 | HERC2 | HTA11_8622_2000001021 | Human | Colorectum | SER | 8.01e-03 | -4.49e-01 | 0.0528 |
8924 | HERC2 | HTA11_6818_2000001021 | Human | Colorectum | AD | 2.78e-04 | -3.81e-01 | 0.0588 |
8924 | HERC2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 7.09e-09 | -4.53e-01 | 0.294 |
8924 | HERC2 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.70e-21 | 1.25e+00 | 0.281 |
8924 | HERC2 | A001-C-207 | Human | Colorectum | FAP | 2.32e-03 | -9.84e-02 | 0.1278 |
8924 | HERC2 | A015-C-203 | Human | Colorectum | FAP | 5.73e-37 | -2.32e-01 | -0.1294 |
8924 | HERC2 | A015-C-204 | Human | Colorectum | FAP | 1.96e-08 | -8.87e-02 | -0.0228 |
8924 | HERC2 | A014-C-040 | Human | Colorectum | FAP | 3.10e-08 | 4.27e-03 | -0.1184 |
8924 | HERC2 | A002-C-201 | Human | Colorectum | FAP | 6.39e-19 | -2.45e-01 | 0.0324 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0412014 | Cervix | CC | Ubiquitin mediated proteolysis | 49/1267 | 142/8465 | 4.26e-09 | 7.68e-08 | 4.54e-08 | 49 |
hsa0412015 | Cervix | CC | Ubiquitin mediated proteolysis | 49/1267 | 142/8465 | 4.26e-09 | 7.68e-08 | 4.54e-08 | 49 |
hsa04120 | Colorectum | AD | Ubiquitin mediated proteolysis | 58/2092 | 142/8465 | 1.46e-05 | 1.53e-04 | 9.76e-05 | 58 |
hsa041201 | Colorectum | AD | Ubiquitin mediated proteolysis | 58/2092 | 142/8465 | 1.46e-05 | 1.53e-04 | 9.76e-05 | 58 |
hsa041202 | Colorectum | SER | Ubiquitin mediated proteolysis | 39/1580 | 142/8465 | 6.18e-03 | 3.66e-02 | 2.66e-02 | 39 |
hsa041203 | Colorectum | SER | Ubiquitin mediated proteolysis | 39/1580 | 142/8465 | 6.18e-03 | 3.66e-02 | 2.66e-02 | 39 |
hsa041204 | Colorectum | MSS | Ubiquitin mediated proteolysis | 55/1875 | 142/8465 | 5.02e-06 | 6.00e-05 | 3.68e-05 | 55 |
hsa041205 | Colorectum | MSS | Ubiquitin mediated proteolysis | 55/1875 | 142/8465 | 5.02e-06 | 6.00e-05 | 3.68e-05 | 55 |
hsa041206 | Colorectum | FAP | Ubiquitin mediated proteolysis | 51/1404 | 142/8465 | 1.55e-08 | 5.84e-07 | 3.55e-07 | 51 |
hsa041207 | Colorectum | FAP | Ubiquitin mediated proteolysis | 51/1404 | 142/8465 | 1.55e-08 | 5.84e-07 | 3.55e-07 | 51 |
hsa041208 | Colorectum | CRC | Ubiquitin mediated proteolysis | 42/1091 | 142/8465 | 9.98e-08 | 6.67e-06 | 4.52e-06 | 42 |
hsa041209 | Colorectum | CRC | Ubiquitin mediated proteolysis | 42/1091 | 142/8465 | 9.98e-08 | 6.67e-06 | 4.52e-06 | 42 |
hsa0412026 | Esophagus | HGIN | Ubiquitin mediated proteolysis | 49/1383 | 142/8465 | 7.78e-08 | 1.33e-06 | 1.06e-06 | 49 |
hsa04120111 | Esophagus | HGIN | Ubiquitin mediated proteolysis | 49/1383 | 142/8465 | 7.78e-08 | 1.33e-06 | 1.06e-06 | 49 |
hsa0412027 | Esophagus | ESCC | Ubiquitin mediated proteolysis | 122/4205 | 142/8465 | 6.53e-20 | 7.29e-18 | 3.74e-18 | 122 |
hsa0412036 | Esophagus | ESCC | Ubiquitin mediated proteolysis | 122/4205 | 142/8465 | 6.53e-20 | 7.29e-18 | 3.74e-18 | 122 |
hsa0412010 | Liver | NAFLD | Ubiquitin mediated proteolysis | 44/1043 | 142/8465 | 2.59e-09 | 1.70e-07 | 1.37e-07 | 44 |
hsa0412011 | Liver | NAFLD | Ubiquitin mediated proteolysis | 44/1043 | 142/8465 | 2.59e-09 | 1.70e-07 | 1.37e-07 | 44 |
hsa0412021 | Liver | Cirrhotic | Ubiquitin mediated proteolysis | 72/2530 | 142/8465 | 1.32e-07 | 1.97e-06 | 1.21e-06 | 72 |
hsa0412031 | Liver | Cirrhotic | Ubiquitin mediated proteolysis | 72/2530 | 142/8465 | 1.32e-07 | 1.97e-06 | 1.21e-06 | 72 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HERC2 | SNV | Missense_Mutation | novel | c.4034N>A | p.Gly1345Asp | p.G1345D | O95714 | protein_coding | deleterious(0) | possibly_damaging(0.563) | TCGA-VQ-A91D-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
HERC2 | SNV | Missense_Mutation | novel | c.1988G>A | p.Arg663His | p.R663H | O95714 | protein_coding | tolerated(0.54) | possibly_damaging(0.493) | TCGA-VQ-A924-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
HERC2 | insertion | Frame_Shift_Ins | novel | c.9589_9590insC | p.Gln3197ProfsTer4 | p.Q3197Pfs*4 | O95714 | protein_coding | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
HERC2 | deletion | Frame_Shift_Del | novel | c.1582_1595delNNNNNNNNNNNNNN | p.Gly528CysfsTer7 | p.G528Cfs*7 | O95714 | protein_coding | TCGA-CD-8529-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | epirubicin | CR | ||
HERC2 | insertion | Frame_Shift_Ins | novel | c.4960_4961insA | p.Met1654AsnfsTer49 | p.M1654Nfs*49 | O95714 | protein_coding | TCGA-CG-4442-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
HERC2 | deletion | Frame_Shift_Del | c.541delN | p.Ser181ValfsTer85 | p.S181Vfs*85 | O95714 | protein_coding | TCGA-CG-4442-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
HERC2 | deletion | Frame_Shift_Del | c.541delN | p.Ser181ValfsTer85 | p.S181Vfs*85 | O95714 | protein_coding | TCGA-CG-4460-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PD | |||
HERC2 | deletion | Frame_Shift_Del | c.541delN | p.Ser181ValfsTer85 | p.S181Vfs*85 | O95714 | protein_coding | TCGA-CG-5723-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
HERC2 | SNV | Missense_Mutation | novel | c.6136C>A | p.Pro2046Thr | p.P2046T | O95714 | protein_coding | deleterious(0.04) | benign(0.015) | TCGA-EM-A22J-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HERC2 | insertion | Frame_Shift_Ins | novel | c.8525_8526insCA | p.Ser2843IlefsTer9 | p.S2843Ifs*9 | O95714 | protein_coding | TCGA-FY-A40L-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Hormone Therapy | levothyroxine | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
8924 | HERC2 | DNA REPAIR, ENZYME | NERATINIB | NERATINIB | 23220880 |
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