Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/TP53_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/TP53_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/TP53_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/TP53_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/TP53_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/TP53_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0046034 | Colorectum | AD | ATP metabolic process | 142/3918 | 277/18723 | 2.64e-29 | 8.26e-26 | 142 |
GO:0006091 | Colorectum | AD | generation of precursor metabolites and energy | 209/3918 | 490/18723 | 3.17e-28 | 6.61e-25 | 209 |
GO:0015980 | Colorectum | AD | energy derivation by oxidation of organic compounds | 143/3918 | 318/18723 | 2.78e-22 | 2.49e-19 | 143 |
GO:0016032 | Colorectum | AD | viral process | 168/3918 | 415/18723 | 4.67e-20 | 3.66e-17 | 168 |
GO:0009896 | Colorectum | AD | positive regulation of catabolic process | 180/3918 | 492/18723 | 4.33e-16 | 1.94e-13 | 180 |
GO:0031331 | Colorectum | AD | positive regulation of cellular catabolic process | 156/3918 | 427/18723 | 4.68e-14 | 1.05e-11 | 156 |
GO:0009895 | Colorectum | AD | negative regulation of catabolic process | 124/3918 | 320/18723 | 1.66e-13 | 3.35e-11 | 124 |
GO:0006839 | Colorectum | AD | mitochondrial transport | 102/3918 | 254/18723 | 1.87e-12 | 3.08e-10 | 102 |
GO:0031330 | Colorectum | AD | negative regulation of cellular catabolic process | 104/3918 | 262/18723 | 2.66e-12 | 3.96e-10 | 104 |
GO:0072594 | Colorectum | AD | establishment of protein localization to organelle | 148/3918 | 422/18723 | 7.95e-12 | 1.04e-09 | 148 |
GO:0043254 | Colorectum | AD | regulation of protein-containing complex assembly | 148/3918 | 428/18723 | 2.64e-11 | 3.18e-09 | 148 |
GO:0097193 | Colorectum | AD | intrinsic apoptotic signaling pathway | 108/3918 | 288/18723 | 6.25e-11 | 6.41e-09 | 108 |
GO:0031334 | Colorectum | AD | positive regulation of protein-containing complex assembly | 91/3918 | 237/18723 | 4.78e-10 | 3.99e-08 | 91 |
GO:0031647 | Colorectum | AD | regulation of protein stability | 108/3918 | 298/18723 | 6.33e-10 | 5.08e-08 | 108 |
GO:0022411 | Colorectum | AD | cellular component disassembly | 147/3918 | 443/18723 | 8.53e-10 | 6.76e-08 | 147 |
GO:0010506 | Colorectum | AD | regulation of autophagy | 111/3918 | 317/18723 | 3.57e-09 | 2.35e-07 | 111 |
GO:2001242 | Colorectum | AD | regulation of intrinsic apoptotic signaling pathway | 67/3918 | 164/18723 | 4.94e-09 | 3.16e-07 | 67 |
GO:0006979 | Colorectum | AD | response to oxidative stress | 145/3918 | 446/18723 | 5.16e-09 | 3.23e-07 | 145 |
GO:0016236 | Colorectum | AD | macroautophagy | 103/3918 | 291/18723 | 6.76e-09 | 4.15e-07 | 103 |
GO:2001233 | Colorectum | AD | regulation of apoptotic signaling pathway | 119/3918 | 356/18723 | 2.14e-08 | 1.21e-06 | 119 |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
TP53 | MSC | Breast | DCIS | ATP1B2,CTNNB1,F2R, etc. | 1.47e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Breast/Str/TF_DCIS/regulons_activity_in_dotplot.png) |
TP53 | FIB | Breast | Healthy | ATP1B2,CTNNB1,F2R, etc. | 4.25e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Breast/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
TP53 | FIB | Breast | Precancer | ATP1B2,CTNNB1,F2R, etc. | 1.56e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Breast/Str/TF_Precancer/regulons_activity_in_dotplot.png) |
TP53 | ASC | Colorectum | ADJ | CATSPERE,AP000446.1,TMEM69, etc. | 1.30e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
TP53 | TAC | Colorectum | Healthy | ESYT1,ATAD5,GNL3, etc. | 7.42e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
TP53 | CD8TEXINT | Lung | AAH | APOLD1,RAB27A,PHACTR2-AS1, etc. | 3.56e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Lung/Str/TF_AAH/regulons_activity_in_dotplot.png) |
TP53 | TH1 | Lung | Healthy | TRAT1,MRPL43,LSM14A, etc. | 8.15e-03 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Lung/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
TP53 | CD8TCM | Lung | IAC | TTC4,ELMOD3,RNASE1, etc. | 4.42e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Lung/Str/TF_IAC/regulons_activity_in_dotplot.png) |
TP53 | CD8TEFF | Lung | IAC | TTC4,ELMOD3,RNASE1, etc. | 3.87e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Lung/Str/TF_IAC/regulons_activity_in_dotplot.png) |
TP53 | PVA | Lung | Healthy | HDX,LINC00960,NHEJ1, etc. | 1.10e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Lung/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TP53 | SNV | Missense_Mutation | rs730882000 | c.475N>C | p.Ala159Pro | p.A159P | P04637 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-B5-A3FD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
TP53 | SNV | Missense_Mutation | rs730881999 | c.380C>T | p.Ser127Phe | p.S127F | P04637 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-B5-A3S1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | paclitaxel | SD |
TP53 | SNV | Missense_Mutation | rs28934578 | c.524G>A | p.Arg175His | p.R175H | P04637 | protein_coding | tolerated(0.11) | benign(0.319) | TCGA-B5-A5OD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | SD |
TP53 | SNV | Missense_Mutation | rs121912657 | c.814G>A | p.Val272Met | p.V272M | P04637 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-BG-A0M6-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | paclitaxel | SD |
TP53 | SNV | Missense_Mutation | | c.713N>T | p.Cys238Phe | p.C238F | P04637 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BG-A0M7-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
TP53 | SNV | Missense_Mutation | rs121912666 | c.659N>G | p.Tyr220Cys | p.Y220C | P04637 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-BG-A0M8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TP53 | SNV | Missense_Mutation | rs11540652 | c.743N>A | p.Arg248Gln | p.R248Q | P04637 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-BG-A0YV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
TP53 | SNV | Missense_Mutation | rs121912666 | c.659N>G | p.Tyr220Cys | p.Y220C | P04637 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-BG-A18C-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TP53 | SNV | Missense_Mutation | rs121913343 | c.817N>T | p.Arg273Cys | p.R273C | P04637 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BG-A221-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TP53 | SNV | Missense_Mutation | rs587782664 | c.711N>A | p.Met237Ile | p.M237I | P04637 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BG-A3PP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | taxol | PD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7157 | TP53 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR COMPLEX, TUMOR SUPPRESSOR, DRUGGABLE GENOME, KINASE, DRUG RESISTANCE, TRANSPORTER | | CAULIBUGULONE D | CAULIBUGULONE D | |
7157 | TP53 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR COMPLEX, TUMOR SUPPRESSOR, DRUGGABLE GENOME, KINASE, DRUG RESISTANCE, TRANSPORTER | | fluorouracil | FLUOROURACIL | |
7157 | TP53 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR COMPLEX, TUMOR SUPPRESSOR, DRUGGABLE GENOME, KINASE, DRUG RESISTANCE, TRANSPORTER | | CID 867101 | CHEMBL406557 | |
7157 | TP53 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR COMPLEX, TUMOR SUPPRESSOR, DRUGGABLE GENOME, KINASE, DRUG RESISTANCE, TRANSPORTER | | SJ000276790 | CHEMBL602922 | |
7157 | TP53 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR COMPLEX, TUMOR SUPPRESSOR, DRUGGABLE GENOME, KINASE, DRUG RESISTANCE, TRANSPORTER | | OLEOYL DOPAMINE | OLEOYL DOPAMINE | |
7157 | TP53 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR COMPLEX, TUMOR SUPPRESSOR, DRUGGABLE GENOME, KINASE, DRUG RESISTANCE, TRANSPORTER | | DNDI1417085 | CHEMBL1522984 | |
7157 | TP53 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR COMPLEX, TUMOR SUPPRESSOR, DRUGGABLE GENOME, KINASE, DRUG RESISTANCE, TRANSPORTER | | DNDI1340257 | CHEMBL1702181 | |
7157 | TP53 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR COMPLEX, TUMOR SUPPRESSOR, DRUGGABLE GENOME, KINASE, DRUG RESISTANCE, TRANSPORTER | | TEBUFENPYRAD | TEBUFENPYRAD | |
7157 | TP53 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR COMPLEX, TUMOR SUPPRESSOR, DRUGGABLE GENOME, KINASE, DRUG RESISTANCE, TRANSPORTER | | CTX-1 | | 26883273 |
7157 | TP53 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR COMPLEX, TUMOR SUPPRESSOR, DRUGGABLE GENOME, KINASE, DRUG RESISTANCE, TRANSPORTER | | ZM-336372 | CHEMBL186526 | |