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Gene: ZSWIM5 |
Gene summary for ZSWIM5 |
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Gene information | Species | Human | Gene symbol | ZSWIM5 | Gene ID | 57643 |
Gene name | zinc finger SWIM-type containing 5 | |
Gene Alias | ZSWIM5 | |
Cytomap | 1p34.1 | |
Gene Type | protein-coding | GO ID | GO:0000151 | UniProtAcc | Q9P217 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57643 | ZSWIM5 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.80e-06 | -3.34e-01 | 0.0155 |
57643 | ZSWIM5 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 3.12e-03 | -4.93e-01 | 0.2585 |
57643 | ZSWIM5 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.94e-20 | -5.84e-01 | 0.3005 |
57643 | ZSWIM5 | F007 | Human | Colorectum | FAP | 3.80e-02 | 4.32e-02 | 0.1176 |
57643 | ZSWIM5 | A002-C-010 | Human | Colorectum | FAP | 1.73e-02 | 2.21e-01 | 0.242 |
57643 | ZSWIM5 | A015-C-203 | Human | Colorectum | FAP | 8.54e-25 | -3.34e-01 | -0.1294 |
57643 | ZSWIM5 | A015-C-204 | Human | Colorectum | FAP | 3.54e-08 | -3.06e-01 | -0.0228 |
57643 | ZSWIM5 | A014-C-040 | Human | Colorectum | FAP | 2.41e-03 | -1.62e-01 | -0.1184 |
57643 | ZSWIM5 | A002-C-201 | Human | Colorectum | FAP | 2.24e-09 | -1.05e-01 | 0.0324 |
57643 | ZSWIM5 | A001-C-119 | Human | Colorectum | FAP | 1.99e-08 | -3.75e-01 | -0.1557 |
57643 | ZSWIM5 | A001-C-108 | Human | Colorectum | FAP | 1.12e-11 | -1.46e-01 | -0.0272 |
57643 | ZSWIM5 | A002-C-205 | Human | Colorectum | FAP | 5.66e-24 | -3.74e-01 | -0.1236 |
57643 | ZSWIM5 | A001-C-104 | Human | Colorectum | FAP | 3.20e-02 | -5.97e-02 | 0.0184 |
57643 | ZSWIM5 | A015-C-005 | Human | Colorectum | FAP | 1.56e-02 | -1.57e-01 | -0.0336 |
57643 | ZSWIM5 | A015-C-006 | Human | Colorectum | FAP | 1.19e-19 | -5.98e-01 | -0.0994 |
57643 | ZSWIM5 | A015-C-106 | Human | Colorectum | FAP | 1.91e-07 | -4.88e-02 | -0.0511 |
57643 | ZSWIM5 | A002-C-114 | Human | Colorectum | FAP | 2.75e-19 | -2.32e-01 | -0.1561 |
57643 | ZSWIM5 | A015-C-104 | Human | Colorectum | FAP | 2.67e-28 | -4.76e-01 | -0.1899 |
57643 | ZSWIM5 | A001-C-014 | Human | Colorectum | FAP | 8.68e-11 | -1.68e-01 | 0.0135 |
57643 | ZSWIM5 | A002-C-016 | Human | Colorectum | FAP | 7.44e-16 | -1.36e-01 | 0.0521 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZSWIM5 | SNV | Missense_Mutation | c.2303T>C | p.Leu768Ser | p.L768S | Q9P217 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-78-7159-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZSWIM5 | SNV | Missense_Mutation | rs751715498 | c.3409N>C | p.Glu1137Gln | p.E1137Q | Q9P217 | protein_coding | deleterious(0.02) | benign(0.295) | TCGA-21-1078-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ZSWIM5 | SNV | Missense_Mutation | c.2291N>A | p.Arg764Lys | p.R764K | Q9P217 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-22-5485-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
ZSWIM5 | SNV | Missense_Mutation | novel | c.1752G>C | p.Lys584Asn | p.K584N | Q9P217 | protein_coding | tolerated(0.15) | benign(0.198) | TCGA-43-A56U-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZSWIM5 | SNV | Missense_Mutation | c.2317T>A | p.Ser773Thr | p.S773T | Q9P217 | protein_coding | tolerated(0.1) | benign(0.333) | TCGA-60-2726-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ZSWIM5 | SNV | Missense_Mutation | novel | c.2565N>A | p.Ser855Arg | p.S855R | Q9P217 | protein_coding | tolerated(0.12) | benign(0.438) | TCGA-63-A5MG-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZSWIM5 | SNV | Missense_Mutation | novel | c.3181N>C | p.Ile1061Leu | p.I1061L | Q9P217 | protein_coding | tolerated(0.13) | benign(0.328) | TCGA-66-2771-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | CR |
ZSWIM5 | SNV | Missense_Mutation | c.2956A>G | p.Ile986Val | p.I986V | Q9P217 | protein_coding | tolerated(0.22) | possibly_damaging(0.77) | TCGA-70-6722-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | |
ZSWIM5 | SNV | Missense_Mutation | novel | c.1045N>G | p.Leu349Val | p.L349V | Q9P217 | protein_coding | tolerated(0.08) | possibly_damaging(0.612) | TCGA-77-A5GB-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ZSWIM5 | SNV | Missense_Mutation | novel | c.2773N>A | p.Ala925Thr | p.A925T | Q9P217 | protein_coding | tolerated(1) | benign(0.009) | TCGA-MF-A522-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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