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Gene: ZNF791 |
Gene summary for ZNF791 |
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Gene information | Species | Human | Gene symbol | ZNF791 | Gene ID | 163049 |
Gene name | zinc finger protein 791 | |
Gene Alias | ZNF791 | |
Cytomap | 19p13.13 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q3KP31 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
163049 | ZNF791 | LZE4T | Human | Esophagus | ESCC | 6.95e-05 | 1.05e-01 | 0.0811 |
163049 | ZNF791 | LZE7T | Human | Esophagus | ESCC | 4.20e-12 | 6.24e-01 | 0.0667 |
163049 | ZNF791 | LZE24T | Human | Esophagus | ESCC | 5.81e-07 | 2.23e-01 | 0.0596 |
163049 | ZNF791 | LZE21T | Human | Esophagus | ESCC | 4.49e-04 | 2.11e-01 | 0.0655 |
163049 | ZNF791 | P1T-E | Human | Esophagus | ESCC | 1.55e-09 | 3.59e-01 | 0.0875 |
163049 | ZNF791 | P2T-E | Human | Esophagus | ESCC | 4.45e-14 | 1.24e-01 | 0.1177 |
163049 | ZNF791 | P4T-E | Human | Esophagus | ESCC | 4.36e-10 | 2.22e-01 | 0.1323 |
163049 | ZNF791 | P5T-E | Human | Esophagus | ESCC | 7.48e-12 | 8.70e-02 | 0.1327 |
163049 | ZNF791 | P8T-E | Human | Esophagus | ESCC | 3.06e-20 | 3.71e-01 | 0.0889 |
163049 | ZNF791 | P9T-E | Human | Esophagus | ESCC | 2.78e-15 | 2.08e-01 | 0.1131 |
163049 | ZNF791 | P10T-E | Human | Esophagus | ESCC | 3.99e-31 | 5.18e-01 | 0.116 |
163049 | ZNF791 | P11T-E | Human | Esophagus | ESCC | 5.53e-09 | 2.20e-01 | 0.1426 |
163049 | ZNF791 | P12T-E | Human | Esophagus | ESCC | 4.66e-17 | 3.25e-01 | 0.1122 |
163049 | ZNF791 | P15T-E | Human | Esophagus | ESCC | 4.81e-05 | 1.26e-01 | 0.1149 |
163049 | ZNF791 | P16T-E | Human | Esophagus | ESCC | 6.68e-12 | 2.21e-01 | 0.1153 |
163049 | ZNF791 | P17T-E | Human | Esophagus | ESCC | 1.55e-04 | 2.41e-01 | 0.1278 |
163049 | ZNF791 | P20T-E | Human | Esophagus | ESCC | 2.91e-09 | 2.08e-01 | 0.1124 |
163049 | ZNF791 | P21T-E | Human | Esophagus | ESCC | 5.82e-11 | 1.52e-01 | 0.1617 |
163049 | ZNF791 | P22T-E | Human | Esophagus | ESCC | 2.37e-23 | 2.51e-01 | 0.1236 |
163049 | ZNF791 | P23T-E | Human | Esophagus | ESCC | 2.30e-11 | 2.94e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF791 | SNV | Missense_Mutation | novel | c.1232N>T | p.Pro411Leu | p.P411L | Q3KP31 | protein_coding | deleterious(0.02) | probably_damaging(0.993) | TCGA-CQ-5326-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ZNF791 | SNV | Missense_Mutation | rs200738829 | c.473N>G | p.Lys158Arg | p.K158R | Q3KP31 | protein_coding | tolerated(0.08) | benign(0.013) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF791 | deletion | Frame_Shift_Del | novel | c.142delG | p.Glu48LysfsTer16 | p.E48Kfs*16 | Q3KP31 | protein_coding | TCGA-CV-7430-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | ||
ZNF791 | SNV | Missense_Mutation | novel | c.284N>T | p.Ala95Val | p.A95V | Q3KP31 | protein_coding | tolerated(0.07) | benign(0.035) | TCGA-EJ-7782-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 8 | Unknown | Unknown | SD |
ZNF791 | SNV | Missense_Mutation | rs768835879 | c.332G>A | p.Arg111His | p.R111H | Q3KP31 | protein_coding | tolerated(0.9) | benign(0) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
ZNF791 | SNV | Missense_Mutation | novel | c.952N>T | p.His318Tyr | p.H318Y | Q3KP31 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-VQ-A8PJ-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
ZNF791 | insertion | Frame_Shift_Ins | novel | c.1158_1159insA | p.Cys389MetfsTer25 | p.C389Mfs*25 | Q3KP31 | protein_coding | TCGA-CD-A4MG-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
ZNF791 | SNV | Missense_Mutation | c.1571N>G | p.Tyr524Cys | p.Y524C | Q3KP31 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-EL-A3T0-01 | Thyroid | thyroid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
ZNF791 | SNV | Missense_Mutation | rs550302847 | c.1390G>A | p.Gly464Arg | p.G464R | Q3KP31 | protein_coding | deleterious(0.04) | probably_damaging(0.998) | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
ZNF791 | insertion | Frame_Shift_Ins | novel | c.1388_1389insATTTTTTACATTCG | p.Gly464PhefsTer57 | p.G464Ffs*57 | Q3KP31 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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