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Gene: ZNF662 |
Gene summary for ZNF662 |
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Gene information | Species | Human | Gene symbol | ZNF662 | Gene ID | 389114 |
Gene name | zinc finger protein 662 | |
Gene Alias | ZNF662 | |
Cytomap | 3p22.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q6ZS27 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
389114 | ZNF662 | HCC1 | Human | Liver | HCC | 2.20e-11 | 1.32e+00 | 0.5336 |
389114 | ZNF662 | HCC2 | Human | Liver | HCC | 3.44e-15 | 1.83e+00 | 0.5341 |
389114 | ZNF662 | HCC5 | Human | Liver | HCC | 2.00e-12 | 1.45e+00 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF662 | SNV | Missense_Mutation | c.190N>A | p.Glu64Lys | p.E64K | Q6ZS27 | protein_coding | deleterious(0) | benign(0.418) | TCGA-50-6593-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
ZNF662 | SNV | Missense_Mutation | novel | c.256N>C | p.Glu86Gln | p.E86Q | Q6ZS27 | protein_coding | deleterious(0) | possibly_damaging(0.787) | TCGA-55-8089-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF662 | SNV | Missense_Mutation | novel | c.405N>T | p.Met135Ile | p.M135I | Q6ZS27 | protein_coding | tolerated(0.46) | benign(0) | TCGA-69-7974-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
ZNF662 | SNV | Missense_Mutation | rs774489250 | c.642G>T | p.Glu214Asp | p.E214D | Q6ZS27 | protein_coding | tolerated(0.28) | benign(0.223) | TCGA-33-4538-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
ZNF662 | SNV | Missense_Mutation | novel | c.1037T>C | p.Leu346Pro | p.L346P | Q6ZS27 | protein_coding | deleterious(0) | possibly_damaging(0.649) | TCGA-56-7222-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
ZNF662 | SNV | Missense_Mutation | novel | c.160N>A | p.Gln54Lys | p.Q54K | Q6ZS27 | protein_coding | deleterious(0.01) | possibly_damaging(0.499) | TCGA-66-2759-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | CR |
ZNF662 | SNV | Missense_Mutation | novel | c.199N>C | p.Gly67Arg | p.G67R | Q6ZS27 | protein_coding | tolerated(0.15) | probably_damaging(0.977) | TCGA-L3-A524-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ZNF662 | SNV | Missense_Mutation | c.730A>C | p.Lys244Gln | p.K244Q | Q6ZS27 | protein_coding | deleterious(0.02) | benign(0.114) | TCGA-BR-8589-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
ZNF662 | SNV | Missense_Mutation | c.1217N>A | p.Arg406Lys | p.R406K | Q6ZS27 | protein_coding | deleterious(0.04) | probably_damaging(0.986) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
ZNF662 | SNV | Missense_Mutation | novel | c.1147G>A | p.Asp383Asn | p.D383N | Q6ZS27 | protein_coding | deleterious(0.03) | benign(0) | TCGA-HU-A4GT-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | copolang | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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