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Gene: ZNF571 |
Gene summary for ZNF571 |
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Gene information | Species | Human | Gene symbol | ZNF571 | Gene ID | 51276 |
Gene name | zinc finger protein 571 | |
Gene Alias | HSPC059 | |
Cytomap | 19q13.12 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A024R0L0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51276 | ZNF571 | male-WTA | Human | Thyroid | PTC | 3.11e-03 | 2.26e-02 | 0.1037 |
51276 | ZNF571 | PTC01 | Human | Thyroid | PTC | 1.07e-05 | 1.22e-02 | 0.1899 |
51276 | ZNF571 | PTC04 | Human | Thyroid | PTC | 1.61e-04 | 4.75e-02 | 0.1927 |
51276 | ZNF571 | PTC05 | Human | Thyroid | PTC | 1.13e-02 | 9.10e-02 | 0.2065 |
51276 | ZNF571 | PTC06 | Human | Thyroid | PTC | 8.79e-07 | 1.06e-01 | 0.2057 |
51276 | ZNF571 | PTC07 | Human | Thyroid | PTC | 2.38e-06 | 7.98e-02 | 0.2044 |
51276 | ZNF571 | ATC13 | Human | Thyroid | ATC | 5.20e-43 | 7.16e-01 | 0.34 |
51276 | ZNF571 | ATC2 | Human | Thyroid | ATC | 1.77e-02 | 2.09e-01 | 0.34 |
51276 | ZNF571 | ATC5 | Human | Thyroid | ATC | 8.85e-40 | 7.58e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF571 | SNV | Missense_Mutation | c.1296N>T | p.Lys432Asn | p.K432N | Q7Z3V5 | protein_coding | deleterious(0.04) | benign(0.148) | TCGA-35-4122-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZNF571 | SNV | Missense_Mutation | novel | c.74N>A | p.Pro25His | p.P25H | Q7Z3V5 | protein_coding | deleterious(0.04) | benign(0.382) | TCGA-53-7626-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unspecific | Cisplatin | PD |
ZNF571 | SNV | Missense_Mutation | c.1598N>C | p.Lys533Thr | p.K533T | Q7Z3V5 | protein_coding | deleterious(0.03) | benign(0.377) | TCGA-55-6969-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ZNF571 | SNV | Missense_Mutation | c.1423N>C | p.Glu475Gln | p.E475Q | Q7Z3V5 | protein_coding | tolerated(0.07) | benign(0.212) | TCGA-55-8208-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZNF571 | SNV | Missense_Mutation | c.1351G>A | p.Glu451Lys | p.E451K | Q7Z3V5 | protein_coding | deleterious(0.03) | possibly_damaging(0.76) | TCGA-55-A491-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF571 | SNV | Missense_Mutation | rs775259902 | c.1705N>T | p.Arg569Cys | p.R569C | Q7Z3V5 | protein_coding | tolerated(0.16) | benign(0.054) | TCGA-64-1677-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | gemcitabine | PD |
ZNF571 | SNV | Missense_Mutation | novel | c.1606N>T | p.Gly536Trp | p.G536W | Q7Z3V5 | protein_coding | deleterious(0) | possibly_damaging(0.832) | TCGA-18-3410-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF571 | SNV | Missense_Mutation | novel | c.1186N>C | p.Cys396Arg | p.C396R | Q7Z3V5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-21-1083-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF571 | SNV | Missense_Mutation | novel | c.1352A>C | p.Glu451Ala | p.E451A | Q7Z3V5 | protein_coding | deleterious(0.03) | probably_damaging(0.984) | TCGA-22-1005-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF571 | SNV | Missense_Mutation | c.1390N>G | p.Gln464Glu | p.Q464E | Q7Z3V5 | protein_coding | tolerated(0.27) | benign(0.392) | TCGA-22-1011-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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