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Gene: ZNF496 |
Gene summary for ZNF496 |
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Gene information | Species | Human | Gene symbol | ZNF496 | Gene ID | 84838 |
Gene name | zinc finger protein 496 | |
Gene Alias | NIZP1 | |
Cytomap | 1q44 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A024R5Q5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84838 | ZNF496 | HCC1_Meng | Human | Liver | HCC | 2.06e-25 | 5.30e-02 | 0.0246 |
84838 | ZNF496 | HCC1 | Human | Liver | HCC | 8.25e-03 | 2.85e+00 | 0.5336 |
84838 | ZNF496 | HCC2 | Human | Liver | HCC | 4.91e-02 | 1.00e+00 | 0.5341 |
84838 | ZNF496 | S014 | Human | Liver | HCC | 1.56e-12 | 3.96e-01 | 0.2254 |
84838 | ZNF496 | S015 | Human | Liver | HCC | 6.57e-07 | 3.21e-01 | 0.2375 |
84838 | ZNF496 | S016 | Human | Liver | HCC | 5.06e-11 | 3.47e-01 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF496 | SNV | Missense_Mutation | c.434N>T | p.Ser145Ile | p.S145I | Q96IT1 | protein_coding | tolerated(0.14) | benign(0.086) | TCGA-44-7667-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF496 | SNV | Missense_Mutation | c.57N>T | p.Arg19Ser | p.R19S | Q96IT1 | protein_coding | deleterious_low_confidence(0.03) | possibly_damaging(0.746) | TCGA-49-AARE-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
ZNF496 | SNV | Missense_Mutation | c.898N>G | p.Pro300Ala | p.P300A | Q96IT1 | protein_coding | tolerated(0.21) | benign(0.018) | TCGA-55-1595-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF496 | SNV | Missense_Mutation | c.1138N>A | p.Glu380Lys | p.E380K | Q96IT1 | protein_coding | tolerated(0.34) | benign(0.031) | TCGA-55-6968-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | unknown | PD | |
ZNF496 | SNV | Missense_Mutation | novel | c.1460N>C | p.Gln487Pro | p.Q487P | Q96IT1 | protein_coding | tolerated(0.22) | benign(0) | TCGA-55-8507-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF496 | SNV | Missense_Mutation | c.1287N>T | p.Arg429Ser | p.R429S | Q96IT1 | protein_coding | deleterious(0.01) | benign(0.04) | TCGA-55-8507-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ZNF496 | SNV | Missense_Mutation | c.1286N>T | p.Arg429Met | p.R429M | Q96IT1 | protein_coding | deleterious(0) | benign(0.436) | TCGA-55-8507-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ZNF496 | SNV | Missense_Mutation | c.128G>T | p.Arg43Leu | p.R43L | Q96IT1 | protein_coding | deleterious(0.03) | probably_damaging(0.986) | TCGA-78-7542-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ZNF496 | SNV | Missense_Mutation | c.1169N>C | p.Arg390Pro | p.R390P | Q96IT1 | protein_coding | deleterious(0.02) | benign(0.324) | TCGA-86-8073-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ZNF496 | SNV | Missense_Mutation | c.287G>T | p.Arg96Leu | p.R96L | Q96IT1 | protein_coding | tolerated(0.26) | benign(0.23) | TCGA-86-8358-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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