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Gene: ZNF491 |
Gene summary for ZNF491 |
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Gene information | Species | Human | Gene symbol | ZNF491 | Gene ID | 126069 |
Gene name | zinc finger protein 491 | |
Gene Alias | ZNF491 | |
Cytomap | 19p13.2 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q8N8L2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
126069 | ZNF491 | HCC1 | Human | Liver | HCC | 8.27e-05 | 4.46e-01 | 0.5336 |
126069 | ZNF491 | HCC2 | Human | Liver | HCC | 5.93e-12 | 8.85e-01 | 0.5341 |
126069 | ZNF491 | HCC5 | Human | Liver | HCC | 3.25e-10 | 6.16e-01 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF491 | SNV | Missense_Mutation | rs768884740 | c.452N>A | p.Arg151Gln | p.R151Q | Q8N8L2 | protein_coding | deleterious(0.01) | possibly_damaging(0.788) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF491 | SNV | Missense_Mutation | c.1040G>C | p.Arg347Thr | p.R347T | Q8N8L2 | protein_coding | deleterious(0.02) | possibly_damaging(0.815) | TCGA-05-4382-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ZNF491 | SNV | Missense_Mutation | c.224A>G | p.Tyr75Cys | p.Y75C | Q8N8L2 | protein_coding | tolerated(0.06) | benign(0.007) | TCGA-55-7725-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF491 | SNV | Missense_Mutation | c.803N>T | p.Glu268Val | p.E268V | Q8N8L2 | protein_coding | deleterious(0.03) | benign(0.005) | TCGA-67-3771-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF491 | SNV | Missense_Mutation | novel | c.661G>T | p.Gly221Trp | p.G221W | Q8N8L2 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-NJ-A4YQ-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF491 | SNV | Missense_Mutation | novel | c.652A>G | p.Lys218Glu | p.K218E | Q8N8L2 | protein_coding | deleterious(0.03) | benign(0.347) | TCGA-60-2721-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF491 | SNV | Missense_Mutation | novel | c.1265N>T | p.Arg422Leu | p.R422L | Q8N8L2 | protein_coding | tolerated(0.61) | benign(0) | TCGA-85-A4CL-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF491 | deletion | Frame_Shift_Del | novel | c.841delT | p.Tyr281ThrfsTer164 | p.Y281Tfs*164 | Q8N8L2 | protein_coding | TCGA-55-8506-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ZNF491 | insertion | In_Frame_Ins | novel | c.561_562insATCTTC | p.Tyr187_Glu188insIlePhe | p.Y187_E188insIF | Q8N8L2 | protein_coding | TCGA-86-A4D0-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | etoposide | CR | ||
ZNF491 | SNV | Missense_Mutation | c.536N>T | p.Arg179Ile | p.R179I | Q8N8L2 | protein_coding | tolerated(0.1) | possibly_damaging(0.562) | TCGA-BB-A5HZ-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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