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Gene: ZNF44 |
Gene summary for ZNF44 |
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Gene information | Species | Human | Gene symbol | ZNF44 | Gene ID | 51710 |
Gene name | zinc finger protein 44 | |
Gene Alias | GIOT-2 | |
Cytomap | 19p13.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P15621 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51710 | ZNF44 | NAFLD1 | Human | Liver | NAFLD | 1.84e-05 | 5.62e-01 | -0.04 |
51710 | ZNF44 | S43 | Human | Liver | Cirrhotic | 6.31e-07 | -1.09e-01 | -0.0187 |
51710 | ZNF44 | HCC1_Meng | Human | Liver | HCC | 1.71e-24 | -3.74e-02 | 0.0246 |
51710 | ZNF44 | HCC2_Meng | Human | Liver | HCC | 7.28e-03 | -7.81e-02 | 0.0107 |
51710 | ZNF44 | HCC2 | Human | Liver | HCC | 4.02e-06 | 2.60e+00 | 0.5341 |
51710 | ZNF44 | HCC5 | Human | Liver | HCC | 3.42e-04 | 9.76e-01 | 0.4932 |
51710 | ZNF44 | male-WTA | Human | Thyroid | PTC | 6.56e-12 | 4.42e-02 | 0.1037 |
51710 | ZNF44 | PTC01 | Human | Thyroid | PTC | 1.86e-12 | 2.30e-01 | 0.1899 |
51710 | ZNF44 | PTC03 | Human | Thyroid | PTC | 1.67e-02 | 1.42e-01 | 0.1784 |
51710 | ZNF44 | PTC04 | Human | Thyroid | PTC | 3.78e-18 | 2.60e-01 | 0.1927 |
51710 | ZNF44 | PTC05 | Human | Thyroid | PTC | 3.22e-21 | 5.79e-01 | 0.2065 |
51710 | ZNF44 | PTC06 | Human | Thyroid | PTC | 1.54e-22 | 4.63e-01 | 0.2057 |
51710 | ZNF44 | PTC07 | Human | Thyroid | PTC | 5.77e-19 | 3.11e-01 | 0.2044 |
51710 | ZNF44 | ATC11 | Human | Thyroid | ATC | 3.39e-02 | 1.97e-01 | 0.3386 |
51710 | ZNF44 | ATC12 | Human | Thyroid | ATC | 3.74e-11 | 1.07e-01 | 0.34 |
51710 | ZNF44 | ATC13 | Human | Thyroid | ATC | 5.11e-10 | 2.10e-01 | 0.34 |
51710 | ZNF44 | ATC2 | Human | Thyroid | ATC | 5.61e-06 | 5.11e-01 | 0.34 |
51710 | ZNF44 | ATC3 | Human | Thyroid | ATC | 1.66e-02 | 2.10e-01 | 0.338 |
51710 | ZNF44 | ATC4 | Human | Thyroid | ATC | 2.54e-14 | 1.40e-01 | 0.34 |
51710 | ZNF44 | ATC5 | Human | Thyroid | ATC | 1.39e-24 | 2.38e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF44 | SNV | Missense_Mutation | novel | c.1883G>T | p.Arg628Ile | p.R628I | P15621 | protein_coding | deleterious(0.02) | probably_damaging(0.931) | TCGA-QF-A5YS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
ZNF44 | deletion | Frame_Shift_Del | c.766delN | p.Trp256GlyfsTer34 | p.W256Gfs*34 | P15621 | protein_coding | TCGA-AX-A2IN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |||
ZNF44 | deletion | Frame_Shift_Del | c.766delN | p.Trp256GlyfsTer34 | p.W256Gfs*34 | P15621 | protein_coding | TCGA-BS-A0UA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |||
ZNF44 | SNV | Missense_Mutation | rs61737488 | c.1072A>G | p.Thr358Ala | p.T358A | P15621 | protein_coding | tolerated(0.1) | benign(0) | TCGA-MI-A75G-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF44 | SNV | Missense_Mutation | novel | c.1636N>A | p.His546Asn | p.H546N | P15621 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-05-4396-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
ZNF44 | SNV | Missense_Mutation | novel | c.958N>A | p.Glu320Lys | p.E320K | P15621 | protein_coding | tolerated(0.23) | benign(0.095) | TCGA-55-7995-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR |
ZNF44 | SNV | Missense_Mutation | novel | c.940N>T | p.Ser314Cys | p.S314C | P15621 | protein_coding | tolerated(0.08) | probably_damaging(0.969) | TCGA-75-6211-01 | Lung | lung adenocarcinoma | Female | Unknown | I/II | Unknown | Unknown | PD |
ZNF44 | SNV | Missense_Mutation | c.1415N>G | p.Lys472Arg | p.K472R | P15621 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-78-7158-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD | |
ZNF44 | SNV | Missense_Mutation | c.787N>T | p.His263Tyr | p.H263Y | P15621 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-78-8660-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ZNF44 | SNV | Missense_Mutation | novel | c.1277N>T | p.Ser426Leu | p.S426L | P15621 | protein_coding | tolerated(0.05) | probably_damaging(0.971) | TCGA-91-8499-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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