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Gene: ZNF426 |
Gene summary for ZNF426 |
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Gene information | Species | Human | Gene symbol | ZNF426 | Gene ID | 79088 |
Gene name | zinc finger protein 426 | |
Gene Alias | K-RBP | |
Cytomap | 19p13.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | K7ER43 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79088 | ZNF426 | LZE5T | Human | Esophagus | ESCC | 1.57e-02 | 2.08e-01 | 0.0514 |
79088 | ZNF426 | LZE8T | Human | Esophagus | ESCC | 1.10e-02 | 7.76e-02 | 0.067 |
79088 | ZNF426 | LZE20T | Human | Esophagus | ESCC | 7.18e-07 | 2.07e-01 | 0.0662 |
79088 | ZNF426 | LZE24T | Human | Esophagus | ESCC | 2.65e-05 | 1.27e-01 | 0.0596 |
79088 | ZNF426 | LZE21T | Human | Esophagus | ESCC | 1.37e-06 | 3.00e-01 | 0.0655 |
79088 | ZNF426 | P1T-E | Human | Esophagus | ESCC | 1.05e-09 | 3.04e-01 | 0.0875 |
79088 | ZNF426 | P2T-E | Human | Esophagus | ESCC | 2.83e-25 | 4.09e-01 | 0.1177 |
79088 | ZNF426 | P4T-E | Human | Esophagus | ESCC | 5.16e-10 | 1.91e-01 | 0.1323 |
79088 | ZNF426 | P5T-E | Human | Esophagus | ESCC | 1.30e-07 | 1.56e-01 | 0.1327 |
79088 | ZNF426 | P8T-E | Human | Esophagus | ESCC | 1.88e-16 | 3.33e-01 | 0.0889 |
79088 | ZNF426 | P9T-E | Human | Esophagus | ESCC | 2.38e-11 | 2.16e-01 | 0.1131 |
79088 | ZNF426 | P10T-E | Human | Esophagus | ESCC | 8.82e-23 | 3.72e-01 | 0.116 |
79088 | ZNF426 | P11T-E | Human | Esophagus | ESCC | 3.25e-05 | 2.08e-01 | 0.1426 |
79088 | ZNF426 | P12T-E | Human | Esophagus | ESCC | 4.28e-16 | 2.88e-01 | 0.1122 |
79088 | ZNF426 | P15T-E | Human | Esophagus | ESCC | 3.16e-13 | 2.03e-01 | 0.1149 |
79088 | ZNF426 | P16T-E | Human | Esophagus | ESCC | 7.05e-12 | 2.92e-01 | 0.1153 |
79088 | ZNF426 | P17T-E | Human | Esophagus | ESCC | 4.79e-04 | 1.63e-01 | 0.1278 |
79088 | ZNF426 | P20T-E | Human | Esophagus | ESCC | 6.20e-06 | 1.28e-01 | 0.1124 |
79088 | ZNF426 | P21T-E | Human | Esophagus | ESCC | 3.65e-12 | 2.67e-01 | 0.1617 |
79088 | ZNF426 | P24T-E | Human | Esophagus | ESCC | 2.68e-06 | 1.22e-01 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF426 | SNV | Missense_Mutation | c.1076G>T | p.Ser359Ile | p.S359I | Q9BUY5 | protein_coding | deleterious(0.04) | possibly_damaging(0.659) | TCGA-18-3421-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZNF426 | SNV | Missense_Mutation | c.803N>T | p.Ser268Phe | p.S268F | Q9BUY5 | protein_coding | deleterious(0.01) | benign(0.102) | TCGA-21-1083-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZNF426 | SNV | Missense_Mutation | rs749082633 | c.620N>A | p.Ser207Asn | p.S207N | Q9BUY5 | protein_coding | tolerated(0.09) | benign(0.087) | TCGA-43-2578-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF426 | SNV | Missense_Mutation | novel | c.1427N>G | p.Tyr476Cys | p.Y476C | Q9BUY5 | protein_coding | deleterious(0) | probably_damaging(0.949) | TCGA-56-8309-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF426 | SNV | Missense_Mutation | c.1076G>T | p.Ser359Ile | p.S359I | Q9BUY5 | protein_coding | deleterious(0.04) | possibly_damaging(0.659) | TCGA-77-7141-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ZNF426 | deletion | Frame_Shift_Del | novel | c.513delN | p.Asn172ThrfsTer37 | p.N172Tfs*37 | Q9BUY5 | protein_coding | TCGA-85-8049-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
ZNF426 | SNV | Missense_Mutation | novel | c.251N>T | p.Gln84Leu | p.Q84L | Q9BUY5 | protein_coding | deleterious(0.03) | benign(0.001) | TCGA-BA-6873-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
ZNF426 | SNV | Missense_Mutation | novel | c.1401N>T | p.Met467Ile | p.M467I | Q9BUY5 | protein_coding | tolerated(1) | benign(0.034) | TCGA-CN-6992-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
ZNF426 | SNV | Missense_Mutation | novel | c.134N>G | p.Asp45Gly | p.D45G | Q9BUY5 | protein_coding | deleterious(0.01) | benign(0.086) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF426 | insertion | In_Frame_Ins | novel | c.1194_1195insTTA | p.Gly398_Lys399insLeu | p.G398_K399insL | Q9BUY5 | protein_coding | TCGA-H7-8502-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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