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Gene: ZNF234 |
Gene summary for ZNF234 |
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Gene information | Species | Human | Gene symbol | ZNF234 | Gene ID | 10780 |
Gene name | zinc finger protein 234 | |
Gene Alias | HZF4 | |
Cytomap | 19q13.31 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A024R0N3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10780 | ZNF234 | HCC1 | Human | Liver | HCC | 5.39e-08 | 1.38e+00 | 0.5336 |
10780 | ZNF234 | HCC2 | Human | Liver | HCC | 2.72e-16 | 1.75e+00 | 0.5341 |
10780 | ZNF234 | HCC5 | Human | Liver | HCC | 4.99e-24 | 2.40e+00 | 0.4932 |
10780 | ZNF234 | S028 | Human | Liver | HCC | 2.21e-02 | 1.42e-01 | 0.2503 |
10780 | ZNF234 | S029 | Human | Liver | HCC | 1.16e-02 | 1.49e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
ZNF234 | LYMEND | Stomach | SIM | MTERF1,METTL23,PABPN1, etc. | 5.17e-02 | ![]() |
ZNF234 | ICAF | Stomach | WIM | MTERF1,METTL23,PABPN1, etc. | 3.78e-02 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF234 | SNV | Missense_Mutation | c.1557G>T | p.Lys519Asn | p.K519N | Q14588 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-05-4382-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ZNF234 | SNV | Missense_Mutation | c.1021N>C | p.Glu341Gln | p.E341Q | Q14588 | protein_coding | deleterious(0) | possibly_damaging(0.609) | TCGA-05-5428-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR | |
ZNF234 | SNV | Missense_Mutation | novel | c.1312N>T | p.Arg438Cys | p.R438C | Q14588 | protein_coding | deleterious(0.03) | possibly_damaging(0.825) | TCGA-78-7161-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
ZNF234 | SNV | Missense_Mutation | c.1173N>T | p.Gln391His | p.Q391H | Q14588 | protein_coding | tolerated(0.11) | possibly_damaging(0.878) | TCGA-99-8025-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | gemzar | SD | |
ZNF234 | SNV | Missense_Mutation | novel | c.1808A>T | p.Lys603Met | p.K603M | Q14588 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-MN-A4N4-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF234 | SNV | Missense_Mutation | novel | c.959N>T | p.Asp320Val | p.D320V | Q14588 | protein_coding | tolerated(0.19) | possibly_damaging(0.778) | TCGA-21-1083-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF234 | SNV | Missense_Mutation | c.1007N>A | p.Arg336Lys | p.R336K | Q14588 | protein_coding | tolerated(0.08) | benign(0.023) | TCGA-22-4604-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Targeted Molecular therapy | iressa | PD | |
ZNF234 | SNV | Missense_Mutation | novel | c.1787N>G | p.Tyr596Cys | p.Y596C | Q14588 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-37-4132-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZNF234 | SNV | Missense_Mutation | c.997N>G | p.Ile333Val | p.I333V | Q14588 | protein_coding | tolerated(0.26) | probably_damaging(0.992) | TCGA-56-1622-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
ZNF234 | SNV | Missense_Mutation | novel | c.490G>C | p.Asp164His | p.D164H | Q14588 | protein_coding | deleterious(0.04) | possibly_damaging(0.885) | TCGA-56-7222-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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