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Gene: ZNF12 |
Gene summary for ZNF12 |
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Gene information | Species | Human | Gene symbol | ZNF12 | Gene ID | 7559 |
Gene name | zinc finger protein 12 | |
Gene Alias | GIOT-3 | |
Cytomap | 7p22.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P17014 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7559 | ZNF12 | HCC1_Meng | Human | Liver | HCC | 3.11e-43 | 3.90e-02 | 0.0246 |
7559 | ZNF12 | HCC2_Meng | Human | Liver | HCC | 5.26e-08 | 4.30e-02 | 0.0107 |
7559 | ZNF12 | HCC2 | Human | Liver | HCC | 4.14e-07 | 2.94e+00 | 0.5341 |
7559 | ZNF12 | S014 | Human | Liver | HCC | 7.74e-05 | 2.66e-01 | 0.2254 |
7559 | ZNF12 | S016 | Human | Liver | HCC | 3.12e-04 | 3.03e-01 | 0.2243 |
7559 | ZNF12 | S027 | Human | Liver | HCC | 1.48e-09 | 7.20e-01 | 0.2446 |
7559 | ZNF12 | S028 | Human | Liver | HCC | 4.75e-28 | 9.13e-01 | 0.2503 |
7559 | ZNF12 | S029 | Human | Liver | HCC | 4.09e-17 | 7.89e-01 | 0.2581 |
7559 | ZNF12 | C21 | Human | Oral cavity | OSCC | 6.29e-10 | 3.47e-01 | 0.2678 |
7559 | ZNF12 | C30 | Human | Oral cavity | OSCC | 7.36e-17 | 6.08e-01 | 0.3055 |
7559 | ZNF12 | C38 | Human | Oral cavity | OSCC | 4.02e-08 | 5.92e-01 | 0.172 |
7559 | ZNF12 | C43 | Human | Oral cavity | OSCC | 3.36e-05 | 1.36e-01 | 0.1704 |
7559 | ZNF12 | C46 | Human | Oral cavity | OSCC | 2.54e-04 | 1.58e-01 | 0.1673 |
7559 | ZNF12 | C51 | Human | Oral cavity | OSCC | 4.09e-02 | 2.31e-01 | 0.2674 |
7559 | ZNF12 | C08 | Human | Oral cavity | OSCC | 6.15e-21 | 3.98e-01 | 0.1919 |
7559 | ZNF12 | LP15 | Human | Oral cavity | LP | 4.26e-02 | 3.20e-01 | 0.2174 |
7559 | ZNF12 | SYSMH1 | Human | Oral cavity | OSCC | 3.77e-08 | 2.15e-01 | 0.1127 |
7559 | ZNF12 | SYSMH2 | Human | Oral cavity | OSCC | 4.37e-07 | 1.90e-01 | 0.2326 |
7559 | ZNF12 | SYSMH3 | Human | Oral cavity | OSCC | 2.70e-03 | 1.77e-01 | 0.2442 |
7559 | ZNF12 | male-WTA | Human | Thyroid | PTC | 7.11e-09 | 6.13e-02 | 0.1037 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
ZNF12 | ECC | Skin | ADJ | STEAP2,BMT2,SHLD1, etc. | 9.02e-02 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF12 | SNV | Missense_Mutation | rs369502322 | c.631C>T | p.Arg211Cys | p.R211C | P17014 | protein_coding | deleterious(0.01) | benign(0.28) | TCGA-EO-A3AV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
ZNF12 | SNV | Missense_Mutation | c.1622N>T | p.Arg541Ile | p.R541I | P17014 | protein_coding | deleterious(0) | benign(0.162) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
ZNF12 | SNV | Missense_Mutation | novel | c.1342N>T | p.Arg448Trp | p.R448W | P17014 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZNF12 | SNV | Missense_Mutation | novel | c.2010N>A | p.Phe670Leu | p.F670L | P17014 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF12 | SNV | Missense_Mutation | c.1706N>T | p.Arg569Ile | p.R569I | P17014 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF12 | SNV | Missense_Mutation | novel | c.1000T>A | p.Phe334Ile | p.F334I | P17014 | protein_coding | deleterious(0) | possibly_damaging(0.899) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
ZNF12 | deletion | In_Frame_Del | novel | c.1421_1423delNNN | p.Phe474del | p.F474del | P17014 | protein_coding | TCGA-BK-A13B-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | ||
ZNF12 | deletion | Frame_Shift_Del | novel | c.696delT | p.Phe232LeufsTer17 | p.F232Lfs*17 | P17014 | protein_coding | TCGA-D1-A2G5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | ||
ZNF12 | SNV | Missense_Mutation | novel | c.172N>T | p.Ser58Cys | p.S58C | P17014 | protein_coding | deleterious(0.04) | benign(0.106) | TCGA-DD-AAC8-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF12 | SNV | Missense_Mutation | c.370G>C | p.Glu124Gln | p.E124Q | P17014 | protein_coding | tolerated(0.46) | benign(0.058) | TCGA-35-3615-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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