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Gene: ZFHX3 |
Gene summary for ZFHX3 |
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Gene information | Species | Human | Gene symbol | ZFHX3 | Gene ID | 463 |
Gene name | zinc finger homeobox 3 | |
Gene Alias | ATBF1 | |
Cytomap | 16q22.2-q22.3 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q15911 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
463 | ZFHX3 | HTA11_3410_2000001011 | Human | Colorectum | AD | 6.82e-12 | -4.96e-01 | 0.0155 |
463 | ZFHX3 | HTA11_7663_2000001011 | Human | Colorectum | SER | 1.00e-03 | 6.80e-01 | 0.0131 |
463 | ZFHX3 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 8.78e-04 | -2.58e-01 | 0.294 |
463 | ZFHX3 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 3.68e-02 | -5.50e-01 | 0.2585 |
463 | ZFHX3 | F007 | Human | Colorectum | FAP | 2.34e-02 | -2.61e-01 | 0.1176 |
463 | ZFHX3 | A002-C-010 | Human | Colorectum | FAP | 4.06e-03 | -8.91e-02 | 0.242 |
463 | ZFHX3 | A001-C-207 | Human | Colorectum | FAP | 1.70e-02 | -1.56e-01 | 0.1278 |
463 | ZFHX3 | A015-C-203 | Human | Colorectum | FAP | 6.36e-38 | -5.45e-01 | -0.1294 |
463 | ZFHX3 | A015-C-204 | Human | Colorectum | FAP | 4.69e-05 | -2.53e-01 | -0.0228 |
463 | ZFHX3 | A014-C-040 | Human | Colorectum | FAP | 6.64e-05 | -2.29e-01 | -0.1184 |
463 | ZFHX3 | A002-C-201 | Human | Colorectum | FAP | 5.95e-14 | -2.28e-01 | 0.0324 |
463 | ZFHX3 | A002-C-203 | Human | Colorectum | FAP | 1.91e-02 | -4.49e-02 | 0.2786 |
463 | ZFHX3 | A001-C-119 | Human | Colorectum | FAP | 6.54e-07 | -2.24e-01 | -0.1557 |
463 | ZFHX3 | A001-C-108 | Human | Colorectum | FAP | 3.61e-25 | -3.67e-01 | -0.0272 |
463 | ZFHX3 | A002-C-205 | Human | Colorectum | FAP | 1.71e-23 | -3.04e-01 | -0.1236 |
463 | ZFHX3 | A001-C-104 | Human | Colorectum | FAP | 1.19e-03 | -2.24e-01 | 0.0184 |
463 | ZFHX3 | A015-C-005 | Human | Colorectum | FAP | 1.81e-05 | -2.38e-01 | -0.0336 |
463 | ZFHX3 | A015-C-006 | Human | Colorectum | FAP | 1.04e-19 | -5.30e-01 | -0.0994 |
463 | ZFHX3 | A015-C-106 | Human | Colorectum | FAP | 2.04e-16 | -2.51e-01 | -0.0511 |
463 | ZFHX3 | A002-C-114 | Human | Colorectum | FAP | 4.72e-21 | -2.94e-01 | -0.1561 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0007623 | Colorectum | AD | circadian rhythm | 72/3918 | 210/18723 | 4.50e-06 | 1.21e-04 | 72 |
GO:0048511 | Colorectum | AD | rhythmic process | 94/3918 | 298/18723 | 1.00e-05 | 2.34e-04 | 94 |
GO:0045785 | Colorectum | AD | positive regulation of cell adhesion | 122/3918 | 437/18723 | 2.65e-04 | 3.28e-03 | 122 |
GO:0042752 | Colorectum | AD | regulation of circadian rhythm | 40/3918 | 121/18723 | 1.24e-03 | 1.09e-02 | 40 |
GO:0071559 | Colorectum | AD | response to transforming growth factor beta | 74/3918 | 256/18723 | 1.45e-03 | 1.23e-02 | 74 |
GO:00076231 | Colorectum | SER | circadian rhythm | 54/2897 | 210/18723 | 7.98e-05 | 1.77e-03 | 54 |
GO:00457851 | Colorectum | SER | positive regulation of cell adhesion | 93/2897 | 437/18723 | 6.78e-04 | 9.04e-03 | 93 |
GO:00485111 | Colorectum | SER | rhythmic process | 65/2897 | 298/18723 | 2.18e-03 | 2.11e-02 | 65 |
GO:00427521 | Colorectum | SER | regulation of circadian rhythm | 30/2897 | 121/18723 | 5.03e-03 | 3.88e-02 | 30 |
GO:00076232 | Colorectum | MSS | circadian rhythm | 69/3467 | 210/18723 | 4.22e-07 | 1.67e-05 | 69 |
GO:00485112 | Colorectum | MSS | rhythmic process | 89/3467 | 298/18723 | 1.17e-06 | 3.96e-05 | 89 |
GO:00457852 | Colorectum | MSS | positive regulation of cell adhesion | 110/3467 | 437/18723 | 2.94e-04 | 3.87e-03 | 110 |
GO:00427522 | Colorectum | MSS | regulation of circadian rhythm | 38/3467 | 121/18723 | 4.33e-04 | 5.23e-03 | 38 |
GO:00076233 | Colorectum | FAP | circadian rhythm | 56/2622 | 210/18723 | 9.12e-07 | 4.14e-05 | 56 |
GO:00485113 | Colorectum | FAP | rhythmic process | 72/2622 | 298/18723 | 1.67e-06 | 6.99e-05 | 72 |
GO:00715591 | Colorectum | FAP | response to transforming growth factor beta | 63/2622 | 256/18723 | 3.82e-06 | 1.32e-04 | 63 |
GO:00457854 | Colorectum | FAP | positive regulation of cell adhesion | 92/2622 | 437/18723 | 3.09e-05 | 7.04e-04 | 92 |
GO:00427523 | Colorectum | FAP | regulation of circadian rhythm | 33/2622 | 121/18723 | 9.26e-05 | 1.59e-03 | 33 |
GO:0032922 | Colorectum | FAP | circadian regulation of gene expression | 18/2622 | 68/18723 | 4.83e-03 | 3.25e-02 | 18 |
GO:00485114 | Colorectum | CRC | rhythmic process | 64/2078 | 298/18723 | 1.43e-07 | 1.62e-05 | 64 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZFHX3 | SNV | Missense_Mutation | novel | c.9632N>A | p.Pro3211His | p.P3211H | Q15911 | protein_coding | deleterious_low_confidence(0.05) | benign(0.009) | TCGA-AA-3833-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZFHX3 | SNV | Missense_Mutation | c.2875N>T | p.Asp959Tyr | p.D959Y | Q15911 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-AA-3846-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZFHX3 | SNV | Missense_Mutation | novel | c.8147N>T | p.Cys2716Phe | p.C2716F | Q15911 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AA-3850-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ZFHX3 | SNV | Missense_Mutation | rs200701402 | c.8557N>A | p.Ala2853Thr | p.A2853T | Q15911 | protein_coding | tolerated(0.29) | benign(0.174) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZFHX3 | SNV | Missense_Mutation | novel | c.5827A>G | p.Asn1943Asp | p.N1943D | Q15911 | protein_coding | deleterious(0.01) | probably_damaging(0.978) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZFHX3 | SNV | Missense_Mutation | rs745989025 | c.8566G>A | p.Asp2856Asn | p.D2856N | Q15911 | protein_coding | tolerated(0.1) | probably_damaging(0.996) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZFHX3 | SNV | Missense_Mutation | novel | c.7201A>C | p.Thr2401Pro | p.T2401P | Q15911 | protein_coding | tolerated(0.09) | benign(0.04) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZFHX3 | SNV | Missense_Mutation | rs760400785 | c.3623N>T | p.Ser1208Leu | p.S1208L | Q15911 | protein_coding | tolerated(0.27) | benign(0.115) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ZFHX3 | SNV | Missense_Mutation | rs756319969 | c.184N>A | p.Ala62Thr | p.A62T | Q15911 | protein_coding | tolerated_low_confidence(0.2) | benign(0.023) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
ZFHX3 | SNV | Missense_Mutation | novel | c.1787N>C | p.Asn596Thr | p.N596T | Q15911 | protein_coding | deleterious(0.01) | possibly_damaging(0.719) | TCGA-AA-A01K-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | folinic | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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