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Gene: ZC3H14 |
Gene summary for ZC3H14 |
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Gene information | Species | Human | Gene symbol | ZC3H14 | Gene ID | 79882 |
Gene name | zinc finger CCCH-type containing 14 | |
Gene Alias | MRT56 | |
Cytomap | 14q31.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q6PJT7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79882 | ZC3H14 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.60e-10 | -5.13e-01 | 0.0155 |
79882 | ZC3H14 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.88e-03 | -4.74e-01 | -0.1808 |
79882 | ZC3H14 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.55e-07 | -3.31e-01 | -0.1464 |
79882 | ZC3H14 | HTA11_866_3004761011 | Human | Colorectum | AD | 5.06e-03 | -4.11e-01 | 0.096 |
79882 | ZC3H14 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.94e-08 | -3.80e-01 | 0.0674 |
79882 | ZC3H14 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.33e-05 | -3.26e-01 | 0.294 |
79882 | ZC3H14 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 4.88e-10 | -4.14e-01 | 0.3859 |
79882 | ZC3H14 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.70e-02 | -5.20e-01 | 0.2585 |
79882 | ZC3H14 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.11e-20 | -5.04e-01 | 0.3005 |
79882 | ZC3H14 | A015-C-203 | Human | Colorectum | FAP | 1.23e-19 | -3.45e-01 | -0.1294 |
79882 | ZC3H14 | A002-C-201 | Human | Colorectum | FAP | 1.16e-06 | -2.92e-01 | 0.0324 |
79882 | ZC3H14 | A001-C-108 | Human | Colorectum | FAP | 1.01e-10 | -2.20e-01 | -0.0272 |
79882 | ZC3H14 | A002-C-205 | Human | Colorectum | FAP | 2.09e-10 | -2.09e-01 | -0.1236 |
79882 | ZC3H14 | A001-C-104 | Human | Colorectum | FAP | 4.52e-03 | -2.12e-01 | 0.0184 |
79882 | ZC3H14 | A015-C-006 | Human | Colorectum | FAP | 2.12e-06 | -2.59e-01 | -0.0994 |
79882 | ZC3H14 | A015-C-106 | Human | Colorectum | FAP | 1.14e-10 | -2.58e-01 | -0.0511 |
79882 | ZC3H14 | A002-C-114 | Human | Colorectum | FAP | 4.26e-07 | -1.91e-01 | -0.1561 |
79882 | ZC3H14 | A015-C-104 | Human | Colorectum | FAP | 2.51e-20 | -1.98e-01 | -0.1899 |
79882 | ZC3H14 | A001-C-014 | Human | Colorectum | FAP | 4.41e-13 | -3.79e-01 | 0.0135 |
79882 | ZC3H14 | A002-C-016 | Human | Colorectum | FAP | 3.62e-18 | -3.36e-01 | 0.0521 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:1903311 | Colorectum | AD | regulation of mRNA metabolic process | 117/3918 | 288/18723 | 1.69e-14 | 4.23e-12 | 117 |
GO:0050684 | Colorectum | AD | regulation of mRNA processing | 61/3918 | 137/18723 | 4.23e-10 | 3.58e-08 | 61 |
GO:0006401 | Colorectum | AD | RNA catabolic process | 102/3918 | 278/18723 | 8.64e-10 | 6.76e-08 | 102 |
GO:0044270 | Colorectum | AD | cellular nitrogen compound catabolic process | 147/3918 | 451/18723 | 3.35e-09 | 2.23e-07 | 147 |
GO:0046700 | Colorectum | AD | heterocycle catabolic process | 145/3918 | 445/18723 | 4.37e-09 | 2.84e-07 | 145 |
GO:0006402 | Colorectum | AD | mRNA catabolic process | 87/3918 | 232/18723 | 4.40e-09 | 2.84e-07 | 87 |
GO:0034655 | Colorectum | AD | nucleobase-containing compound catabolic process | 133/3918 | 407/18723 | 1.56e-08 | 9.12e-07 | 133 |
GO:0019439 | Colorectum | AD | aromatic compound catabolic process | 146/3918 | 467/18723 | 7.48e-08 | 3.84e-06 | 146 |
GO:1901361 | Colorectum | AD | organic cyclic compound catabolic process | 153/3918 | 495/18723 | 8.23e-08 | 4.18e-06 | 153 |
GO:0061013 | Colorectum | AD | regulation of mRNA catabolic process | 64/3918 | 166/18723 | 1.44e-07 | 6.59e-06 | 64 |
GO:0043487 | Colorectum | AD | regulation of RNA stability | 63/3918 | 170/18723 | 9.17e-07 | 3.12e-05 | 63 |
GO:0043488 | Colorectum | AD | regulation of mRNA stability | 59/3918 | 158/18723 | 1.50e-06 | 4.66e-05 | 59 |
GO:1903312 | Colorectum | AD | negative regulation of mRNA metabolic process | 37/3918 | 92/18723 | 1.95e-05 | 4.01e-04 | 37 |
GO:0050686 | Colorectum | AD | negative regulation of mRNA processing | 13/3918 | 29/18723 | 3.26e-03 | 2.39e-02 | 13 |
GO:19033111 | Colorectum | SER | regulation of mRNA metabolic process | 78/2897 | 288/18723 | 2.61e-07 | 1.43e-05 | 78 |
GO:00506841 | Colorectum | SER | regulation of mRNA processing | 42/2897 | 137/18723 | 5.57e-06 | 2.01e-04 | 42 |
GO:00442701 | Colorectum | SER | cellular nitrogen compound catabolic process | 99/2897 | 451/18723 | 1.46e-04 | 2.86e-03 | 99 |
GO:00467001 | Colorectum | SER | heterocycle catabolic process | 97/2897 | 445/18723 | 2.20e-04 | 3.89e-03 | 97 |
GO:19013611 | Colorectum | SER | organic cyclic compound catabolic process | 104/2897 | 495/18723 | 5.46e-04 | 7.63e-03 | 104 |
GO:00346551 | Colorectum | SER | nucleobase-containing compound catabolic process | 88/2897 | 407/18723 | 5.53e-04 | 7.71e-03 | 88 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZC3H14 | insertion | Frame_Shift_Ins | novel | c.1580_1581insC | p.Gly530ArgfsTer13 | p.G530Rfs*13 | Q6PJT7 | protein_coding | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD | ||
ZC3H14 | SNV | Missense_Mutation | novel | c.424N>G | p.Asn142Asp | p.N142D | Q6PJT7 | protein_coding | tolerated(0.6) | benign(0.022) | TCGA-2Y-A9H7-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ZC3H14 | SNV | Missense_Mutation | novel | c.115N>T | p.Ala39Ser | p.A39S | Q6PJT7 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-RC-A7SK-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
ZC3H14 | SNV | Missense_Mutation | c.1130A>C | p.Gln377Pro | p.Q377P | Q6PJT7 | protein_coding | tolerated(0.08) | probably_damaging(0.988) | TCGA-UB-A7MB-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Targeted Molecular therapy | sorafenib | PD | |
ZC3H14 | SNV | Missense_Mutation | c.1132N>C | p.Lys378Gln | p.K378Q | Q6PJT7 | protein_coding | deleterious(0.02) | probably_damaging(0.912) | TCGA-55-7227-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | SD | |
ZC3H14 | SNV | Missense_Mutation | c.2142N>G | p.Phe714Leu | p.F714L | Q6PJT7 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-55-7726-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZC3H14 | SNV | Missense_Mutation | c.176N>G | p.Thr59Arg | p.T59R | Q6PJT7 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-67-4679-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZC3H14 | SNV | Missense_Mutation | c.1585C>T | p.Pro529Ser | p.P529S | Q6PJT7 | protein_coding | tolerated(0.51) | probably_damaging(0.943) | TCGA-75-5126-01 | Lung | lung adenocarcinoma | Female | Unknown | III/IV | Unknown | Unknown | SD | |
ZC3H14 | SNV | Missense_Mutation | novel | c.1377N>C | p.Met459Ile | p.M459I | Q6PJT7 | protein_coding | tolerated(0.27) | benign(0.005) | TCGA-86-6851-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZC3H14 | SNV | Missense_Mutation | c.364G>T | p.Ala122Ser | p.A122S | Q6PJT7 | protein_coding | tolerated(1) | benign(0) | TCGA-93-8067-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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