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Gene: ZBTB41 |
Gene summary for ZBTB41 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ZBTB41 | Gene ID | 360023 |
Gene name | zinc finger and BTB domain containing 41 | |
Gene Alias | FRBZ1 | |
Cytomap | 1q31.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q5SVQ8 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
360023 | ZBTB41 | HCC1_Meng | Human | Liver | HCC | 3.08e-40 | 8.88e-02 | 0.0246 |
360023 | ZBTB41 | HCC2_Meng | Human | Liver | HCC | 9.15e-19 | 1.59e-01 | 0.0107 |
360023 | ZBTB41 | HCC1 | Human | Liver | HCC | 9.07e-05 | 2.86e+00 | 0.5336 |
360023 | ZBTB41 | HCC2 | Human | Liver | HCC | 3.78e-11 | 2.86e+00 | 0.5341 |
360023 | ZBTB41 | S016 | Human | Liver | HCC | 5.37e-03 | 1.69e-01 | 0.2243 |
360023 | ZBTB41 | S027 | Human | Liver | HCC | 5.93e-04 | 4.50e-01 | 0.2446 |
360023 | ZBTB41 | S028 | Human | Liver | HCC | 2.21e-16 | 6.04e-01 | 0.2503 |
360023 | ZBTB41 | S029 | Human | Liver | HCC | 1.13e-10 | 5.71e-01 | 0.2581 |
360023 | ZBTB41 | male-WTA | Human | Thyroid | PTC | 6.60e-10 | 1.08e-01 | 0.1037 |
360023 | ZBTB41 | PTC01 | Human | Thyroid | PTC | 3.39e-04 | 1.15e-02 | 0.1899 |
360023 | ZBTB41 | PTC04 | Human | Thyroid | PTC | 4.46e-08 | 1.18e-01 | 0.1927 |
360023 | ZBTB41 | PTC05 | Human | Thyroid | PTC | 1.56e-04 | 3.07e-01 | 0.2065 |
360023 | ZBTB41 | PTC06 | Human | Thyroid | PTC | 6.50e-20 | 3.88e-01 | 0.2057 |
360023 | ZBTB41 | PTC07 | Human | Thyroid | PTC | 3.27e-26 | 2.43e-01 | 0.2044 |
360023 | ZBTB41 | ATC12 | Human | Thyroid | ATC | 5.05e-09 | 1.15e-01 | 0.34 |
360023 | ZBTB41 | ATC13 | Human | Thyroid | ATC | 7.67e-27 | 6.42e-01 | 0.34 |
360023 | ZBTB41 | ATC2 | Human | Thyroid | ATC | 1.88e-09 | 6.30e-01 | 0.34 |
360023 | ZBTB41 | ATC4 | Human | Thyroid | ATC | 2.68e-07 | 1.72e-01 | 0.34 |
360023 | ZBTB41 | ATC5 | Human | Thyroid | ATC | 4.30e-36 | 6.77e-01 | 0.34 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZBTB41 | SNV | Missense_Mutation | novel | c.850N>C | p.Asn284His | p.N284H | Q5SVQ8 | protein_coding | tolerated(0.19) | benign(0.037) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
ZBTB41 | SNV | Missense_Mutation | rs763513693 | c.667N>A | p.Glu223Lys | p.E223K | Q5SVQ8 | protein_coding | deleterious_low_confidence(0.02) | benign(0) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
ZBTB41 | SNV | Missense_Mutation | c.316N>A | p.Val106Ile | p.V106I | Q5SVQ8 | protein_coding | deleterious_low_confidence(0.02) | possibly_damaging(0.495) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD | |
ZBTB41 | SNV | Missense_Mutation | rs868581053 | c.2063N>A | p.Arg688Gln | p.R688Q | Q5SVQ8 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZBTB41 | SNV | Missense_Mutation | c.1805N>T | p.Arg602Ile | p.R602I | Q5SVQ8 | protein_coding | tolerated(0.29) | probably_damaging(0.999) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZBTB41 | SNV | Missense_Mutation | novel | c.2554G>T | p.Ala852Ser | p.A852S | Q5SVQ8 | protein_coding | tolerated_low_confidence(0.12) | benign(0.001) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
ZBTB41 | SNV | Missense_Mutation | c.529G>A | p.Glu177Lys | p.E177K | Q5SVQ8 | protein_coding | tolerated_low_confidence(0.18) | possibly_damaging(0.812) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD | |
ZBTB41 | SNV | Missense_Mutation | novel | c.813G>T | p.Gln271His | p.Q271H | Q5SVQ8 | protein_coding | deleterious(0.05) | benign(0.011) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ZBTB41 | SNV | Missense_Mutation | c.2659C>A | p.Leu887Ile | p.L887I | Q5SVQ8 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.987) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
ZBTB41 | SNV | Missense_Mutation | c.764G>T | p.Arg255Met | p.R255M | Q5SVQ8 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.839) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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