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Gene: WARS |
Gene summary for WARS |
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Gene information | Species | Human | Gene symbol | WARS | Gene ID | 7453 |
Gene name | tryptophanyl-tRNA synthetase 1 | |
Gene Alias | GAMMA-2 | |
Cytomap | 14q32.2 | |
Gene Type | protein-coding | GO ID | GO:0001525 | UniProtAcc | A0A024R6K8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7453 | WARS | CCI_1 | Human | Cervix | CC | 1.49e-06 | 7.16e-01 | 0.528 |
7453 | WARS | CCI_2 | Human | Cervix | CC | 5.24e-13 | 1.00e+00 | 0.5249 |
7453 | WARS | CCI_3 | Human | Cervix | CC | 3.64e-03 | 2.47e-01 | 0.516 |
7453 | WARS | Tumor | Human | Cervix | CC | 1.38e-77 | 1.17e+00 | 0.1241 |
7453 | WARS | sample1 | Human | Cervix | CC | 5.56e-55 | 1.38e+00 | 0.0959 |
7453 | WARS | sample3 | Human | Cervix | CC | 3.62e-86 | 1.22e+00 | 0.1387 |
7453 | WARS | T1 | Human | Cervix | CC | 1.19e-75 | 1.21e+00 | 0.0918 |
7453 | WARS | T2 | Human | Cervix | CC | 6.01e-03 | 2.08e-01 | 0.0709 |
7453 | WARS | T3 | Human | Cervix | CC | 1.41e-80 | 1.17e+00 | 0.1389 |
7453 | WARS | EEC-subject5 | Human | Endometrium | EEC | 1.87e-02 | 2.09e-01 | -0.249 |
7453 | WARS | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 8.45e-13 | 4.53e-01 | -0.1869 |
7453 | WARS | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 1.54e-14 | 5.10e-01 | -0.1875 |
7453 | WARS | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 3.13e-15 | 4.83e-01 | -0.1883 |
7453 | WARS | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 6.26e-05 | 1.11e-01 | -0.1934 |
7453 | WARS | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 8.11e-19 | 4.24e-01 | -0.1917 |
7453 | WARS | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 3.23e-15 | 4.37e-01 | -0.1916 |
7453 | WARS | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 2.62e-13 | 4.92e-01 | -0.1269 |
7453 | WARS | LZE2T | Human | Esophagus | ESCC | 3.43e-04 | 6.47e-01 | 0.082 |
7453 | WARS | LZE4T | Human | Esophagus | ESCC | 6.97e-10 | 2.45e-01 | 0.0811 |
7453 | WARS | LZE5T | Human | Esophagus | ESCC | 1.14e-04 | 3.75e-01 | 0.0514 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:014005313 | Esophagus | ESCC | mitochondrial gene expression | 93/8552 | 108/18723 | 1.96e-18 | 2.03e-16 | 93 |
GO:003254314 | Esophagus | ESCC | mitochondrial translation | 68/8552 | 76/18723 | 1.02e-15 | 6.86e-14 | 68 |
GO:00063992 | Esophagus | ESCC | tRNA metabolic process | 122/8552 | 179/18723 | 9.03e-10 | 2.19e-08 | 122 |
GO:00009592 | Esophagus | ESCC | mitochondrial RNA metabolic process | 39/8552 | 49/18723 | 1.20e-06 | 1.49e-05 | 39 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WARS | SNV | Missense_Mutation | rs773270850 | c.1282G>A | p.Gly428Ser | p.G428S | P23381 | protein_coding | deleterious(0.04) | probably_damaging(0.928) | TCGA-BR-7707-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
WARS | deletion | Frame_Shift_Del | novel | c.488delN | p.Gly163AlafsTer9 | p.G163Afs*9 | P23381 | protein_coding | TCGA-CG-5723-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
WARS | insertion | Frame_Shift_Ins | novel | c.865_866insGTCTACCACAGCAC | p.Phe289CysfsTer36 | p.F289Cfs*36 | P23381 | protein_coding | TCGA-EL-A3H1-01 | Thyroid | thyroid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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