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Gene: USP22 |
Gene summary for USP22 |
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Gene information | Species | Human | Gene symbol | USP22 | Gene ID | 23326 |
Gene name | ubiquitin specific peptidase 22 | |
Gene Alias | USP3L | |
Cytomap | 17p11.2 | |
Gene Type | protein-coding | GO ID | GO:0000278 | UniProtAcc | Q9UPT9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23326 | USP22 | A001-C-207 | Human | Colorectum | FAP | 3.22e-02 | -1.43e-01 | 0.1278 |
23326 | USP22 | A015-C-203 | Human | Colorectum | FAP | 1.78e-18 | -3.02e-01 | -0.1294 |
23326 | USP22 | A015-C-204 | Human | Colorectum | FAP | 1.83e-04 | -1.71e-01 | -0.0228 |
23326 | USP22 | A014-C-040 | Human | Colorectum | FAP | 1.89e-02 | -1.47e-01 | -0.1184 |
23326 | USP22 | A002-C-201 | Human | Colorectum | FAP | 3.28e-08 | -1.16e-01 | 0.0324 |
23326 | USP22 | A001-C-119 | Human | Colorectum | FAP | 4.21e-03 | -1.91e-01 | -0.1557 |
23326 | USP22 | A001-C-108 | Human | Colorectum | FAP | 1.79e-09 | -1.76e-01 | -0.0272 |
23326 | USP22 | A002-C-205 | Human | Colorectum | FAP | 1.49e-16 | -2.79e-01 | -0.1236 |
23326 | USP22 | A015-C-006 | Human | Colorectum | FAP | 4.93e-10 | -2.85e-01 | -0.0994 |
23326 | USP22 | A015-C-106 | Human | Colorectum | FAP | 3.22e-05 | -8.56e-02 | -0.0511 |
23326 | USP22 | A002-C-114 | Human | Colorectum | FAP | 1.70e-11 | -1.92e-01 | -0.1561 |
23326 | USP22 | A015-C-104 | Human | Colorectum | FAP | 2.15e-17 | -1.56e-01 | -0.1899 |
23326 | USP22 | A001-C-014 | Human | Colorectum | FAP | 6.59e-08 | -2.27e-01 | 0.0135 |
23326 | USP22 | A002-C-016 | Human | Colorectum | FAP | 3.16e-09 | -2.16e-01 | 0.0521 |
23326 | USP22 | A015-C-002 | Human | Colorectum | FAP | 2.79e-08 | -2.94e-01 | -0.0763 |
23326 | USP22 | A001-C-203 | Human | Colorectum | FAP | 1.04e-05 | -9.68e-02 | -0.0481 |
23326 | USP22 | A002-C-116 | Human | Colorectum | FAP | 2.37e-19 | -2.38e-01 | -0.0452 |
23326 | USP22 | A014-C-008 | Human | Colorectum | FAP | 9.08e-11 | -3.53e-01 | -0.191 |
23326 | USP22 | A018-E-020 | Human | Colorectum | FAP | 9.70e-12 | -1.62e-01 | -0.2034 |
23326 | USP22 | F034 | Human | Colorectum | FAP | 8.84e-10 | -1.70e-01 | -0.0665 |
Page: 1 2 3 4 5 6 7 8 9 10 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00165701 | Colorectum | FAP | histone modification | 94/2622 | 463/18723 | 1.06e-04 | 1.76e-03 | 94 |
GO:00457872 | Colorectum | FAP | positive regulation of cell cycle | 66/2622 | 313/18723 | 3.66e-04 | 4.63e-03 | 66 |
GO:00073462 | Colorectum | FAP | regulation of mitotic cell cycle | 85/2622 | 457/18723 | 3.41e-03 | 2.48e-02 | 85 |
GO:00165741 | Colorectum | FAP | histone ubiquitination | 14/2622 | 47/18723 | 3.95e-03 | 2.75e-02 | 14 |
GO:00459311 | Colorectum | FAP | positive regulation of mitotic cell cycle | 27/2622 | 121/18723 | 8.64e-03 | 4.98e-02 | 27 |
GO:00457873 | Colorectum | CRC | positive regulation of cell cycle | 55/2078 | 313/18723 | 3.76e-04 | 5.57e-03 | 55 |
GO:00165702 | Colorectum | CRC | histone modification | 75/2078 | 463/18723 | 4.95e-04 | 7.06e-03 | 75 |
GO:00459312 | Colorectum | CRC | positive regulation of mitotic cell cycle | 25/2078 | 121/18723 | 1.54e-03 | 1.63e-02 | 25 |
GO:00182057 | Esophagus | HGIN | peptidyl-lysine modification | 88/2587 | 376/18723 | 2.99e-07 | 1.39e-05 | 88 |
GO:000734610 | Esophagus | HGIN | regulation of mitotic cell cycle | 98/2587 | 457/18723 | 4.39e-06 | 1.42e-04 | 98 |
GO:00165708 | Esophagus | HGIN | histone modification | 92/2587 | 463/18723 | 1.70e-04 | 3.30e-03 | 92 |
GO:00165747 | Esophagus | HGIN | histone ubiquitination | 16/2587 | 47/18723 | 3.61e-04 | 5.68e-03 | 16 |
GO:00064735 | Esophagus | HGIN | protein acetylation | 45/2587 | 201/18723 | 6.17e-04 | 8.58e-03 | 45 |
GO:00183945 | Esophagus | HGIN | peptidyl-lysine acetylation | 39/2587 | 169/18723 | 7.46e-04 | 9.90e-03 | 39 |
GO:00435435 | Esophagus | HGIN | protein acylation | 51/2587 | 243/18723 | 1.33e-03 | 1.57e-02 | 51 |
GO:00439675 | Esophagus | HGIN | histone H4 acetylation | 19/2587 | 67/18723 | 1.39e-03 | 1.63e-02 | 19 |
GO:00064755 | Esophagus | HGIN | internal protein amino acid acetylation | 36/2587 | 160/18723 | 1.87e-03 | 2.01e-02 | 36 |
GO:00183935 | Esophagus | HGIN | internal peptidyl-lysine acetylation | 35/2587 | 158/18723 | 2.82e-03 | 2.75e-02 | 35 |
GO:004593110 | Esophagus | HGIN | positive regulation of mitotic cell cycle | 28/2587 | 121/18723 | 3.72e-03 | 3.39e-02 | 28 |
GO:00706463 | Esophagus | HGIN | protein modification by small protein removal | 34/2587 | 157/18723 | 4.68e-03 | 4.02e-02 | 34 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
USP22 | SNV | Missense_Mutation | rs372666473 | c.1082N>T | p.Thr361Met | p.T361M | Q9UPT9 | protein_coding | deleterious(0) | possibly_damaging(0.803) | TCGA-56-8626-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
USP22 | SNV | Missense_Mutation | novel | c.851G>A | p.Gly284Glu | p.G284E | Q9UPT9 | protein_coding | tolerated(0.17) | benign(0.034) | TCGA-85-8352-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
USP22 | SNV | Missense_Mutation | novel | c.604G>T | p.Asp202Tyr | p.D202Y | Q9UPT9 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-BA-A6DJ-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
USP22 | SNV | Missense_Mutation | novel | c.382G>A | p.Ala128Thr | p.A128T | Q9UPT9 | protein_coding | deleterious(0.04) | benign(0.284) | TCGA-CV-5434-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD |
USP22 | SNV | Missense_Mutation | novel | c.1211T>C | p.Val404Ala | p.V404A | Q9UPT9 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-D6-6516-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
USP22 | SNV | Missense_Mutation | novel | c.1444N>C | p.Ser482Arg | p.S482R | Q9UPT9 | protein_coding | deleterious(0.02) | possibly_damaging(0.653) | TCGA-BR-4280-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
USP22 | SNV | Missense_Mutation | c.639G>A | p.Met213Ile | p.M213I | Q9UPT9 | protein_coding | tolerated(0.31) | benign(0.038) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
USP22 | SNV | Missense_Mutation | rs768637952 | c.1255C>T | p.Arg419Trp | p.R419W | Q9UPT9 | protein_coding | deleterious(0) | probably_damaging(0.953) | TCGA-BR-4368-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
USP22 | SNV | Missense_Mutation | c.526C>T | p.Arg176Cys | p.R176C | Q9UPT9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BR-7851-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
USP22 | SNV | Missense_Mutation | rs761846968 | c.293N>A | p.Arg98Gln | p.R98Q | Q9UPT9 | protein_coding | tolerated(0.68) | benign(0.007) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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