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Gene: UBN2 |
Gene summary for UBN2 |
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Gene information | Species | Human | Gene symbol | UBN2 | Gene ID | 254048 |
Gene name | ubinuclein 2 | |
Gene Alias | UBN2 | |
Cytomap | 7q34 | |
Gene Type | protein-coding | GO ID | GO:0006323 | UniProtAcc | Q6ZU65 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
254048 | UBN2 | NAFLD1 | Human | Liver | NAFLD | 4.90e-02 | 4.14e-01 | -0.04 |
254048 | UBN2 | HCC1_Meng | Human | Liver | HCC | 2.70e-31 | -2.98e-02 | 0.0246 |
254048 | UBN2 | HCC2_Meng | Human | Liver | HCC | 3.64e-20 | 9.40e-02 | 0.0107 |
254048 | UBN2 | HCC1 | Human | Liver | HCC | 6.67e-09 | 3.20e+00 | 0.5336 |
254048 | UBN2 | HCC2 | Human | Liver | HCC | 1.18e-25 | 3.74e+00 | 0.5341 |
254048 | UBN2 | HCC5 | Human | Liver | HCC | 5.02e-17 | 2.63e+00 | 0.4932 |
254048 | UBN2 | S015 | Human | Liver | HCC | 1.36e-04 | 4.23e-01 | 0.2375 |
254048 | UBN2 | S028 | Human | Liver | HCC | 3.78e-03 | 3.38e-01 | 0.2503 |
254048 | UBN2 | RNA-P10T2-P10T2-1 | Human | Lung | AAH | 7.31e-03 | 5.43e-01 | -0.1271 |
254048 | UBN2 | RNA-P17T-P17T-2 | Human | Lung | IAC | 2.13e-03 | 4.52e-01 | 0.3371 |
254048 | UBN2 | RNA-P17T-P17T-4 | Human | Lung | IAC | 1.48e-03 | 4.42e-01 | 0.343 |
254048 | UBN2 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 1.70e-10 | 4.53e-01 | -0.2116 |
254048 | UBN2 | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 7.48e-05 | 5.12e-01 | -0.1941 |
254048 | UBN2 | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 7.22e-04 | 3.91e-01 | -0.2107 |
254048 | UBN2 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 2.81e-06 | 3.83e-01 | -0.2119 |
254048 | UBN2 | RNA-P3T-P3T-4 | Human | Lung | IAC | 2.14e-03 | 3.00e-01 | 0.1859 |
254048 | UBN2 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 8.58e-08 | 2.87e-01 | -0.0166 |
254048 | UBN2 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 7.32e-11 | 3.46e-01 | -0.0132 |
254048 | UBN2 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 3.79e-16 | 4.49e-01 | -0.013 |
254048 | UBN2 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 1.16e-09 | 3.43e-01 | -0.0121 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00063255 | Liver | NAFLD | chromatin organization | 64/1882 | 409/18723 | 2.31e-04 | 3.89e-03 | 64 |
GO:000632511 | Liver | HCC | chromatin organization | 206/7958 | 409/18723 | 7.23e-04 | 4.41e-03 | 206 |
GO:00063256 | Lung | IAC | chromatin organization | 69/2061 | 409/18723 | 2.01e-04 | 3.53e-03 | 69 |
GO:000632512 | Lung | AIS | chromatin organization | 62/1849 | 409/18723 | 4.24e-04 | 7.29e-03 | 62 |
GO:000632520 | Thyroid | PTC | chromatin organization | 183/5968 | 409/18723 | 2.55e-08 | 5.70e-07 | 183 |
GO:00063385 | Thyroid | PTC | chromatin remodeling | 106/5968 | 255/18723 | 6.56e-04 | 4.13e-03 | 106 |
GO:0006325110 | Thyroid | ATC | chromatin organization | 189/6293 | 409/18723 | 6.40e-08 | 1.13e-06 | 189 |
GO:000633813 | Thyroid | ATC | chromatin remodeling | 109/6293 | 255/18723 | 1.38e-03 | 7.15e-03 | 109 |
GO:00718242 | Thyroid | ATC | protein-DNA complex subunit organization | 103/6293 | 241/18723 | 1.84e-03 | 9.03e-03 | 103 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UBN2 | SNV | Missense_Mutation | c.2043N>G | p.Ile681Met | p.I681M | Q6ZU65 | protein_coding | tolerated(0.2) | probably_damaging(0.991) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
UBN2 | SNV | Missense_Mutation | rs370784134 | c.2765N>T | p.Ser922Leu | p.S922L | Q6ZU65 | protein_coding | tolerated_low_confidence(0.06) | benign(0.022) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
UBN2 | SNV | Missense_Mutation | novel | c.1505N>A | p.Arg502His | p.R502H | Q6ZU65 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
UBN2 | SNV | Missense_Mutation | rs746848105 | c.739N>T | p.Arg247Cys | p.R247C | Q6ZU65 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-D1-A16X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UBN2 | SNV | Missense_Mutation | novel | c.531N>C | p.Glu177Asp | p.E177D | Q6ZU65 | protein_coding | deleterious(0.01) | probably_damaging(0.956) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UBN2 | SNV | Missense_Mutation | novel | c.2978N>A | p.Ser993Tyr | p.S993Y | Q6ZU65 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.896) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UBN2 | SNV | Missense_Mutation | rs368430654 | c.1129N>A | p.Gly377Ser | p.G377S | Q6ZU65 | protein_coding | tolerated(0.85) | benign(0) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UBN2 | SNV | Missense_Mutation | novel | c.1443N>T | p.Gln481His | p.Q481H | Q6ZU65 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UBN2 | SNV | Missense_Mutation | novel | c.3816N>T | p.Glu1272Asp | p.E1272D | Q6ZU65 | protein_coding | tolerated_low_confidence(0.05) | probably_damaging(0.97) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UBN2 | SNV | Missense_Mutation | novel | c.1919N>A | p.Ser640Tyr | p.S640Y | Q6ZU65 | protein_coding | deleterious(0) | possibly_damaging(0.832) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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