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Gene: UBC |
Gene summary for UBC |
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Gene information | Species | Human | Gene symbol | UBC | Gene ID | 7316 |
Gene name | ubiquitin C | |
Gene Alias | HMG20 | |
Cytomap | 12q24.31 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | P0CG48 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7316 | UBC | GSM4909277 | Human | Breast | Precancer | 2.76e-09 | 6.44e-01 | 0.0177 |
7316 | UBC | GSM4909285 | Human | Breast | IDC | 1.08e-15 | -3.83e-01 | 0.21 |
7316 | UBC | GSM4909286 | Human | Breast | IDC | 5.94e-32 | -5.28e-01 | 0.1081 |
7316 | UBC | GSM4909287 | Human | Breast | IDC | 6.69e-03 | 1.34e-01 | 0.2057 |
7316 | UBC | GSM4909290 | Human | Breast | IDC | 3.26e-09 | -4.17e-01 | 0.2096 |
7316 | UBC | GSM4909296 | Human | Breast | IDC | 3.20e-17 | -5.76e-01 | 0.1524 |
7316 | UBC | GSM4909297 | Human | Breast | IDC | 1.84e-06 | 1.25e-02 | 0.1517 |
7316 | UBC | GSM4909298 | Human | Breast | IDC | 4.52e-20 | -4.35e-01 | 0.1551 |
7316 | UBC | GSM4909301 | Human | Breast | IDC | 1.24e-05 | -3.48e-01 | 0.1577 |
7316 | UBC | GSM4909307 | Human | Breast | IDC | 3.88e-14 | -5.28e-01 | 0.1569 |
7316 | UBC | GSM4909309 | Human | Breast | IDC | 3.25e-07 | -4.20e-01 | 0.0483 |
7316 | UBC | GSM4909311 | Human | Breast | IDC | 2.76e-21 | -3.87e-01 | 0.1534 |
7316 | UBC | GSM4909317 | Human | Breast | IDC | 2.50e-04 | 2.35e-01 | 0.1355 |
7316 | UBC | GSM4909319 | Human | Breast | IDC | 8.14e-29 | 6.71e-02 | 0.1563 |
7316 | UBC | GSM4909320 | Human | Breast | IDC | 5.85e-06 | -5.03e-01 | 0.1575 |
7316 | UBC | GSM4909321 | Human | Breast | IDC | 1.97e-28 | 4.17e-01 | 0.1559 |
7316 | UBC | ctrl6 | Human | Breast | Precancer | 2.59e-21 | 5.27e-01 | -0.0061 |
7316 | UBC | brca1 | Human | Breast | Precancer | 7.36e-03 | 1.19e-01 | -0.0338 |
7316 | UBC | brca2 | Human | Breast | Precancer | 2.37e-05 | 7.28e-02 | -0.024 |
7316 | UBC | brca3 | Human | Breast | Precancer | 1.03e-15 | 2.62e-01 | -0.0263 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006091 | Colorectum | AD | generation of precursor metabolites and energy | 209/3918 | 490/18723 | 3.17e-28 | 6.61e-25 | 209 |
GO:0015980 | Colorectum | AD | energy derivation by oxidation of organic compounds | 143/3918 | 318/18723 | 2.78e-22 | 2.49e-19 | 143 |
GO:0022411 | Colorectum | AD | cellular component disassembly | 147/3918 | 443/18723 | 8.53e-10 | 6.76e-08 | 147 |
GO:0016236 | Colorectum | AD | macroautophagy | 103/3918 | 291/18723 | 6.76e-09 | 4.15e-07 | 103 |
GO:0032984 | Colorectum | AD | protein-containing complex disassembly | 81/3918 | 224/18723 | 9.41e-08 | 4.65e-06 | 81 |
GO:0016050 | Colorectum | AD | vesicle organization | 101/3918 | 300/18723 | 1.65e-07 | 7.17e-06 | 101 |
GO:0043467 | Colorectum | AD | regulation of generation of precursor metabolites and energy | 49/3918 | 130/18723 | 8.33e-06 | 1.99e-04 | 49 |
GO:0019318 | Colorectum | AD | hexose metabolic process | 77/3918 | 237/18723 | 1.96e-05 | 4.01e-04 | 77 |
GO:0044262 | Colorectum | AD | cellular carbohydrate metabolic process | 87/3918 | 283/18723 | 6.00e-05 | 1.01e-03 | 87 |
GO:0005996 | Colorectum | AD | monosaccharide metabolic process | 80/3918 | 257/18723 | 7.31e-05 | 1.17e-03 | 80 |
GO:0006006 | Colorectum | AD | glucose metabolic process | 62/3918 | 196/18723 | 2.76e-04 | 3.39e-03 | 62 |
GO:0006109 | Colorectum | AD | regulation of carbohydrate metabolic process | 55/3918 | 178/18723 | 1.10e-03 | 1.01e-02 | 55 |
GO:0062012 | Colorectum | AD | regulation of small molecule metabolic process | 93/3918 | 334/18723 | 1.46e-03 | 1.24e-02 | 93 |
GO:0048284 | Colorectum | AD | organelle fusion | 42/3918 | 141/18723 | 8.04e-03 | 4.73e-02 | 42 |
GO:00060912 | Colorectum | MSS | generation of precursor metabolites and energy | 186/3467 | 490/18723 | 1.14e-24 | 2.15e-21 | 186 |
GO:00159802 | Colorectum | MSS | energy derivation by oxidation of organic compounds | 131/3467 | 318/18723 | 2.60e-21 | 2.70e-18 | 131 |
GO:00224112 | Colorectum | MSS | cellular component disassembly | 130/3467 | 443/18723 | 1.44e-08 | 8.46e-07 | 130 |
GO:00162362 | Colorectum | MSS | macroautophagy | 93/3467 | 291/18723 | 2.08e-08 | 1.17e-06 | 93 |
GO:00160502 | Colorectum | MSS | vesicle organization | 93/3467 | 300/18723 | 1.04e-07 | 4.97e-06 | 93 |
GO:00434672 | Colorectum | MSS | regulation of generation of precursor metabolites and energy | 47/3467 | 130/18723 | 1.47e-06 | 4.85e-05 | 47 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501218 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0502216 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0513118 | Breast | Precancer | Shigellosis | 44/684 | 247/8465 | 3.91e-07 | 6.86e-06 | 5.26e-06 | 44 |
hsa0516718 | Breast | Precancer | Kaposi sarcoma-associated herpesvirus infection | 36/684 | 194/8465 | 1.68e-06 | 2.53e-05 | 1.94e-05 | 36 |
hsa0413716 | Breast | Precancer | Mitophagy - animal | 15/684 | 72/8465 | 5.22e-04 | 3.93e-03 | 3.01e-03 | 15 |
hsa0501219 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0502217 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0513119 | Breast | Precancer | Shigellosis | 44/684 | 247/8465 | 3.91e-07 | 6.86e-06 | 5.26e-06 | 44 |
hsa0516719 | Breast | Precancer | Kaposi sarcoma-associated herpesvirus infection | 36/684 | 194/8465 | 1.68e-06 | 2.53e-05 | 1.94e-05 | 36 |
hsa0413717 | Breast | Precancer | Mitophagy - animal | 15/684 | 72/8465 | 5.22e-04 | 3.93e-03 | 3.01e-03 | 15 |
hsa0501224 | Breast | IDC | Parkinson disease | 107/867 | 266/8465 | 2.57e-39 | 8.36e-37 | 6.26e-37 | 107 |
hsa0502223 | Breast | IDC | Pathways of neurodegeneration - multiple diseases | 116/867 | 476/8465 | 3.63e-20 | 1.18e-18 | 8.82e-19 | 116 |
hsa0513124 | Breast | IDC | Shigellosis | 47/867 | 247/8465 | 1.78e-05 | 2.00e-04 | 1.49e-04 | 47 |
hsa0516723 | Breast | IDC | Kaposi sarcoma-associated herpesvirus infection | 38/867 | 194/8465 | 5.87e-05 | 5.96e-04 | 4.46e-04 | 38 |
hsa0413723 | Breast | IDC | Mitophagy - animal | 17/867 | 72/8465 | 7.61e-04 | 6.04e-03 | 4.52e-03 | 17 |
hsa0501234 | Breast | IDC | Parkinson disease | 107/867 | 266/8465 | 2.57e-39 | 8.36e-37 | 6.26e-37 | 107 |
hsa0502233 | Breast | IDC | Pathways of neurodegeneration - multiple diseases | 116/867 | 476/8465 | 3.63e-20 | 1.18e-18 | 8.82e-19 | 116 |
hsa0513134 | Breast | IDC | Shigellosis | 47/867 | 247/8465 | 1.78e-05 | 2.00e-04 | 1.49e-04 | 47 |
hsa0516733 | Breast | IDC | Kaposi sarcoma-associated herpesvirus infection | 38/867 | 194/8465 | 5.87e-05 | 5.96e-04 | 4.46e-04 | 38 |
hsa0413733 | Breast | IDC | Mitophagy - animal | 17/867 | 72/8465 | 7.61e-04 | 6.04e-03 | 4.52e-03 | 17 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UBC | SNV | Missense_Mutation | novel | c.576G>T | p.Gln192His | p.Q192H | P0CG48 | protein_coding | deleterious(0.03) | possibly_damaging(0.492) | TCGA-90-7964-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
UBC | SNV | Missense_Mutation | novel | c.1639N>A | p.Leu547Ile | p.L547I | P0CG48 | protein_coding | tolerated(0.17) | probably_damaging(0.999) | TCGA-O2-A52N-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
UBC | SNV | Missense_Mutation | novel | c.130N>T | p.Ile44Phe | p.I44F | P0CG48 | protein_coding | tolerated(0.1) | probably_damaging(0.981) | TCGA-O2-A5IB-01 | Lung | lung squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
UBC | insertion | In_Frame_Ins | novel | c.506_508dupTGG | p.Val169dup | p.V169dup | P0CG48 | protein_coding | TCGA-55-8508-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | CR | ||
UBC | insertion | Frame_Shift_Ins | novel | c.904dupA | p.Arg302LysfsTer14 | p.R302Kfs*14 | P0CG48 | protein_coding | TCGA-78-7149-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | ||
UBC | SNV | Missense_Mutation | novel | c.730G>C | p.Glu244Gln | p.E244Q | P0CG48 | protein_coding | tolerated(0.06) | possibly_damaging(0.703) | TCGA-CR-7374-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
UBC | SNV | Missense_Mutation | novel | c.351G>C | p.Gln117His | p.Q117H | P0CG48 | protein_coding | deleterious(0) | possibly_damaging(0.819) | TCGA-CV-7414-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
UBC | SNV | Missense_Mutation | novel | c.94G>C | p.Asp32His | p.D32H | P0CG48 | protein_coding | deleterious(0.02) | probably_damaging(0.987) | TCGA-CV-7427-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
UBC | SNV | Missense_Mutation | novel | c.779A>G | p.Asp260Gly | p.D260G | P0CG48 | protein_coding | deleterious(0.01) | possibly_damaging(0.807) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
UBC | SNV | Missense_Mutation | c.718N>G | p.Thr240Ala | p.T240A | P0CG48 | protein_coding | deleterious(0.04) | benign(0.262) | TCGA-BR-4362-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7316 | UBC | KINASE, TRANSCRIPTION FACTOR | PMID25553724-Compound-US20130237529 35 | |||
7316 | UBC | KINASE, TRANSCRIPTION FACTOR | PMID25553724-Compound-US20130237529 36 |
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