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Gene: UBA2 |
Gene summary for UBA2 |
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Gene information | Species | Human | Gene symbol | UBA2 | Gene ID | 10054 |
Gene name | ubiquitin like modifier activating enzyme 2 | |
Gene Alias | ARX | |
Cytomap | 19q13.11 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q9UBT2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10054 | UBA2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 4.98e-03 | 3.73e-01 | -0.0811 |
10054 | UBA2 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.00e-04 | 3.30e-01 | -0.1954 |
10054 | UBA2 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 7.73e-04 | 1.00e+00 | 0.3487 |
10054 | UBA2 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 7.57e-05 | 4.93e-01 | 0.281 |
10054 | UBA2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.25e-02 | 4.87e-01 | 0.3859 |
10054 | UBA2 | A015-C-203 | Human | Colorectum | FAP | 9.97e-15 | -2.73e-01 | -0.1294 |
10054 | UBA2 | A014-C-040 | Human | Colorectum | FAP | 4.94e-03 | -4.29e-01 | -0.1184 |
10054 | UBA2 | A002-C-201 | Human | Colorectum | FAP | 3.66e-05 | -2.49e-01 | 0.0324 |
10054 | UBA2 | A001-C-108 | Human | Colorectum | FAP | 1.72e-08 | -1.49e-01 | -0.0272 |
10054 | UBA2 | A002-C-205 | Human | Colorectum | FAP | 4.69e-08 | -2.46e-01 | -0.1236 |
10054 | UBA2 | A015-C-006 | Human | Colorectum | FAP | 1.38e-05 | -1.26e-01 | -0.0994 |
10054 | UBA2 | A015-C-106 | Human | Colorectum | FAP | 6.80e-06 | -1.98e-01 | -0.0511 |
10054 | UBA2 | A002-C-114 | Human | Colorectum | FAP | 3.53e-07 | -2.94e-01 | -0.1561 |
10054 | UBA2 | A015-C-104 | Human | Colorectum | FAP | 7.37e-16 | -2.85e-01 | -0.1899 |
10054 | UBA2 | A001-C-014 | Human | Colorectum | FAP | 5.01e-08 | -2.46e-01 | 0.0135 |
10054 | UBA2 | A002-C-016 | Human | Colorectum | FAP | 1.34e-11 | -2.67e-01 | 0.0521 |
10054 | UBA2 | A015-C-002 | Human | Colorectum | FAP | 3.62e-03 | -2.86e-01 | -0.0763 |
10054 | UBA2 | A001-C-203 | Human | Colorectum | FAP | 6.58e-07 | -2.21e-01 | -0.0481 |
10054 | UBA2 | A002-C-116 | Human | Colorectum | FAP | 6.56e-16 | -2.33e-01 | -0.0452 |
10054 | UBA2 | A014-C-008 | Human | Colorectum | FAP | 1.25e-04 | -2.74e-01 | -0.191 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:1903320 | Colorectum | AD | regulation of protein modification by small protein conjugation or removal | 86/3918 | 242/18723 | 9.43e-08 | 4.65e-06 | 86 |
GO:19033202 | Colorectum | MSS | regulation of protein modification by small protein conjugation or removal | 82/3467 | 242/18723 | 7.49e-09 | 4.63e-07 | 82 |
GO:19033203 | Colorectum | MSI-H | regulation of protein modification by small protein conjugation or removal | 43/1319 | 242/18723 | 1.60e-08 | 1.85e-06 | 43 |
GO:19033204 | Colorectum | FAP | regulation of protein modification by small protein conjugation or removal | 61/2622 | 242/18723 | 2.36e-06 | 9.21e-05 | 61 |
GO:19033205 | Colorectum | CRC | regulation of protein modification by small protein conjugation or removal | 51/2078 | 242/18723 | 4.55e-06 | 1.87e-04 | 51 |
GO:190332027 | Esophagus | HGIN | regulation of protein modification by small protein conjugation or removal | 78/2587 | 242/18723 | 1.40e-13 | 2.26e-11 | 78 |
GO:00182057 | Esophagus | HGIN | peptidyl-lysine modification | 88/2587 | 376/18723 | 2.99e-07 | 1.39e-05 | 88 |
GO:00169254 | Esophagus | HGIN | protein sumoylation | 18/2587 | 53/18723 | 1.64e-04 | 3.19e-03 | 18 |
GO:19033228 | Esophagus | HGIN | positive regulation of protein modification by small protein conjugation or removal | 35/2587 | 138/18723 | 2.11e-04 | 3.88e-03 | 35 |
GO:0033233 | Esophagus | HGIN | regulation of protein sumoylation | 9/2587 | 25/18723 | 4.57e-03 | 3.96e-02 | 9 |
GO:1903320111 | Esophagus | ESCC | regulation of protein modification by small protein conjugation or removal | 181/8552 | 242/18723 | 1.80e-20 | 2.60e-18 | 181 |
GO:001820514 | Esophagus | ESCC | peptidyl-lysine modification | 259/8552 | 376/18723 | 3.90e-20 | 5.26e-18 | 259 |
GO:190332216 | Esophagus | ESCC | positive regulation of protein modification by small protein conjugation or removal | 99/8552 | 138/18723 | 4.39e-10 | 1.16e-08 | 99 |
GO:001692512 | Esophagus | ESCC | protein sumoylation | 41/8552 | 53/18723 | 2.49e-06 | 2.86e-05 | 41 |
GO:00332331 | Esophagus | ESCC | regulation of protein sumoylation | 18/8552 | 25/18723 | 7.04e-03 | 2.56e-02 | 18 |
GO:0033235 | Esophagus | ESCC | positive regulation of protein sumoylation | 10/8552 | 12/18723 | 8.94e-03 | 3.12e-02 | 10 |
GO:0018205 | Liver | NAFLD | peptidyl-lysine modification | 65/1882 | 376/18723 | 9.42e-06 | 3.02e-04 | 65 |
GO:19033207 | Liver | NAFLD | regulation of protein modification by small protein conjugation or removal | 44/1882 | 242/18723 | 7.53e-05 | 1.56e-03 | 44 |
GO:190332012 | Liver | Cirrhotic | regulation of protein modification by small protein conjugation or removal | 105/4634 | 242/18723 | 1.43e-10 | 7.43e-09 | 105 |
GO:00182051 | Liver | Cirrhotic | peptidyl-lysine modification | 134/4634 | 376/18723 | 1.29e-06 | 2.59e-05 | 134 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04120 | Colorectum | AD | Ubiquitin mediated proteolysis | 58/2092 | 142/8465 | 1.46e-05 | 1.53e-04 | 9.76e-05 | 58 |
hsa041201 | Colorectum | AD | Ubiquitin mediated proteolysis | 58/2092 | 142/8465 | 1.46e-05 | 1.53e-04 | 9.76e-05 | 58 |
hsa041204 | Colorectum | MSS | Ubiquitin mediated proteolysis | 55/1875 | 142/8465 | 5.02e-06 | 6.00e-05 | 3.68e-05 | 55 |
hsa041205 | Colorectum | MSS | Ubiquitin mediated proteolysis | 55/1875 | 142/8465 | 5.02e-06 | 6.00e-05 | 3.68e-05 | 55 |
hsa041206 | Colorectum | FAP | Ubiquitin mediated proteolysis | 51/1404 | 142/8465 | 1.55e-08 | 5.84e-07 | 3.55e-07 | 51 |
hsa041207 | Colorectum | FAP | Ubiquitin mediated proteolysis | 51/1404 | 142/8465 | 1.55e-08 | 5.84e-07 | 3.55e-07 | 51 |
hsa041208 | Colorectum | CRC | Ubiquitin mediated proteolysis | 42/1091 | 142/8465 | 9.98e-08 | 6.67e-06 | 4.52e-06 | 42 |
hsa041209 | Colorectum | CRC | Ubiquitin mediated proteolysis | 42/1091 | 142/8465 | 9.98e-08 | 6.67e-06 | 4.52e-06 | 42 |
hsa0412026 | Esophagus | HGIN | Ubiquitin mediated proteolysis | 49/1383 | 142/8465 | 7.78e-08 | 1.33e-06 | 1.06e-06 | 49 |
hsa04120111 | Esophagus | HGIN | Ubiquitin mediated proteolysis | 49/1383 | 142/8465 | 7.78e-08 | 1.33e-06 | 1.06e-06 | 49 |
hsa0412027 | Esophagus | ESCC | Ubiquitin mediated proteolysis | 122/4205 | 142/8465 | 6.53e-20 | 7.29e-18 | 3.74e-18 | 122 |
hsa0412036 | Esophagus | ESCC | Ubiquitin mediated proteolysis | 122/4205 | 142/8465 | 6.53e-20 | 7.29e-18 | 3.74e-18 | 122 |
hsa0412010 | Liver | NAFLD | Ubiquitin mediated proteolysis | 44/1043 | 142/8465 | 2.59e-09 | 1.70e-07 | 1.37e-07 | 44 |
hsa0412011 | Liver | NAFLD | Ubiquitin mediated proteolysis | 44/1043 | 142/8465 | 2.59e-09 | 1.70e-07 | 1.37e-07 | 44 |
hsa0412021 | Liver | Cirrhotic | Ubiquitin mediated proteolysis | 72/2530 | 142/8465 | 1.32e-07 | 1.97e-06 | 1.21e-06 | 72 |
hsa0412031 | Liver | Cirrhotic | Ubiquitin mediated proteolysis | 72/2530 | 142/8465 | 1.32e-07 | 1.97e-06 | 1.21e-06 | 72 |
hsa0412041 | Liver | HCC | Ubiquitin mediated proteolysis | 110/4020 | 142/8465 | 1.67e-13 | 3.74e-12 | 2.08e-12 | 110 |
hsa0412051 | Liver | HCC | Ubiquitin mediated proteolysis | 110/4020 | 142/8465 | 1.67e-13 | 3.74e-12 | 2.08e-12 | 110 |
hsa0412020 | Oral cavity | OSCC | Ubiquitin mediated proteolysis | 105/3704 | 142/8465 | 1.83e-13 | 4.37e-12 | 2.23e-12 | 105 |
hsa04120110 | Oral cavity | OSCC | Ubiquitin mediated proteolysis | 105/3704 | 142/8465 | 1.83e-13 | 4.37e-12 | 2.23e-12 | 105 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UBA2 | SNV | Missense_Mutation | novel | c.1351N>T | p.Thr451Ser | p.T451S | Q9UBT2 | protein_coding | tolerated(0.12) | benign(0.168) | TCGA-SJ-A6ZJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UBA2 | insertion | Frame_Shift_Ins | novel | c.1351_1352insAT | p.Thr451AsnfsTer5 | p.T451Nfs*5 | Q9UBT2 | protein_coding | TCGA-B5-A11I-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | paclitaxel | PD | ||
UBA2 | insertion | Frame_Shift_Ins | novel | c.1352_1353insCAGG | p.Val452ArgfsTer8 | p.V452Rfs*8 | Q9UBT2 | protein_coding | TCGA-B5-A11I-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | paclitaxel | PD | ||
UBA2 | insertion | Frame_Shift_Ins | novel | c.1353_1354insCCAG | p.Val452ProfsTer8 | p.V452Pfs*8 | Q9UBT2 | protein_coding | TCGA-D1-A102-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
UBA2 | SNV | Missense_Mutation | c.265A>G | p.Ile89Val | p.I89V | Q9UBT2 | protein_coding | tolerated(0.06) | possibly_damaging(0.823) | TCGA-05-4418-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
UBA2 | SNV | Missense_Mutation | rs781352231 | c.361G>A | p.Ala121Thr | p.A121T | Q9UBT2 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-49-AAR3-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
UBA2 | SNV | Missense_Mutation | c.1385N>C | p.Leu462Pro | p.L462P | Q9UBT2 | protein_coding | tolerated(0.14) | benign(0.162) | TCGA-62-A46O-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
UBA2 | SNV | Missense_Mutation | c.1596N>G | p.Ile532Met | p.I532M | Q9UBT2 | protein_coding | deleterious(0) | benign(0.386) | TCGA-91-6830-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
UBA2 | SNV | Missense_Mutation | c.748N>T | p.Asp250Tyr | p.D250Y | Q9UBT2 | protein_coding | deleterious(0) | benign(0.215) | TCGA-91-6840-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
UBA2 | SNV | Missense_Mutation | novel | c.1168N>T | p.Thr390Ser | p.T390S | Q9UBT2 | protein_coding | tolerated(0.06) | probably_damaging(0.996) | TCGA-22-4604-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Targeted Molecular therapy | iressa | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
10054 | UBA2 | DRUGGABLE GENOME, ENZYME | LOBARIC ACID | LOBARIC ACID | ||
10054 | UBA2 | DRUGGABLE GENOME, ENZYME | BETULINIC ACID | BETULINIC ACID | ||
10054 | UBA2 | DRUGGABLE GENOME, ENZYME | PEVONEDISTAT | PEVONEDISTAT | ||
10054 | UBA2 | DRUGGABLE GENOME, ENZYME | ASTERRIC ACID | ASTERRIC ACID | ||
10054 | UBA2 | DRUGGABLE GENOME, ENZYME | LIPOIC ACID, ALPHA | LIPOIC ACID, ALPHA | ||
10054 | UBA2 | DRUGGABLE GENOME, ENZYME | 4-PHENYLAMINO-[1,2]NAPHTHOQUINONE | CHEMBL299853 | ||
10054 | UBA2 | DRUGGABLE GENOME, ENZYME | BENSERAZIDE HYDROCHLORIDE | BENSERAZIDE HYDROCHLORIDE | ||
10054 | UBA2 | DRUGGABLE GENOME, ENZYME | GINGKOLIC ACID | GINGKOLIC ACID | 23920437 |
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