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Gene: TUSC3 |
Gene summary for TUSC3 |
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Gene information | Species | Human | Gene symbol | TUSC3 | Gene ID | 7991 |
Gene name | tumor suppressor candidate 3 | |
Gene Alias | D8S1992 | |
Cytomap | 8p22 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | Q13454 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7991 | TUSC3 | LZE2T | Human | Esophagus | ESCC | 3.77e-05 | 7.75e-01 | 0.082 |
7991 | TUSC3 | LZE4T | Human | Esophagus | ESCC | 9.92e-17 | 6.66e-01 | 0.0811 |
7991 | TUSC3 | LZE20T | Human | Esophagus | ESCC | 4.22e-06 | 1.52e-01 | 0.0662 |
7991 | TUSC3 | LZE22T | Human | Esophagus | ESCC | 1.11e-08 | 7.03e-01 | 0.068 |
7991 | TUSC3 | P2T-E | Human | Esophagus | ESCC | 2.70e-130 | 2.69e+00 | 0.1177 |
7991 | TUSC3 | P4T-E | Human | Esophagus | ESCC | 7.47e-77 | 2.19e+00 | 0.1323 |
7991 | TUSC3 | P5T-E | Human | Esophagus | ESCC | 2.39e-24 | 5.69e-01 | 0.1327 |
7991 | TUSC3 | P8T-E | Human | Esophagus | ESCC | 6.71e-60 | 1.23e+00 | 0.0889 |
7991 | TUSC3 | P9T-E | Human | Esophagus | ESCC | 2.14e-09 | 5.08e-01 | 0.1131 |
7991 | TUSC3 | P10T-E | Human | Esophagus | ESCC | 6.60e-111 | 2.37e+00 | 0.116 |
7991 | TUSC3 | P11T-E | Human | Esophagus | ESCC | 2.77e-07 | 7.21e-01 | 0.1426 |
7991 | TUSC3 | P12T-E | Human | Esophagus | ESCC | 9.13e-35 | 7.76e-01 | 0.1122 |
7991 | TUSC3 | P16T-E | Human | Esophagus | ESCC | 7.46e-101 | 1.99e+00 | 0.1153 |
7991 | TUSC3 | P17T-E | Human | Esophagus | ESCC | 2.55e-08 | 8.01e-01 | 0.1278 |
7991 | TUSC3 | P19T-E | Human | Esophagus | ESCC | 3.90e-03 | 8.29e-01 | 0.1662 |
7991 | TUSC3 | P20T-E | Human | Esophagus | ESCC | 1.80e-22 | 4.23e-01 | 0.1124 |
7991 | TUSC3 | P21T-E | Human | Esophagus | ESCC | 2.18e-51 | 1.11e+00 | 0.1617 |
7991 | TUSC3 | P22T-E | Human | Esophagus | ESCC | 8.16e-75 | 1.36e+00 | 0.1236 |
7991 | TUSC3 | P23T-E | Human | Esophagus | ESCC | 6.50e-22 | 9.25e-01 | 0.108 |
7991 | TUSC3 | P24T-E | Human | Esophagus | ESCC | 9.15e-56 | 1.39e+00 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000648714 | Esophagus | ESCC | protein N-linked glycosylation | 51/8552 | 65/18723 | 6.41e-08 | 1.13e-06 | 51 |
GO:00091002 | Esophagus | ESCC | glycoprotein metabolic process | 226/8552 | 387/18723 | 2.64e-07 | 3.94e-06 | 226 |
GO:00181969 | Esophagus | ESCC | peptidyl-asparagine modification | 22/8552 | 24/18723 | 2.82e-06 | 3.21e-05 | 22 |
GO:00700854 | Esophagus | ESCC | glycosylation | 144/8552 | 240/18723 | 5.12e-06 | 5.38e-05 | 144 |
GO:00182799 | Esophagus | ESCC | protein N-linked glycosylation via asparagine | 21/8552 | 23/18723 | 5.69e-06 | 5.90e-05 | 21 |
GO:00064865 | Esophagus | ESCC | protein glycosylation | 135/8552 | 226/18723 | 1.36e-05 | 1.24e-04 | 135 |
GO:00434135 | Esophagus | ESCC | macromolecule glycosylation | 135/8552 | 226/18723 | 1.36e-05 | 1.24e-04 | 135 |
GO:00091012 | Esophagus | ESCC | glycoprotein biosynthetic process | 181/8552 | 317/18723 | 2.54e-05 | 2.15e-04 | 181 |
GO:00182795 | Liver | Cirrhotic | protein N-linked glycosylation via asparagine | 16/4634 | 23/18723 | 7.54e-06 | 1.15e-04 | 16 |
GO:00181965 | Liver | Cirrhotic | peptidyl-asparagine modification | 16/4634 | 24/18723 | 1.74e-05 | 2.37e-04 | 16 |
GO:00064873 | Liver | Cirrhotic | protein N-linked glycosylation | 30/4634 | 65/18723 | 1.40e-04 | 1.36e-03 | 30 |
GO:000648711 | Liver | HCC | protein N-linked glycosylation | 48/7958 | 65/18723 | 2.85e-07 | 5.00e-06 | 48 |
GO:001819611 | Liver | HCC | peptidyl-asparagine modification | 21/7958 | 24/18723 | 6.62e-06 | 7.97e-05 | 21 |
GO:001827911 | Liver | HCC | protein N-linked glycosylation via asparagine | 20/7958 | 23/18723 | 1.37e-05 | 1.51e-04 | 20 |
GO:00064862 | Liver | HCC | protein glycosylation | 122/7958 | 226/18723 | 3.11e-04 | 2.21e-03 | 122 |
GO:00434132 | Liver | HCC | macromolecule glycosylation | 122/7958 | 226/18723 | 3.11e-04 | 2.21e-03 | 122 |
GO:00700852 | Liver | HCC | glycosylation | 128/7958 | 240/18723 | 4.35e-04 | 2.92e-03 | 128 |
GO:0009100 | Liver | HCC | glycoprotein metabolic process | 193/7958 | 387/18723 | 1.89e-03 | 9.62e-03 | 193 |
GO:00064875 | Oral cavity | OSCC | protein N-linked glycosylation | 44/7305 | 65/18723 | 2.63e-06 | 3.26e-05 | 44 |
GO:00181968 | Oral cavity | OSCC | peptidyl-asparagine modification | 20/7305 | 24/18723 | 1.10e-05 | 1.14e-04 | 20 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04141211 | Esophagus | ESCC | Protein processing in endoplasmic reticulum | 147/4205 | 174/8465 | 3.29e-22 | 1.10e-19 | 5.64e-20 | 147 |
hsa0051023 | Esophagus | ESCC | N-Glycan biosynthesis | 39/4205 | 53/8465 | 3.26e-04 | 1.15e-03 | 5.89e-04 | 39 |
hsa005136 | Esophagus | ESCC | Various types of N-glycan biosynthesis | 31/4205 | 42/8465 | 1.23e-03 | 3.78e-03 | 1.93e-03 | 31 |
hsa04141310 | Esophagus | ESCC | Protein processing in endoplasmic reticulum | 147/4205 | 174/8465 | 3.29e-22 | 1.10e-19 | 5.64e-20 | 147 |
hsa0051033 | Esophagus | ESCC | N-Glycan biosynthesis | 39/4205 | 53/8465 | 3.26e-04 | 1.15e-03 | 5.89e-04 | 39 |
hsa0051313 | Esophagus | ESCC | Various types of N-glycan biosynthesis | 31/4205 | 42/8465 | 1.23e-03 | 3.78e-03 | 1.93e-03 | 31 |
hsa0414114 | Liver | Cirrhotic | Protein processing in endoplasmic reticulum | 114/2530 | 174/8465 | 1.16e-22 | 9.67e-21 | 5.96e-21 | 114 |
hsa005104 | Liver | Cirrhotic | N-Glycan biosynthesis | 32/2530 | 53/8465 | 3.82e-06 | 4.10e-05 | 2.53e-05 | 32 |
hsa005134 | Liver | Cirrhotic | Various types of N-glycan biosynthesis | 26/2530 | 42/8465 | 1.65e-05 | 1.41e-04 | 8.69e-05 | 26 |
hsa0414115 | Liver | Cirrhotic | Protein processing in endoplasmic reticulum | 114/2530 | 174/8465 | 1.16e-22 | 9.67e-21 | 5.96e-21 | 114 |
hsa0051011 | Liver | Cirrhotic | N-Glycan biosynthesis | 32/2530 | 53/8465 | 3.82e-06 | 4.10e-05 | 2.53e-05 | 32 |
hsa0051311 | Liver | Cirrhotic | Various types of N-glycan biosynthesis | 26/2530 | 42/8465 | 1.65e-05 | 1.41e-04 | 8.69e-05 | 26 |
hsa0414122 | Liver | HCC | Protein processing in endoplasmic reticulum | 146/4020 | 174/8465 | 7.34e-24 | 2.46e-21 | 1.37e-21 | 146 |
hsa0051021 | Liver | HCC | N-Glycan biosynthesis | 40/4020 | 53/8465 | 2.95e-05 | 1.87e-04 | 1.04e-04 | 40 |
hsa0414132 | Liver | HCC | Protein processing in endoplasmic reticulum | 146/4020 | 174/8465 | 7.34e-24 | 2.46e-21 | 1.37e-21 | 146 |
hsa0051031 | Liver | HCC | N-Glycan biosynthesis | 40/4020 | 53/8465 | 2.95e-05 | 1.87e-04 | 1.04e-04 | 40 |
hsa0414130 | Oral cavity | OSCC | Protein processing in endoplasmic reticulum | 143/3704 | 174/8465 | 6.82e-26 | 2.28e-23 | 1.16e-23 | 143 |
hsa005105 | Oral cavity | OSCC | N-Glycan biosynthesis | 39/3704 | 53/8465 | 9.77e-06 | 4.36e-05 | 2.22e-05 | 39 |
hsa005135 | Oral cavity | OSCC | Various types of N-glycan biosynthesis | 29/3704 | 42/8465 | 8.03e-04 | 2.32e-03 | 1.18e-03 | 29 |
hsa04141113 | Oral cavity | OSCC | Protein processing in endoplasmic reticulum | 143/3704 | 174/8465 | 6.82e-26 | 2.28e-23 | 1.16e-23 | 143 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TUSC3 | SNV | Missense_Mutation | novel | c.929N>G | p.Lys310Arg | p.K310R | Q13454 | protein_coding | tolerated(0.17) | possibly_damaging(0.534) | TCGA-WX-AA44-01 | Liver | liver hepatocellular carcinoma | Female | <65 | I/II | Targeted Molecular therapy | sorafenib | PR |
TUSC3 | SNV | Missense_Mutation | c.221N>T | p.Arg74Leu | p.R74L | Q13454 | protein_coding | deleterious(0.01) | possibly_damaging(0.866) | TCGA-05-4397-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TUSC3 | SNV | Missense_Mutation | rs545107135 | c.85C>T | p.Leu29Phe | p.L29F | Q13454 | protein_coding | tolerated(0.13) | possibly_damaging(0.86) | TCGA-49-4514-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TUSC3 | SNV | Missense_Mutation | c.509G>C | p.Arg170Thr | p.R170T | Q13454 | protein_coding | tolerated(0.13) | possibly_damaging(0.836) | TCGA-67-3771-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TUSC3 | SNV | Missense_Mutation | c.337N>T | p.Ala113Ser | p.A113S | Q13454 | protein_coding | deleterious(0.02) | probably_damaging(0.912) | TCGA-67-6215-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
TUSC3 | SNV | Missense_Mutation | novel | c.565N>A | p.His189Asn | p.H189N | Q13454 | protein_coding | tolerated(0.39) | benign(0.003) | TCGA-86-7701-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | etoposide | PD |
TUSC3 | SNV | Missense_Mutation | c.188N>T | p.Arg63Leu | p.R63L | Q13454 | protein_coding | deleterious(0) | possibly_damaging(0.876) | TCGA-91-A4BC-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TUSC3 | SNV | Missense_Mutation | novel | c.808C>G | p.His270Asp | p.H270D | Q13454 | protein_coding | deleterious(0) | probably_damaging(0.93) | TCGA-NC-A5HK-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TUSC3 | SNV | Missense_Mutation | rs367660078 | c.868N>A | p.Ala290Thr | p.A290T | Q13454 | protein_coding | tolerated(0.06) | benign(0.148) | TCGA-CQ-5330-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | unknown | SD |
TUSC3 | SNV | Missense_Mutation | novel | c.515N>A | p.Gly172Glu | p.G172E | Q13454 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CQ-6220-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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