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Gene: TRIP10 |
Gene summary for TRIP10 |
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Gene information | Species | Human | Gene symbol | TRIP10 | Gene ID | 9322 |
Gene name | thyroid hormone receptor interactor 10 | |
Gene Alias | CIP4 | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q15642 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9322 | TRIP10 | LZE4T | Human | Esophagus | ESCC | 3.46e-06 | -7.02e-02 | 0.0811 |
9322 | TRIP10 | LZE8T | Human | Esophagus | ESCC | 3.55e-03 | 4.39e-02 | 0.067 |
9322 | TRIP10 | LZE22D1 | Human | Esophagus | HGIN | 1.26e-05 | 1.31e-01 | 0.0595 |
9322 | TRIP10 | LZE24T | Human | Esophagus | ESCC | 3.48e-04 | 3.61e-01 | 0.0596 |
9322 | TRIP10 | LZE21T | Human | Esophagus | ESCC | 8.70e-07 | 8.11e-02 | 0.0655 |
9322 | TRIP10 | P1T-E | Human | Esophagus | ESCC | 2.85e-05 | 9.60e-01 | 0.0875 |
9322 | TRIP10 | P2T-E | Human | Esophagus | ESCC | 4.04e-14 | -6.35e-02 | 0.1177 |
9322 | TRIP10 | P4T-E | Human | Esophagus | ESCC | 1.61e-15 | 1.64e-02 | 0.1323 |
9322 | TRIP10 | P5T-E | Human | Esophagus | ESCC | 3.14e-18 | 2.77e-01 | 0.1327 |
9322 | TRIP10 | P8T-E | Human | Esophagus | ESCC | 1.85e-48 | 1.12e+00 | 0.0889 |
9322 | TRIP10 | P9T-E | Human | Esophagus | ESCC | 1.77e-07 | 5.76e-02 | 0.1131 |
9322 | TRIP10 | P10T-E | Human | Esophagus | ESCC | 7.58e-08 | 1.21e-01 | 0.116 |
9322 | TRIP10 | P11T-E | Human | Esophagus | ESCC | 2.45e-02 | 9.98e-02 | 0.1426 |
9322 | TRIP10 | P12T-E | Human | Esophagus | ESCC | 4.05e-17 | 1.21e-01 | 0.1122 |
9322 | TRIP10 | P15T-E | Human | Esophagus | ESCC | 2.16e-09 | 1.47e-01 | 0.1149 |
9322 | TRIP10 | P16T-E | Human | Esophagus | ESCC | 2.36e-14 | -1.02e-01 | 0.1153 |
9322 | TRIP10 | P17T-E | Human | Esophagus | ESCC | 2.46e-10 | 1.66e-01 | 0.1278 |
9322 | TRIP10 | P20T-E | Human | Esophagus | ESCC | 4.31e-11 | 2.22e-02 | 0.1124 |
9322 | TRIP10 | P21T-E | Human | Esophagus | ESCC | 4.53e-13 | 1.91e-01 | 0.1617 |
9322 | TRIP10 | P22T-E | Human | Esophagus | ESCC | 1.66e-08 | -1.82e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa049109 | Esophagus | ESCC | Insulin signaling pathway | 89/4205 | 137/8465 | 1.97e-04 | 7.32e-04 | 3.75e-04 | 89 |
hsa0491014 | Esophagus | ESCC | Insulin signaling pathway | 89/4205 | 137/8465 | 1.97e-04 | 7.32e-04 | 3.75e-04 | 89 |
hsa049108 | Oral cavity | OSCC | Insulin signaling pathway | 83/3704 | 137/8465 | 4.83e-05 | 2.00e-04 | 1.02e-04 | 83 |
hsa0491013 | Oral cavity | OSCC | Insulin signaling pathway | 83/3704 | 137/8465 | 4.83e-05 | 2.00e-04 | 1.02e-04 | 83 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TRIP10 | SNV | Missense_Mutation | novel | c.355N>C | p.Glu119Gln | p.E119Q | Q15642 | protein_coding | deleterious(0.01) | probably_damaging(0.924) | TCGA-BA-6871-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
TRIP10 | SNV | Missense_Mutation | novel | c.26N>T | p.Asp9Val | p.D9V | Q15642 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-CR-6481-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | paclitaxel | SD |
TRIP10 | SNV | Missense_Mutation | novel | c.1304C>T | p.Pro435Leu | p.P435L | Q15642 | protein_coding | deleterious(0.01) | probably_damaging(0.991) | TCGA-CR-7383-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | paclitaxel | PR |
TRIP10 | SNV | Missense_Mutation | novel | c.1199N>A | p.Arg400Gln | p.R400Q | Q15642 | protein_coding | deleterious(0) | probably_damaging(0.945) | TCGA-CV-7248-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TRIP10 | SNV | Missense_Mutation | rs764626879 | c.778N>A | p.Asp260Asn | p.D260N | Q15642 | protein_coding | tolerated(0.24) | probably_damaging(0.952) | TCGA-CV-A45Q-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TRIP10 | insertion | Frame_Shift_Ins | novel | c.361_362insG | p.Arg122AlafsTer11 | p.R122Afs*11 | Q15642 | protein_coding | TCGA-M7-A720-01 | Prostate | prostate adenocarcinoma | Male | <65 | 6 | Unknown | Unknown | SD | ||
TRIP10 | SNV | Missense_Mutation | rs767634125 | c.1397N>T | p.Ala466Val | p.A466V | Q15642 | protein_coding | tolerated(0.34) | benign(0.041) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TRIP10 | SNV | Missense_Mutation | c.434G>A | p.Cys145Tyr | p.C145Y | Q15642 | protein_coding | deleterious(0.02) | benign(0.279) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
TRIP10 | SNV | Missense_Mutation | rs759899109 | c.490N>A | p.Ala164Thr | p.A164T | Q15642 | protein_coding | tolerated(0.09) | benign(0.151) | TCGA-CG-5723-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TRIP10 | SNV | Missense_Mutation | c.213N>T | p.Gln71His | p.Q71H | Q15642 | protein_coding | tolerated(0.21) | possibly_damaging(0.746) | TCGA-CG-5726-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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