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Gene: TNRC6B |
Gene summary for TNRC6B |
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Gene information | Species | Human | Gene symbol | TNRC6B | Gene ID | 23112 |
Gene name | trinucleotide repeat containing adaptor 6B | |
Gene Alias | GDSBA | |
Cytomap | 22q13.1 | |
Gene Type | protein-coding | GO ID | GO:0000288 | UniProtAcc | A0A024R1N5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23112 | TNRC6B | CA_HPV_1 | Human | Cervix | CC | 3.26e-03 | -5.85e-03 | 0.0264 |
23112 | TNRC6B | CA_HPV_3 | Human | Cervix | CC | 2.78e-04 | 6.75e-02 | 0.0414 |
23112 | TNRC6B | CCI_2 | Human | Cervix | CC | 8.12e-12 | 1.04e+00 | 0.5249 |
23112 | TNRC6B | CCI_3 | Human | Cervix | CC | 4.62e-12 | 1.05e+00 | 0.516 |
23112 | TNRC6B | CCII_1 | Human | Cervix | CC | 1.52e-02 | -3.79e-01 | 0.3249 |
23112 | TNRC6B | Tumor | Human | Cervix | CC | 1.80e-02 | -2.77e-01 | 0.1241 |
23112 | TNRC6B | T3 | Human | Cervix | CC | 5.99e-06 | -2.68e-01 | 0.1389 |
23112 | TNRC6B | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.34e-19 | -4.89e-01 | 0.0155 |
23112 | TNRC6B | HTA11_347_2000001011 | Human | Colorectum | AD | 2.54e-12 | 6.08e-01 | -0.1954 |
23112 | TNRC6B | HTA11_8622_2000001021 | Human | Colorectum | SER | 4.89e-04 | -3.80e-01 | 0.0528 |
23112 | TNRC6B | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.23e-04 | -4.45e-01 | 0.0588 |
23112 | TNRC6B | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.22e-05 | -3.19e-01 | 0.294 |
23112 | TNRC6B | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.11e-02 | 6.74e-01 | 0.3487 |
23112 | TNRC6B | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.07e-18 | -5.32e-01 | 0.3005 |
23112 | TNRC6B | F007 | Human | Colorectum | FAP | 2.69e-02 | -1.48e-01 | 0.1176 |
23112 | TNRC6B | A001-C-207 | Human | Colorectum | FAP | 1.09e-02 | -1.64e-01 | 0.1278 |
23112 | TNRC6B | A015-C-203 | Human | Colorectum | FAP | 8.03e-42 | -5.32e-01 | -0.1294 |
23112 | TNRC6B | A015-C-204 | Human | Colorectum | FAP | 1.28e-05 | -3.10e-01 | -0.0228 |
23112 | TNRC6B | A014-C-040 | Human | Colorectum | FAP | 1.81e-05 | -5.12e-01 | -0.1184 |
23112 | TNRC6B | A002-C-201 | Human | Colorectum | FAP | 6.04e-13 | -3.17e-01 | 0.0324 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000989610 | Cervix | CC | positive regulation of catabolic process | 109/2311 | 492/18723 | 5.26e-10 | 6.99e-08 | 109 |
GO:003133110 | Cervix | CC | positive regulation of cellular catabolic process | 91/2311 | 427/18723 | 9.64e-08 | 5.25e-06 | 91 |
GO:00064029 | Cervix | CC | mRNA catabolic process | 56/2311 | 232/18723 | 4.81e-07 | 1.83e-05 | 56 |
GO:19001517 | Cervix | CC | regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | 11/2311 | 18/18723 | 1.37e-06 | 4.55e-05 | 11 |
GO:19033119 | Cervix | CC | regulation of mRNA metabolic process | 64/2311 | 288/18723 | 1.71e-06 | 5.64e-05 | 64 |
GO:00064019 | Cervix | CC | RNA catabolic process | 62/2311 | 278/18723 | 2.18e-06 | 6.56e-05 | 62 |
GO:00002896 | Cervix | CC | nuclear-transcribed mRNA poly(A) tail shortening | 13/2311 | 29/18723 | 1.48e-05 | 2.93e-04 | 13 |
GO:00602119 | Cervix | CC | regulation of nuclear-transcribed mRNA poly(A) tail shortening | 9/2311 | 15/18723 | 1.63e-05 | 3.17e-04 | 9 |
GO:19001536 | Cervix | CC | positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | 9/2311 | 15/18723 | 1.63e-05 | 3.17e-04 | 9 |
GO:000641710 | Cervix | CC | regulation of translation | 89/2311 | 468/18723 | 1.86e-05 | 3.46e-04 | 89 |
GO:00009567 | Cervix | CC | nuclear-transcribed mRNA catabolic process | 30/2311 | 112/18723 | 2.60e-05 | 4.37e-04 | 30 |
GO:00602139 | Cervix | CC | positive regulation of nuclear-transcribed mRNA poly(A) tail shortening | 8/2311 | 13/18723 | 3.85e-05 | 6.05e-04 | 8 |
GO:00002886 | Cervix | CC | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | 18/2311 | 56/18723 | 8.42e-05 | 1.13e-03 | 18 |
GO:00610139 | Cervix | CC | regulation of mRNA catabolic process | 38/2311 | 166/18723 | 1.07e-04 | 1.36e-03 | 38 |
GO:19033136 | Cervix | CC | positive regulation of mRNA metabolic process | 29/2311 | 118/18723 | 1.86e-04 | 2.18e-03 | 29 |
GO:00467008 | Cervix | CC | heterocycle catabolic process | 80/2311 | 445/18723 | 3.23e-04 | 3.42e-03 | 80 |
GO:00346559 | Cervix | CC | nucleobase-containing compound catabolic process | 74/2311 | 407/18723 | 3.77e-04 | 3.88e-03 | 74 |
GO:00434889 | Cervix | CC | regulation of mRNA stability | 35/2311 | 158/18723 | 3.80e-04 | 3.89e-03 | 35 |
GO:00611576 | Cervix | CC | mRNA destabilization | 22/2311 | 84/18723 | 4.18e-04 | 4.23e-03 | 22 |
GO:00610146 | Cervix | CC | positive regulation of mRNA catabolic process | 22/2311 | 87/18723 | 7.03e-04 | 6.40e-03 | 22 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TNRC6B | SNV | Missense_Mutation | novel | c.1768C>T | p.Arg590Cys | p.R590C | Q9UPQ9 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
TNRC6B | SNV | Missense_Mutation | novel | c.2516C>T | p.Ser839Leu | p.S839L | Q9UPQ9 | protein_coding | deleterious(0.01) | probably_damaging(0.945) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
TNRC6B | insertion | Frame_Shift_Ins | novel | c.4052_4053insACCCAAC | p.Ala1354ThrfsTer46 | p.A1354Tfs*46 | Q9UPQ9 | protein_coding | TCGA-AY-A71X-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
TNRC6B | insertion | Frame_Shift_Ins | novel | c.4021_4022insT | p.Gly1342TrpfsTer56 | p.G1342Wfs*56 | Q9UPQ9 | protein_coding | TCGA-DM-A1HB-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | ||
TNRC6B | SNV | Missense_Mutation | rs377560089 | c.452N>T | p.Ala151Val | p.A151V | Q9UPQ9 | protein_coding | tolerated(0.15) | probably_damaging(0.959) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TNRC6B | SNV | Missense_Mutation | novel | c.2378N>T | p.Ser793Leu | p.S793L | Q9UPQ9 | protein_coding | tolerated(0.09) | probably_damaging(0.942) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TNRC6B | SNV | Missense_Mutation | novel | c.2491N>T | p.Pro831Ser | p.P831S | Q9UPQ9 | protein_coding | tolerated(0.49) | benign(0.073) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TNRC6B | SNV | Missense_Mutation | novel | c.1309G>A | p.Val437Ile | p.V437I | Q9UPQ9 | protein_coding | tolerated(0.4) | benign(0.036) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TNRC6B | SNV | Missense_Mutation | rs750465776 | c.2594C>T | p.Ala865Val | p.A865V | Q9UPQ9 | protein_coding | tolerated(0.52) | benign(0) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TNRC6B | SNV | Missense_Mutation | c.3299N>A | p.Arg1100Gln | p.R1100Q | Q9UPQ9 | protein_coding | deleterious(0.01) | probably_damaging(0.974) | TCGA-A5-A0G3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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