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Gene: TMEM132D |
Gene summary for TMEM132D |
Gene summary. |
Gene information | Species | Human | Gene symbol | TMEM132D | Gene ID | 121256 |
Gene name | transmembrane protein 132D | |
Gene Alias | MOLT | |
Cytomap | 12q24.33 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q14C87 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
121256 | TMEM132D | RNA-P23T2-P23T2-4 | Human | Lung | MIAC | 4.84e-05 | 1.34e+00 | -0.0272 |
121256 | TMEM132D | RNA-P24T2-P24T2-2 | Human | Lung | IAC | 4.72e-06 | 1.42e+00 | 0.0057 |
121256 | TMEM132D | RNA-P5T2-P5T2-1 | Human | Lung | MIAC | 2.56e-04 | 1.44e+00 | -0.0135 |
121256 | TMEM132D | RNA-P6T1-P6T1-1 | Human | Lung | MIAC | 6.72e-03 | 9.50e-01 | -0.0238 |
121256 | TMEM132D | RNA-P6T1-P6T1-4 | Human | Lung | MIAC | 1.36e-02 | 8.16e-01 | -0.0263 |
121256 | TMEM132D | RNA-P7T1-P7T1-1 | Human | Lung | AIS | 1.69e-05 | 7.75e-01 | -0.0961 |
121256 | TMEM132D | RNA-P7T1-P7T1-2 | Human | Lung | AIS | 5.59e-06 | 7.83e-01 | -0.0876 |
121256 | TMEM132D | RNA-P7T1-P7T1-3 | Human | Lung | AIS | 2.32e-05 | 7.21e-01 | -0.0822 |
121256 | TMEM132D | RNA-P7T1-P7T1-4 | Human | Lung | AIS | 1.09e-06 | 7.42e-01 | -0.0809 |
121256 | TMEM132D | HTA12-15-2 | Human | Pancreas | PDAC | 1.28e-15 | 1.01e+00 | 0.2315 |
121256 | TMEM132D | HTA12-16-2 | Human | Pancreas | PDAC | 1.71e-02 | 7.57e-01 | 0.0535 |
121256 | TMEM132D | HTA12-23-1 | Human | Pancreas | PDAC | 7.33e-25 | 1.57e+00 | 0.3405 |
121256 | TMEM132D | HTA12-25-1 | Human | Pancreas | PDAC | 9.43e-22 | 1.40e+00 | 0.313 |
121256 | TMEM132D | HTA12-26-1 | Human | Pancreas | PDAC | 2.17e-46 | 1.74e+00 | 0.3728 |
121256 | TMEM132D | HTA12-29-1 | Human | Pancreas | PDAC | 5.10e-104 | 1.69e+00 | 0.3722 |
121256 | TMEM132D | HTA12-30-1 | Human | Pancreas | PDAC | 6.56e-10 | 1.55e+00 | 0.3671 |
121256 | TMEM132D | HTA12-32-1 | Human | Pancreas | PDAC | 1.44e-13 | 1.70e+00 | 0.3624 |
121256 | TMEM132D | HTA12-9-1 | Human | Pancreas | PDAC | 3.82e-02 | 2.81e-01 | 0.1532 |
121256 | TMEM132D | HTA12-9-2 | Human | Pancreas | PDAC | 1.65e-02 | 2.37e-01 | 0.0835 |
121256 | TMEM132D | HTA12-9-3 | Human | Pancreas | PDAC | 1.07e-02 | 5.51e-01 | 0.2045 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Lung | AAH: Atypical adenomatous hyperplasia | |
AIS: Adenocarcinoma in situ | ||
IAC: Invasive lung adenocarcinoma | ||
MIA: Minimally invasive adenocarcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM132D | SNV | Missense_Mutation | c.2743N>A | p.Asp915Asn | p.D915N | Q14C87 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
TMEM132D | SNV | Missense_Mutation | novel | c.2534N>T | p.Ser845Phe | p.S845F | Q14C87 | protein_coding | deleterious(0.02) | benign(0.035) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
TMEM132D | SNV | Missense_Mutation | rs765263700 | c.271N>T | p.Pro91Ser | p.P91S | Q14C87 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD |
TMEM132D | SNV | Missense_Mutation | c.1213N>C | p.Tyr405His | p.Y405H | Q14C87 | protein_coding | deleterious(0.03) | probably_damaging(0.997) | TCGA-AA-A01T-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | CR | |
TMEM132D | SNV | Missense_Mutation | rs750913130 | c.3157N>A | p.Val1053Ile | p.V1053I | Q14C87 | protein_coding | tolerated(1) | benign(0) | TCGA-AY-6196-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
TMEM132D | SNV | Missense_Mutation | c.1792C>A | p.Leu598Met | p.L598M | Q14C87 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AY-6386-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fu | SD | |
TMEM132D | SNV | Missense_Mutation | c.324G>T | p.Gln108His | p.Q108H | Q14C87 | protein_coding | tolerated(0.25) | possibly_damaging(0.655) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TMEM132D | SNV | Missense_Mutation | c.2851N>A | p.Pro951Thr | p.P951T | Q14C87 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TMEM132D | SNV | Missense_Mutation | novel | c.2534N>A | p.Ser845Tyr | p.S845Y | Q14C87 | protein_coding | deleterious(0) | possibly_damaging(0.509) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TMEM132D | SNV | Missense_Mutation | c.1421N>T | p.Ser474Leu | p.S474L | Q14C87 | protein_coding | deleterious(0) | possibly_damaging(0.886) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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