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Gene: TMCO4 |
Gene summary for TMCO4 |
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Gene information | Species | Human | Gene symbol | TMCO4 | Gene ID | 255104 |
Gene name | transmembrane and coiled-coil domains 4 | |
Gene Alias | TMCO4 | |
Cytomap | 1p36.13 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q5TGY1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
255104 | TMCO4 | HTA11_347_2000001011 | Human | Colorectum | AD | 8.91e-12 | 5.29e-01 | -0.1954 |
255104 | TMCO4 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.31e-08 | 5.37e-01 | -0.1464 |
255104 | TMCO4 | HTA11_866_2000001011 | Human | Colorectum | AD | 4.67e-06 | 4.81e-01 | -0.1001 |
255104 | TMCO4 | HTA11_1391_2000001011 | Human | Colorectum | AD | 6.90e-04 | 4.57e-01 | -0.059 |
255104 | TMCO4 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.13e-03 | 5.43e-01 | -0.0842 |
255104 | TMCO4 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.24e-02 | 3.01e-01 | 0.0674 |
255104 | TMCO4 | HTA11_6818_2000001011 | Human | Colorectum | AD | 2.54e-04 | 6.87e-01 | 0.0112 |
255104 | TMCO4 | A015-C-203 | Human | Colorectum | FAP | 9.18e-09 | -1.06e-01 | -0.1294 |
255104 | TMCO4 | A001-C-108 | Human | Colorectum | FAP | 6.43e-04 | -4.30e-02 | -0.0272 |
255104 | TMCO4 | A002-C-021 | Human | Colorectum | FAP | 1.11e-05 | 2.59e-01 | 0.1171 |
255104 | TMCO4 | A002-C-205 | Human | Colorectum | FAP | 1.81e-06 | -2.75e-02 | -0.1236 |
255104 | TMCO4 | A015-C-006 | Human | Colorectum | FAP | 5.04e-04 | -1.74e-01 | -0.0994 |
255104 | TMCO4 | A002-C-114 | Human | Colorectum | FAP | 1.53e-05 | -1.98e-01 | -0.1561 |
255104 | TMCO4 | A015-C-104 | Human | Colorectum | FAP | 3.43e-08 | -9.63e-02 | -0.1899 |
255104 | TMCO4 | A002-C-016 | Human | Colorectum | FAP | 8.51e-08 | -1.60e-01 | 0.0521 |
255104 | TMCO4 | A015-C-002 | Human | Colorectum | FAP | 3.76e-03 | -2.48e-01 | -0.0763 |
255104 | TMCO4 | A002-C-116 | Human | Colorectum | FAP | 5.01e-12 | -8.42e-02 | -0.0452 |
255104 | TMCO4 | A014-C-008 | Human | Colorectum | FAP | 1.10e-02 | -1.45e-01 | -0.191 |
255104 | TMCO4 | A018-E-020 | Human | Colorectum | FAP | 1.56e-05 | -1.02e-01 | -0.2034 |
255104 | TMCO4 | F034 | Human | Colorectum | FAP | 7.49e-07 | -1.12e-01 | -0.0665 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMCO4 | SNV | Missense_Mutation | novel | c.314N>T | p.Lys105Met | p.K105M | Q5TGY1 | protein_coding | deleterious(0.03) | possibly_damaging(0.754) | TCGA-85-6798-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | etoposide | PD |
TMCO4 | SNV | Missense_Mutation | rs113501810 | c.1861N>A | p.Asp621Asn | p.D621N | Q5TGY1 | protein_coding | tolerated_low_confidence(0.09) | benign(0) | TCGA-85-8666-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TMCO4 | SNV | Missense_Mutation | rs146596460 | c.605N>T | p.Thr202Met | p.T202M | Q5TGY1 | protein_coding | deleterious(0.01) | probably_damaging(0.993) | TCGA-LA-A7SW-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | cisplatin | PD |
TMCO4 | SNV | Missense_Mutation | novel | c.382N>T | p.Gly128Trp | p.G128W | Q5TGY1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CN-6010-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
TMCO4 | SNV | Missense_Mutation | c.37C>G | p.Gln13Glu | p.Q13E | Q5TGY1 | protein_coding | tolerated_low_confidence(0.33) | benign(0) | TCGA-CV-6936-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
TMCO4 | SNV | Missense_Mutation | novel | c.1577N>T | p.Trp526Leu | p.W526L | Q5TGY1 | protein_coding | tolerated(0.88) | benign(0.06) | TCGA-CV-7263-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
TMCO4 | SNV | Missense_Mutation | rs367840733 | c.1421N>T | p.Ser474Leu | p.S474L | Q5TGY1 | protein_coding | deleterious(0.01) | benign(0.234) | TCGA-J9-A52C-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD |
TMCO4 | SNV | Missense_Mutation | rs146596460 | c.605N>T | p.Thr202Met | p.T202M | Q5TGY1 | protein_coding | deleterious(0.01) | probably_damaging(0.993) | TCGA-KK-A6E8-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | SD |
TMCO4 | deletion | Frame_Shift_Del | novel | c.1788_1791delNNNN | p.Pro597LeufsTer83 | p.P597Lfs*83 | Q5TGY1 | protein_coding | TCGA-KK-A59V-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD | ||
TMCO4 | SNV | Missense_Mutation | c.1834N>G | p.Met612Val | p.M612V | Q5TGY1 | protein_coding | tolerated_low_confidence(1) | benign(0) | TCGA-BR-4201-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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