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Gene: TMC6 |
Gene summary for TMC6 |
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Gene information | Species | Human | Gene symbol | TMC6 | Gene ID | 11322 |
Gene name | transmembrane channel like 6 | |
Gene Alias | EV1 | |
Cytomap | 17q25.3 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | A0A024R8V2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11322 | TMC6 | LZE4T | Human | Esophagus | ESCC | 2.93e-11 | 1.90e-01 | 0.0811 |
11322 | TMC6 | LZE5T | Human | Esophagus | ESCC | 1.04e-05 | 3.20e-01 | 0.0514 |
11322 | TMC6 | LZE7T | Human | Esophagus | ESCC | 3.55e-13 | 4.78e-01 | 0.0667 |
11322 | TMC6 | LZE8T | Human | Esophagus | ESCC | 5.57e-10 | 3.14e-01 | 0.067 |
11322 | TMC6 | LZE20T | Human | Esophagus | ESCC | 4.22e-04 | 2.08e-01 | 0.0662 |
11322 | TMC6 | LZE21D1 | Human | Esophagus | HGIN | 6.35e-03 | 2.88e-01 | 0.0632 |
11322 | TMC6 | LZE22D1 | Human | Esophagus | HGIN | 1.92e-04 | 1.95e-01 | 0.0595 |
11322 | TMC6 | LZE24T | Human | Esophagus | ESCC | 3.80e-20 | 2.81e-01 | 0.0596 |
11322 | TMC6 | LZE21T | Human | Esophagus | ESCC | 7.35e-10 | 3.66e-01 | 0.0655 |
11322 | TMC6 | LZE6T | Human | Esophagus | ESCC | 2.44e-06 | 2.83e-01 | 0.0845 |
11322 | TMC6 | P1T-E | Human | Esophagus | ESCC | 2.73e-12 | 4.83e-01 | 0.0875 |
11322 | TMC6 | P2T-E | Human | Esophagus | ESCC | 4.44e-08 | 1.64e-01 | 0.1177 |
11322 | TMC6 | P4T-E | Human | Esophagus | ESCC | 1.40e-16 | 2.24e-01 | 0.1323 |
11322 | TMC6 | P5T-E | Human | Esophagus | ESCC | 4.31e-06 | 1.20e-01 | 0.1327 |
11322 | TMC6 | P8T-E | Human | Esophagus | ESCC | 5.17e-27 | 4.65e-01 | 0.0889 |
11322 | TMC6 | P9T-E | Human | Esophagus | ESCC | 2.87e-20 | 2.23e-01 | 0.1131 |
11322 | TMC6 | P10T-E | Human | Esophagus | ESCC | 4.30e-10 | 1.49e-01 | 0.116 |
11322 | TMC6 | P11T-E | Human | Esophagus | ESCC | 1.23e-16 | 8.87e-01 | 0.1426 |
11322 | TMC6 | P12T-E | Human | Esophagus | ESCC | 1.02e-31 | 5.05e-01 | 0.1122 |
11322 | TMC6 | P15T-E | Human | Esophagus | ESCC | 2.25e-29 | 5.40e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMC6 | SNV | Missense_Mutation | rs752560268 | c.28N>A | p.Asp10Asn | p.D10N | Q7Z403 | protein_coding | tolerated(0.73) | benign(0) | TCGA-96-7545-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
TMC6 | SNV | Missense_Mutation | rs373911642 | c.2314N>T | p.His772Tyr | p.H772Y | Q7Z403 | protein_coding | deleterious(0.01) | possibly_damaging(0.61) | TCGA-O2-A52N-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TMC6 | SNV | Missense_Mutation | rs571643180 | c.1184G>T | p.Arg395Leu | p.R395L | Q7Z403 | protein_coding | tolerated(0.21) | benign(0.115) | TCGA-D6-6823-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TMC6 | SNV | Missense_Mutation | rs201290210 | c.826N>A | p.Ala276Thr | p.A276T | Q7Z403 | protein_coding | tolerated(0.2) | possibly_damaging(0.636) | TCGA-P3-A6T7-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
TMC6 | SNV | Missense_Mutation | novel | c.1857N>G | p.Ile619Met | p.I619M | Q7Z403 | protein_coding | deleterious(0.03) | benign(0.209) | TCGA-T2-A6WX-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
TMC6 | SNV | Missense_Mutation | c.1388C>T | p.Pro463Leu | p.P463L | Q7Z403 | protein_coding | tolerated(0.4) | benign(0) | TCGA-H9-A6BY-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD | |
TMC6 | SNV | Missense_Mutation | novel | c.733N>A | p.Val245Met | p.V245M | Q7Z403 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
TMC6 | SNV | Missense_Mutation | novel | c.974G>C | p.Gly325Ala | p.G325A | Q7Z403 | protein_coding | tolerated(0.13) | benign(0.084) | TCGA-BR-4369-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TMC6 | SNV | Missense_Mutation | c.16N>A | p.Ala6Thr | p.A6T | Q7Z403 | protein_coding | tolerated(0.3) | benign(0.001) | TCGA-CD-A4MG-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
TMC6 | SNV | Missense_Mutation | c.88N>A | p.Val30Met | p.V30M | Q7Z403 | protein_coding | deleterious(0.03) | probably_damaging(0.945) | TCGA-FP-A4BE-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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