Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: THRB

Gene summary for THRB

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

THRB

Gene ID

7068

Gene namethyroid hormone receptor beta
Gene AliasC-ERBA-2
Cytomap3p24.2
Gene Typeprotein-coding
GO ID

GO:0000003

UniProtAcc

F1D8N7


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
7068THRBHTA11_3410_2000001011HumanColorectumAD1.52e-15-5.62e-010.0155
7068THRBHTA11_2951_2000001011HumanColorectumAD9.37e-04-6.80e-010.0216
7068THRBHTA11_347_2000001011HumanColorectumAD6.12e-157.90e-01-0.1954
7068THRBHTA11_411_2000001011HumanColorectumSER3.46e-071.12e+00-0.2602
7068THRBHTA11_83_2000001011HumanColorectumSER3.62e-07-6.33e-01-0.1526
7068THRBHTA11_1391_2000001011HumanColorectumAD1.02e-10-5.36e-01-0.059
7068THRBHTA11_546_2000001011HumanColorectumAD4.81e-03-5.12e-01-0.0842
7068THRBHTA11_866_3004761011HumanColorectumAD5.75e-19-6.41e-010.096
7068THRBHTA11_8622_2000001021HumanColorectumSER2.68e-04-6.55e-010.0528
7068THRBHTA11_10623_2000001011HumanColorectumAD2.26e-02-5.12e-01-0.0177
7068THRBHTA11_6801_2000001011HumanColorectumSER2.83e-03-6.80e-010.0171
7068THRBHTA11_10711_2000001011HumanColorectumAD7.95e-10-6.06e-010.0338
7068THRBHTA11_7696_3000711011HumanColorectumAD3.47e-22-6.55e-010.0674
7068THRBHTA11_6818_2000001021HumanColorectumAD7.70e-04-4.38e-010.0588
7068THRBHTA11_99999970781_79442HumanColorectumMSS9.10e-25-6.42e-010.294
7068THRBHTA11_99999971662_82457HumanColorectumMSS9.00e-12-4.33e-010.3859
7068THRBHTA11_99999973899_84307HumanColorectumMSS2.35e-07-6.47e-010.2585
7068THRBHTA11_99999974143_84620HumanColorectumMSS5.28e-14-5.06e-010.3005
7068THRBF007HumanColorectumFAP2.22e-07-5.15e-010.1176
7068THRBA001-C-207HumanColorectumFAP3.78e-04-3.31e-010.1278
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0070997ColorectumADneuron death114/3918361/187231.13e-063.72e-05114
GO:0030522ColorectumADintracellular receptor signaling pathway87/3918265/187233.69e-061.03e-0487
GO:0009755ColorectumADhormone-mediated signaling pathway64/3918190/187232.78e-055.24e-0464
GO:0051402ColorectumADneuron apoptotic process77/3918246/187238.07e-051.28e-0377
GO:00709971ColorectumSERneuron death84/2897361/187235.76e-051.35e-0384
GO:00097551ColorectumSERhormone-mediated signaling pathway49/2897190/187231.54e-043.00e-0349
GO:00514021ColorectumSERneuron apoptotic process60/2897246/187231.65e-043.13e-0360
GO:00305221ColorectumSERintracellular receptor signaling pathway63/2897265/187232.47e-044.20e-0363
GO:00305222ColorectumMSSintracellular receptor signaling pathway84/3467265/187231.47e-076.79e-0684
GO:00097552ColorectumMSShormone-mediated signaling pathway63/3467190/187239.26e-073.23e-0563
GO:00709972ColorectumMSSneuron death97/3467361/187235.21e-059.31e-0497
GO:00514022ColorectumMSSneuron apoptotic process66/3467246/187237.94e-048.36e-0366
GO:00305223ColorectumFAPintracellular receptor signaling pathway67/2622265/187236.84e-073.28e-0567
GO:00097554ColorectumFAPhormone-mediated signaling pathway51/2622190/187232.23e-068.87e-0551
GO:00709974ColorectumFAPneuron death81/2622361/187238.35e-062.46e-0481
GO:00514024ColorectumFAPneuron apoptotic process55/2622246/187232.42e-043.37e-0355
GO:0060428ColorectumFAPlung epithelium development12/262237/187233.43e-032.48e-0212
GO:0030323ColorectumFAPrespiratory tube development39/2622181/187233.60e-032.58e-0239
GO:0048593ColorectumFAPcamera-type eye morphogenesis28/2622120/187233.98e-032.76e-0228
GO:0030324ColorectumFAPlung development38/2622177/187234.28e-032.93e-0238
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa04919ColorectumADThyroid hormone signaling pathway51/2092121/84651.71e-051.73e-041.10e-0451
hsa049191ColorectumADThyroid hormone signaling pathway51/2092121/84651.71e-051.73e-041.10e-0451
hsa049192ColorectumSERThyroid hormone signaling pathway40/1580121/84651.02e-041.06e-037.67e-0440
hsa049193ColorectumSERThyroid hormone signaling pathway40/1580121/84651.02e-041.06e-037.67e-0440
hsa049194ColorectumMSSThyroid hormone signaling pathway46/1875121/84655.04e-054.97e-043.05e-0446
hsa049195ColorectumMSSThyroid hormone signaling pathway46/1875121/84655.04e-054.97e-043.05e-0446
hsa049198ColorectumFAPThyroid hormone signaling pathway41/1404121/84652.28e-064.28e-052.60e-0541
hsa049199ColorectumFAPThyroid hormone signaling pathway41/1404121/84652.28e-064.28e-052.60e-0541
hsa0491910ColorectumCRCThyroid hormone signaling pathway35/1091121/84652.05e-066.85e-054.64e-0535
hsa0491911ColorectumCRCThyroid hormone signaling pathway35/1091121/84652.05e-066.85e-054.64e-0535
hsa0491912LiverHCCThyroid hormone signaling pathway75/4020121/84658.76e-043.38e-031.88e-0375
hsa0491913LiverHCCThyroid hormone signaling pathway75/4020121/84658.76e-043.38e-031.88e-0375
hsa0491914LungIACThyroid hormone signaling pathway27/1053121/84651.61e-039.49e-036.30e-0327
hsa0491915LungIACThyroid hormone signaling pathway27/1053121/84651.61e-039.49e-036.30e-0327
hsa0491921LungAISThyroid hormone signaling pathway27/961121/84653.92e-043.85e-032.47e-0327
hsa0491931LungAISThyroid hormone signaling pathway27/961121/84653.92e-043.85e-032.47e-0327
hsa0491941LungMIACThyroid hormone signaling pathway16/507121/84652.23e-032.03e-021.47e-0216
hsa0491951LungMIACThyroid hormone signaling pathway16/507121/84652.23e-032.03e-021.47e-0216
hsa0491924ProstateBPHThyroid hormone signaling pathway39/1718121/84651.27e-035.58e-033.45e-0339
hsa04919111ProstateBPHThyroid hormone signaling pathway39/1718121/84651.27e-035.58e-033.45e-0339
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
THRBCD8TEREXColorectumMSSZBTB16,FAM126A,LPGAT1, etc.6.42e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
THRBBMEMColorectumMSSZBTB16,FAM126A,LPGAT1, etc.5.98e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
THRBLCLungAAHCPVL,C1orf54,CPNE3, etc.2.29e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
THRBBNLungAAHCPVL,C1orf54,CPNE3, etc.3.38e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
THRBcDCLungAAHCPVL,C1orf54,CPNE3, etc.7.03e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
THRBpDCLungMIACCHIT1,CALM3,FN1, etc.7.57e-04The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
THRBPLALungMIACCHIT1,CALM3,FN1, etc.1.77e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
THRBcDCLungMIACCHIT1,CALM3,FN1, etc.4.19e-03The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
THRBM2MACLungMIACCHIT1,CALM3,FN1, etc.4.90e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
THRBINMONLungMIACCHIT1,CALM3,FN1, etc.2.23e-03The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
THRBSNVMissense_Mutationnovelc.587N>Tp.Arg196Leup.R196LP10828protein_codingdeleterious(0.04)probably_damaging(0.994)TCGA-EQ-8122-01Stomachstomach adenocarcinomaFemale>=65I/IIChemotherapy5-fluorouracilSD
THRBSNVMissense_Mutationc.1371N>Cp.Glu457Aspp.E457DP10828protein_codingdeleterious(0.02)possibly_damaging(0.825)TCGA-HU-A4GH-01Stomachstomach adenocarcinomaMale>=65I/IIUnknownUnknownSD
THRBSNVMissense_Mutationc.940N>Cp.Ser314Prop.S314PP10828protein_codingdeleterious(0.01)probably_damaging(0.996)TCGA-HU-A4GU-01Stomachstomach adenocarcinomaMale>=65I/IIUnknownUnknownSD
THRBSNVMissense_Mutationnovelc.1229N>Ap.Arg410Glnp.R410QP10828protein_codingdeleterious(0.03)probably_damaging(0.994)TCGA-KB-A93H-01Stomachstomach adenocarcinomaFemale>=65I/IIUnknownUnknownSD
THRBinsertionNonsense_Mutationnovelc.149_150insGGACGCCTAGTp.Asn51AspfsTer3p.N51Dfs*3P10828protein_codingTCGA-FY-A4B0-01Thyroidthyroid carcinomaMale>=65I/IIHormone TherapysynthroidSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
7068THRBDRUGGABLE GENOME, NUCLEAR HORMONE RECEPTORLEVOTHYROXINELEVOTHYROXINE
7068THRBDRUGGABLE GENOME, NUCLEAR HORMONE RECEPTORVK-2809
7068THRBDRUGGABLE GENOME, NUCLEAR HORMONE RECEPTORBENZO[D]ISOTHIAZOL-3-ONECHEMBL297304
7068THRBDRUGGABLE GENOME, NUCLEAR HORMONE RECEPTOR(+)-THALIPORPHINECHEMBL1397308
7068THRBDRUGGABLE GENOME, NUCLEAR HORMONE RECEPTORROSE BENGALROSE BENGAL
7068THRBDRUGGABLE GENOME, NUCLEAR HORMONE RECEPTORGNF-PF-321CHEMBL581044
7068THRBDRUGGABLE GENOME, NUCLEAR HORMONE RECEPTOR3-METHYLCHOLANTHRENE3-METHYLCHOLANTHRENE
7068THRBDRUGGABLE GENOME, NUCLEAR HORMONE RECEPTORPROTOPORPHYRINPROTOPORPHYRIN
7068THRBDRUGGABLE GENOME, NUCLEAR HORMONE RECEPTORERYTHROSINEERYTHROSINE
7068THRBDRUGGABLE GENOME, NUCLEAR HORMONE RECEPTORAMMONIA SOLUTION, STRONGAMMONIA SOLUTION, STRONG22324546
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